Navigation Links
Wheat Germ Extract Inhibits Breast Cancer in Study

CHICAGO, A fermented wheat germ extract inhibits estrogen positive and estrogen negative breast cancer tumors better than the world's best selling cancer drug, Tamoxifen, according to research published this past weekend at the 2007 meeting of the American Society of Clinical Oncology, ASCO.

The compound, Avemar, has been extensively studied in many cell lines, animal tumor models, and several human clinical trials. In the current study, Andras Telekes, MD, Ph.D., head physician at the Hungarian National Institute of Oncology, and colleagues, implanted estrogen receptor-positive (ER+) and estrogen receptor-negative (ER-) breast tumors from humans and mouse cell lines into female mice and monitored tumor growth.

They compared tumor growth in mice treated with Avemar alone, or treated with three of the most widely used and studied breast cancer drugs: Tamoxifen, Aromasin, or Arimidex, alone, and combinations of those drugs with Avemar.

Against the mouse ER+ cell line, MXT, Avemar inhibited growth by 50%, Aromasin by 46.7%, Tamoxifen by 34% and Arimidex by 29.3%. Against the human ER+ cell line, T47T, Avemar inhibited growth by 49%, Tamoxifen 42%, Aromasin 25% and Arimidex 25%. Each agent was enhanced by 5 to 10% when combined with Avemar. Most effective was a combination of Aromasin and Avemar, inhibiting both the mouse and human derived ER+ breast tumors by 60%.

Effects against estrogen receptor-negative (ER-) breast cancer were measured with the human derived, MDA-MB-231 cell line. Estrogen-blocking drugs are not effective against ER- breast cancers, so they were not tested in this tumor model. However, Avemar did inhibit the growth of the ER-negative MDA-MB-231 breast tumors significantly (52%), suggesting to researchers that the mechanism by which the extract works is different from that of the anti- estrogen drugs, and is independent of a breast tumor's estrogen receptor status.

Avemar's effic acy against both ER+ and ER- tumor types suggests the compound's mechanisms of action against breast cancer may be those that inhibited tumor growth in other cancers, including lung, pancreatic, colon, melanoma, leukemia, and other breast cancer lines, among others, against which the compound has also been tested. Chief among these mechanisms is its ability to interfere with the excess use of glucose by cancer cells (the Warburg effect), which interferes with the synthesis of DNA needed for cell proliferation.


'"/>




Related medicine news :

1. Wheat wards off colon cancer
2. Earlier Introduction of Solid Foods in Infants Could Prevent Wheat Allergy
3. Wheaton College Affected By Mumps Outbreak
4. Whole Wheat, Wholesome for Pregnant Women and Their Offspring
5. Risk Of Breast Cancer Lowered In Offspring Of Mothers Who Eat Whole Wheat
6. Newly Cloned Wheat Gene May Boosts Foods Nutrient Contents – Says A Researc
7. Improved Wheats Could Reduce Magnesium Deficiencies: Research
8. Ancient Genes Used to Produce Salt-Tolerant Wheat
9. Extracts of grapefruit heals stomach ulcers
10. Yet Another Use For Green Tea Extract
11. Tomato Extract Found To Reduce The Risk Of Thrombosis
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2016)... ... , ... Despite last week’s media reports hinting at a June rate hike ... March 2017 for an interest rate increase, according to Rajeev Dhawan of the Economic ... Federal Open Market Committee (FOMC) dot charts are of interest to the press for ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... and clinical outcomes, hosted members and suppliers for its inaugural Member Conference at ... on their mission of elevating the operational health of America’s healthcare providers. , ...
(Date:5/26/2016)... ... May 26, 2016 , ... The Woodlands at ... offering a new model of care for living and healing, celebrated its grand opening, ... Life in a Real Home provided by Empowered Staff. , “This is an incredibly ...
(Date:5/26/2016)... ... May 26, 2016 , ... Catalent Pharma Solutions, ... biologics, consumer health and global clinical supply services, today announced two key appointments ... company’s continued investment and strategic growth plans in the Asia Pacific region. , ...
(Date:5/26/2016)... , ... May 26, 2016 , ... Memorial Day Weekend ... Amica Insurance is sharing tips to make sure your family and vehicle ... the National Safety Council, there may be 439 deaths and an additional 50,500 serious ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... AMSTERDAM , May 24, 2016 ... auf den Markt gebracht, die es Ärzten erlaubt, ... überall zu behandeln: MDLinking kombiniert Live Streaming mit ... sicheren Umfeld zu kommunizieren. Mediziner in Europa, Afrika, ... haben sich bereits für die Plattform registriert. ...
(Date:5/24/2016)... 2016  Diana Russell suffers from a form of ... inside out.  This disease has put her in a ... and grandchildren to leave her home.  Because of the ... haul the wheelchair.  So if there is a family ... is left to wait for the bus. ...
(Date:5/24/2016)... has joined VMS BioMarketing as senior vice president of sales, announced Andrea Heslin ... will lead the company,s business development and sales team, exploring new opportunities for VMS ... http://photos.prnewswire.com/prnh/20160523/371089 ... ... ...
Breaking Medicine Technology: