Navigation Links
Weizmann Researchers Developed Control Switch for Protein Activity

Our bodies could not maintain their existence without thousands of proteins performing myriad vital tasks within cells. Since malfunctioning proteins can cause disease , the study of protein structure and function can lead to the development of drugs and treatments for numerous disorders. Despite enormous research efforts led by scientists worldwide, the cellular function of numerous proteins is still unknown.

To reveal this function, scientists perform various genetic manipulations to increase or, conversely, decrease the production of a certain protein, but existing manipulations of this sort are complicated and do not fully meet the researchers needs.

Prof. Mordechai Moti Liscovitch and graduate student Oran Erster of the Weizmann Institutes Biological Regulation Department, together with Dr. Miri Eisenstein of Chemical Research Support, have recently developed a unique switch that can control the activity of any protein, raising it several-fold or stopping it almost completely. The method provides researchers with a simple and effective tool for exploring the function of unknown proteins, and in the future the new technique may find many additional uses.

The switch has a genetic component and a chemical component: Using genetic engineering, the scientists insert a short segment of amino acids into the amino acid sequence making up the protein. This segment is capable of binding strongly and selectively to a particular chemical drug, which affects the activity level of the engineered protein by increasing or reducing it. When the drug is no longer applied, or when it is removed from the system, the protein returns to its natural activity level.

As reported recently in the journal Nature Methods, the first stage of the method consists of preparing a set of genetically engineered proteins (called a library in scientific language) with the amino acid segment inserted in different places. In the second stage, the engi
'"/>




Page: 1 2 3

Related medicine news :

1. Weizmann Institute of Science says Immune Cells Could Help Maintain Brain Function
2. Researchers urge caution in using ear tube surgery
3. Researchers Scale to assess the Severity of Epilepsy in Kids
4. Researchers trick Alzheimers Enzyme
5. Researchers find new HIV hiding place
6. New Hair in 15 Days Could Now Be A Possibility Say Researchers
7. Researchers developed world’s smallest toothbrus
8. Researchers discover receptor cells that can cause epilepsy
9. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
10. Researchers reversed the process of memory loss
11. Researchers Identify Key Gene That May Help Brain Treatment
Post Your Comments:
(Date:7/31/2015)... ... July 31, 2015 , ... Girl Scouts of Historic Georgia and Peach State ... Girl Scout "Be a Friend First" program. Representatives from Peach State Health Plan presented ... State Health Plan and our parent company, Centene Corporation, are dedicated to raising anti-bullying ...
(Date:7/31/2015)... Seattle, WA (PRWEB) , ... July 31, 2015 , ... ... rapidly transforming the way we treat aging diseases. , BioViva announces it has ... to treat patients with Alzheimer’s Disease (AD) and find a cure. MaxLife will grant ...
(Date:7/31/2015)... ... , ... The Heart Fit Clinic has increased a patient's fitness level 60 ... 150 beats versus 100 beats, this is a big deal," says Diamond Fernandes, director ... to patients with heart disease," he adds. People with angina are able to do ...
(Date:7/31/2015)... York, NY (PRWEB) , ... July 31, 2015 , ... ... kidney disease, according to a study published today in Nature Communications and led by ... conducted in mice, suggests that variations in the gene RTN1 led to greater production ...
(Date:7/31/2015)... ... , ... Indosoft, Inc., is pleased to announce a major update to its ... contact center ACD system for Asterisk-based call centers . The new features make ... to the agent only when wanted, and allows for validation of data as the ...
Breaking Medicine News(10 mins):Health News:Peach State Health Plan Presents $10,000 Check for “Be a Friend First” Anti-Bullying Program to Local Girl Scouts 2Health News:BioViva USA, Inc.’s Alzheimer’s Disease Gene Therapy Human Trial 2Health News:BioViva USA, Inc.’s Alzheimer’s Disease Gene Therapy Human Trial 3Health News:Heart Fit Clinic Helps Patient Increase Fitness Level with External Counterpulsation 2Health News:Mount Sinai Researchers Find Key Gene Drives Kidney Disease Severity 2Health News:Mount Sinai Researchers Find Key Gene Drives Kidney Disease Severity 3Health News:Q-Suite 5.9 Adds Validation Tools to Call Center Software Agent Screen 2
... has issued a warning to leave no stone unturned to ... health department found, nearly 20%// of the children under 12 ... snacks on a daily basis. Healthy options like fruits ... ,The Health Minister, John Hill, said "We're working with ...
... New research has been released by Australian obesity experts that ... the international conference on obesity in Sydney there were three ... cent reduction in mortality rates in obese people who had ... around the upper part of the stomach for the procedure ...
... A team of surgeons at Children's National Medical Centre ... conjoined twins who shared a spinal cord and were// ... reported that Mateo and McHale Shaw from Sheboygan, Wisconsin ... 12 hours into Wednesday night. The hospital authorities had ...
... that men have a 4- to 5-point IQ advantage over ... on 100,000 17- to 18-year-//olds on the Scholastic Assessment Test ... is not obvious because girls mature faster than boys. This ... years. ,145 items from the SAT were examined ...
... is not rude but on the contrary would improve concentration.// ... Stirling in Scotland, led by Gwyneth Doherty-Sneddon have concluded in ... British Journal of Developmental Psychology, that looking away or gazing ... ,In the study that was conducted on a ...
... a week might reduce the risk of heart disease significantly.// ... Cardiology stated that as little as two servings of eight grams ... reduce the risk of heart disease by as much as 11%. ... the same kinds of nuts five days a week only results ...
Cached Medicine News:Health News:Successfully Separated Conjoined Twins In A Critical Yet Stable Condition 2Health News:Greater g factor in men responsible for sex differences in general mental ability 2Health News:Greater g factor in men responsible for sex differences in general mental ability 3
(Date:7/31/2015)... According to a new market research report " Sterilization ... Filtration, E-beam, Gamma), Services (Onsite & Offsite), Consumables (Indicators, Detergents, ... 2020", published by MarketsandMarkets, The Sterilization Equipment Market is expected ... CAGR of 7.6%.from 2015 to 2020. Browse ... and 37 F igures spread ...
(Date:7/31/2015)... July 31, 2015 Egalet Corporation (Nasdaq: ... pharmaceutical company focused on developing, manufacturing and marketing ... its previously announced underwritten public offering of 7,666,667 ... offering price of $11.25 per share. The shares ... shares issued upon the exercise in full by ...
(Date:7/31/2015)... 2015  Xencor, Inc. (NASDAQ: XNCR ), a ... treatment of autoimmune diseases, asthma and allergic diseases, and ... Hata to its board of directors. ... development is a tremendous asset to our board," said ... officer of Xencor. "Xencor faces a range of opportunities ...
Breaking Medicine Technology:Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 2Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 3Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 4Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 2Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 3Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 4Xencor Appoints Yujiro S. Hata to Board of Directors 2Xencor Appoints Yujiro S. Hata to Board of Directors 3
Indications For Usage: , Emergency use. , When medicant during ventilation is required. ...
... Indications For Usage: ... ,The monitoring lumen is ... of tracheal gases especially end-tidal ... pressure. , Introducing medication. ...
Indications For Usage: ,Laser surgery of the larynx or other areas in close proximity to the tracheal tube using CO2 or KTP laser beam....
Indications For Usage: ,Airway management during pediatric surgical procedures and intensive care....
Medicine Products: