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Weight Gaining And Losing May Increase Men's Risk For Gallstones

According to a report in the November 27 issue of Archives of Internal Medicine, a JAMA/Archives journal, weight cycling may increase men's risk for gallstones later in// life. When a solid mass of cholesterol, bile and calcium salts gets accumulated in the gall bladder, it results in the Gallstone disease.

Around 25,000 men were targeted for the study and it was found that the associations remained when researchers considered each participant's body mass index (BMI), further suggesting that it is the weight cycling, rather than being overweight or obese alone, that increases risk.

Weight cycling occurs when one tries to lose weight and then regain the weight. To assess whether weight cycling influenced the risk of developing gallstones, Dr. Chung-Jyi Tsai, University of Kentucky College of Medicine Division of Digestive Diseases and Nutrition associate professor, and colleagues analyzed data from nearly 25,000 men who were part of the Health Professionals Follow-up Study.

The Study provided information about weight fluctuations in men between 1988 and 1992 by sending questionnaires every two years from 1992 to 2002 for monitoring whether they had developed gallstone disease. It was found that gallstones were more likely in men who experienced weight cycling than in those who maintained their weight. The risk of developing gallstones by 76 percent were seen in those who were classified as severe 'cyclers' lost and regained 20 pounds or more compared to weight maintainers.

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