Navigation Links
Weed Killer Plays a Pivotal Role in Those With Genetic Vulnerability to Parkinson’

Scientists have come out with a find that may make people even more wary of using agricultural chemicals in their gardens or farms//. Paraquat, a common chemical weed killer could be the hidden hand behind those suffering with Parkinson’s disease, at least those with certain genes that render them susceptible to one of the world’s most common neurological disorder.

In a study published in the Journal of Neuroscience, the researchers from the University of Alabama,conducted an experiment whereby they subjected fruit flies, known scientifically as Drosophila melanogaster, to low doses of paraquat. The scientists chose fruit flies as the animal models because these creatures have biochemical similarities to humans, particularly in regard to chemicals produced within their brain cells.

It was seen that on low dose ingestion of paraquat, certain neurons in the brain known as dopamine neurons, were almost totally wiped out or destroyed within a day.

These neurons produce the neuro transmitter dopamine. A paucity of dopamine caused by destruction of these neurons results in Parkinson’s diseases. No one knows till now what exactly causes the destruction of these neurons.

On ingestion of paraquat, the fruit flies began to demonstrate the tremors typical of Parkinsonism.

The research focused on select genes that influence dopamine synthesis and the release of dopamine from brain cells. The genes identified include those that regulate tetrahydrobiopterin, a compound that is required to make dopamine, as well as those involved directly in dopamine synthesis.

It was found that some flies, which had a mutated gene that resulted in the production of very little dopamine, were more susceptible to the effects of paraquat, while those with mutated genes that resulted in the production of too much dopamine were in fact resistant.

Another interesting find was that male flies were more vulnerable to the effe cts of paraquat. This draws a parallel to humans where men are the major sufferers.

Says Co- author Dr. Janis O’Donnell, about the study findings : “ Our hope is we can use this observation to discover other genes that might be influencing how these models, or human beings, might be more or less susceptible to these toxic agents.

" That’s exciting because it tells us that perhaps there are ways to exploit this, to identify different ways that people could be treated to help slow down the progress of this disease. By the time you discover a person has Parkinson’s disease, they have lost so many neurons, it’s almost impossible to reverse the trend. If you could predict it in advance, perhaps there would be some sort of therapy that could be applied to help protect those individuals.”

Source-Newswis
ANN
'"/>




Related medicine news :

1. Pain Killers Keep the Virus Away
2. Scientists found ancient Human Germ Killer
3. Domestic Violence: The Silent Killer of Women Worldwide
4. Intensive Search On For Nurse Killer
5. Hush…..A Deadly Killer on the Prowl in Rural Andhra Pradesh
6. Heart Related Problems-The Largest Killers In Andhra Pradesh
7. Beware Of A Silent Killer Called Haemophilia
8. Meet The Nurse With A Killer Instinct
9. Killer protein for anthrax bacteria discovered
10. Diabetes, The Silent Killer of New Zealand
11. Highly Pure Form Of heroin Proving To be lethal Killer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/18/2017)... ... August 18, 2017 , ... More than 20,000 pairs of shoes made their ... to an ambitious venture that conjoined the passions of an NBA star, a Liberty ... Liberty community. These shoes will save lives from the rampant infections transmitted through the ...
(Date:8/18/2017)... York, NY (PRWEB) , ... August 18, 2017 ... ... launch of this summer’s edition of “Vision & Hearing,” advocating for active, healthy ... campaign focuses on resources available for individuals with hearing impairments and shares the ...
(Date:8/18/2017)... ... August 18, 2017 , ... Hernandez ... consultations to communities throughout the greater DC region, is inaugurating a “New Leash ... rescuing local animals and training them to be companions for veterans in need. ...
(Date:8/18/2017)... ... 18, 2017 , ... The Brian Gifford Agency, an Indiana-based firm providing asset ... of Campagna Academy in a charity drive to provide for at-risk children and teens ... Campagna Academy is a nonprofit organization that has offered critical programs to at-risk and ...
(Date:8/18/2017)... ... August 18, 2017 , ... With over 16,000 active ... hormone replacement therapy and integrative medicine, has become a frontrunner for people seeking ... as menopause, andropause, thyroid disorder and adrenal insufficiencies. , Founded in 2003 ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... Aug. 15, 2017   Mostyn Law and Gulf Coast ... Houston, Texas . The Mostyn Law family has ... years. That is why Mostyn Law is partnering with ... to show its appreciation. Blood supplies are running low. ... short of hospital needs in August. That is why the blood ...
(Date:8/15/2017)... 15, 2017  AOTI Inc. announced today that its fully owned ... recently opened a New York City Office in Yonkers, ... unique Topical Wound Oxygen (TWO 2 ) homecare therapy. This new ... for Health Care (ACHC) under the company,s DMEPOS accreditation for Home/Durable ... Advanced ...
(Date:8/8/2017)... AVIV, Israel, Aug. 8, 2017  BioLineRx Ltd. (NASDAQ/TASE: ... immunology, today reports its financial results for the second ... achievements during the second quarter 2017 and to date: ... multiple clinical development programs for the Company,s lead project, ... 3 pivotal study with BL-8040 as novel stem cell ...
Breaking Medicine Technology: