Navigation Links
Weed Killer Plays a Pivotal Role in Those With Genetic Vulnerability to Parkinson’

Scientists have come out with a find that may make people even more wary of using agricultural chemicals in their gardens or farms//. Paraquat, a common chemical weed killer could be the hidden hand behind those suffering with Parkinson’s disease, at least those with certain genes that render them susceptible to one of the world’s most common neurological disorder.

In a study published in the Journal of Neuroscience, the researchers from the University of Alabama,conducted an experiment whereby they subjected fruit flies, known scientifically as Drosophila melanogaster, to low doses of paraquat. The scientists chose fruit flies as the animal models because these creatures have biochemical similarities to humans, particularly in regard to chemicals produced within their brain cells.

It was seen that on low dose ingestion of paraquat, certain neurons in the brain known as dopamine neurons, were almost totally wiped out or destroyed within a day.

These neurons produce the neuro transmitter dopamine. A paucity of dopamine caused by destruction of these neurons results in Parkinson’s diseases. No one knows till now what exactly causes the destruction of these neurons.

On ingestion of paraquat, the fruit flies began to demonstrate the tremors typical of Parkinsonism.

The research focused on select genes that influence dopamine synthesis and the release of dopamine from brain cells. The genes identified include those that regulate tetrahydrobiopterin, a compound that is required to make dopamine, as well as those involved directly in dopamine synthesis.

It was found that some flies, which had a mutated gene that resulted in the production of very little dopamine, were more susceptible to the effects of paraquat, while those with mutated genes that resulted in the production of too much dopamine were in fact resistant.

Another interesting find was that male flies were more vulnerable to the effe cts of paraquat. This draws a parallel to humans where men are the major sufferers.

Says Co- author Dr. Janis O’Donnell, about the study findings : “ Our hope is we can use this observation to discover other genes that might be influencing how these models, or human beings, might be more or less susceptible to these toxic agents.

" That’s exciting because it tells us that perhaps there are ways to exploit this, to identify different ways that people could be treated to help slow down the progress of this disease. By the time you discover a person has Parkinson’s disease, they have lost so many neurons, it’s almost impossible to reverse the trend. If you could predict it in advance, perhaps there would be some sort of therapy that could be applied to help protect those individuals.”

Source-Newswis
ANN
'"/>




Related medicine news :

1. Pain Killers Keep the Virus Away
2. Scientists found ancient Human Germ Killer
3. Domestic Violence: The Silent Killer of Women Worldwide
4. Intensive Search On For Nurse Killer
5. Hush…..A Deadly Killer on the Prowl in Rural Andhra Pradesh
6. Heart Related Problems-The Largest Killers In Andhra Pradesh
7. Beware Of A Silent Killer Called Haemophilia
8. Meet The Nurse With A Killer Instinct
9. Killer protein for anthrax bacteria discovered
10. Diabetes, The Silent Killer of New Zealand
11. Highly Pure Form Of heroin Proving To be lethal Killer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... HMP ... the recipient of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare ... City on October 11, 2017. , The annual award competition recognizes editorial and design ...
(Date:10/12/2017)... ... October 12, 2017 , ... On Saturday, October 21, the ... – Miles by Moonlight to raise money for the American Heart Association Heart Walk. ... , Teams will work together to keep their treadmills moving for 5 hours. Treadmills ...
(Date:10/12/2017)... ... October 12, 2017 , ... Health Literacy Innovations (HLI), ... software tool, and the Cancer Patient Education Network (CPEN), an independent professional organization ... a new strategic alliance. , As CPEN’s strategic partner, HLI will help ...
(Date:10/12/2017)... ... 2017 , ... Vohra Chief Medical Officer Dr. Shark Bird, ... nursing facility medical directors and other clinicians at various events in October. His ... many of these conferences we get to educate other physicians, facility nurses, corporate ...
(Date:10/12/2017)... ... October 12, 2017 , ... Vodori, ... Flow promotional review platform at the Promotional Review Committee Compliance and Best ... marketers streamline the medical, legal, and regulatory review (MLR) process – which ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... venture-backed medical device company developing a non-invasive, robotically assisted, platform therapy that uses pulsed sound ... ... Jim Bertolina, PhD ... Tom Tefft ... device executive Josh Stopek , PhD, who has led R&D and business development teams ...
(Date:9/18/2017)... Pa. and KALAMAZOO, Mich. , Sept. 18, ... , and OptiMed Specialty Pharmacy of ... to offer a strategic hub service that expedites and ... sought-after personal spirometer, Spiro PD 2.0, and wellness management ... spirometer is a medical device used to measure lung ...
(Date:9/13/2017)... , Sept. 13, 2017   OrthoAtlanta has ... the Atlanta Football Host Committee (AFHC) for the 2018 College ... Jan. 8, 2018, at Mercedes-Benz Stadium in Atlanta, ... of the AFHC "I,m In" campaign, participating in many activities ... ...
Breaking Medicine Technology: