Navigation Links
Weed Killer Plays a Pivotal Role in Those With Genetic Vulnerability to Parkinson’

Scientists have come out with a find that may make people even more wary of using agricultural chemicals in their gardens or farms//. Paraquat, a common chemical weed killer could be the hidden hand behind those suffering with Parkinson’s disease, at least those with certain genes that render them susceptible to one of the world’s most common neurological disorder.

In a study published in the Journal of Neuroscience, the researchers from the University of Alabama,conducted an experiment whereby they subjected fruit flies, known scientifically as Drosophila melanogaster, to low doses of paraquat. The scientists chose fruit flies as the animal models because these creatures have biochemical similarities to humans, particularly in regard to chemicals produced within their brain cells.

It was seen that on low dose ingestion of paraquat, certain neurons in the brain known as dopamine neurons, were almost totally wiped out or destroyed within a day.

These neurons produce the neuro transmitter dopamine. A paucity of dopamine caused by destruction of these neurons results in Parkinson’s diseases. No one knows till now what exactly causes the destruction of these neurons.

On ingestion of paraquat, the fruit flies began to demonstrate the tremors typical of Parkinsonism.

The research focused on select genes that influence dopamine synthesis and the release of dopamine from brain cells. The genes identified include those that regulate tetrahydrobiopterin, a compound that is required to make dopamine, as well as those involved directly in dopamine synthesis.

It was found that some flies, which had a mutated gene that resulted in the production of very little dopamine, were more susceptible to the effects of paraquat, while those with mutated genes that resulted in the production of too much dopamine were in fact resistant.

Another interesting find was that male flies were more vulnerable to the effe cts of paraquat. This draws a parallel to humans where men are the major sufferers.

Says Co- author Dr. Janis O’Donnell, about the study findings : “ Our hope is we can use this observation to discover other genes that might be influencing how these models, or human beings, might be more or less susceptible to these toxic agents.

" That’s exciting because it tells us that perhaps there are ways to exploit this, to identify different ways that people could be treated to help slow down the progress of this disease. By the time you discover a person has Parkinson’s disease, they have lost so many neurons, it’s almost impossible to reverse the trend. If you could predict it in advance, perhaps there would be some sort of therapy that could be applied to help protect those individuals.”

Source-Newswis
ANN
'"/>




Related medicine news :

1. Pain Killers Keep the Virus Away
2. Scientists found ancient Human Germ Killer
3. Domestic Violence: The Silent Killer of Women Worldwide
4. Intensive Search On For Nurse Killer
5. Hush…..A Deadly Killer on the Prowl in Rural Andhra Pradesh
6. Heart Related Problems-The Largest Killers In Andhra Pradesh
7. Beware Of A Silent Killer Called Haemophilia
8. Meet The Nurse With A Killer Instinct
9. Killer protein for anthrax bacteria discovered
10. Diabetes, The Silent Killer of New Zealand
11. Highly Pure Form Of heroin Proving To be lethal Killer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... California (PRWEB) , ... June 26, 2016 , ... Pixel ... Cut Pro X. , "Film editors can give their videos a whole new perspective ... Christina Austin - CEO of Pixel Film Studios. , ProSlice Levels contains over ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, can ... Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey ... cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as ... City area —Johnson is one of the first doctors to perform the treatment. ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Comfort Keepers® of ... Cancer Society and the Road To Recovery® program to drive cancer patients to and ... other adults to ensure the highest quality of life and ongoing independence. Getting ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the ... report to their offering. ... favourable commercial environment for MedImmune to enter. The US ageing ... serve to drive considerable growth for effective anti-influenza medications. The ... sales considerably, but development is still in its infancy. ...
(Date:6/23/2016)... BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a ... second affiliate in Latin America . ... ... ... ...
(Date:6/23/2016)... 2016 Research and Markets has ... Global Analysis (United States, China, Japan, Brazil, United Kingdom, ... their offering. Surgical ... business planners, provides surgical procedure volume data in a ... an in-depth analysis of growth drivers and inhibitors, including ...
Breaking Medicine Technology: