Navigation Links
Vitamin E Precursor Alpha-TOS Found Effective Against Breast Cancer Cells

A vitamin E precursor has been found to be effective to reduce tumor volume in breast cancer patients //with high levels of human epidermal growth factor receptor (HER2). Almost 30% of breast cancer patients show high levels of HER2.This is presumed to be the feature that makes the disease stubborn to many treatments including chemotherapy drugs.

Researchers in Griffith University’s School of Medical Science have recently shown that pro-vitamin E or alpha-tocopheryl succinate can decrease the tumor volume in experiments done on animals that had high levels of HER2. Chief investigator Associate Professor Jiri Neuzil said alpha-tocopheryl succinate (alpha-TOS) had the potential to be an inexpensive, safe and selective therapy for hard-to-treat breast cancers.

"Alpha-TOS has already shown promise as a potent anticancer agent in diseases such as colon cancer and mesothelioma. It induces controlled cell death or apoptosis in tumour cells."

Transgenic mice with high HER2 breast cancers were treated over a three week period and tumour size was monitored every three days by ultrasound imaging. The high resolution ultrasound allows for more accurate measurement of tumour volume than any other non-invasive technique.

The research team found that while alpha-TOS is effective alone, it can be delivered into the tumour cells more efficiently when given in a conjugate form with a targeting peptide.

"Tumour volume reduced more than 50% when animals were treated with the conjugate rather than free alpha-TOS," Associate Professor Neuzil said.

He said one of the benefits of alpha-TOS as a potential anti-cancer drug was that it was metabolised in the liver to vitamin E and unlikely to cause dangerous side effects. Associate Professor Neuzil is presenting his results at the Gold Coast Health and Medical Research Conference next week. The conference, an initiative of the Griffith Institute of Health and Medical Research, will be held December 14-15, at the Radisson Palm Meadows Resort, Gold Coast.



Source-Eurekalert
MST
'"/>




Related medicine news :

1. Vitamin B12 can help in detecting cancers
2. Vitamins-The answer to Heart Disease?
3. Vitamin E, the latest warrior against diabetes
4. Vitamin Shields Brittle Bones
5. B Vitamin protects and lowers toxicity of Arthritis Drug
6. B Vitamin Supplementatoin Saves Money and Lives
7. Eat Vitamin C and stay young
8. Vitamin C for the heart
9. Vitamin B for Hepatitis
10. Vitamins reduce pre-eclampsia
11. Vitamin E useful for Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2017)... ... June 23, 2017 , ... 21 Middle East and ... has selected 21 leaders from government, business and civil society in 11 countries across ... U.S. this fall, engaging in a transformative exchange of knowledge and ideas with the ...
(Date:6/23/2017)... ... June 23, 2017 , ... Ross Insurance ... With the Federal Emergency Management Agency’s (FEMA) recent update of flood zones, more ... 2012, the Biggert-Waters Act was enacted to reflect the actual risk in flood ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Katyl Agency, ... to families and business owners in and around Lackawanna County, is joining Meals ... in the area. , Meals on Wheels of NEPA provides hand-delivered and nutritious ...
(Date:6/23/2017)... ... June 23, 2017 , ... Radabaugh & Associates, a locally ... business owners in North Central West Virginia, is embarking on a cooperative charity ... residents in the region. , The Stepping Stones organization offers a series of ...
(Date:6/22/2017)... ... June 22, 2017 , ... Plastic Surgery Associates is proud to report ... 2017. Each year, research and information firm, Castle Connolly, releases their list of the ... this marks the 3rd time that Dr. Canales has been recognized by ...
Breaking Medicine News(10 mins):
(Date:5/29/2017)... 2017  Cellect Biotechnology Ltd. (NASDAQ: APOP ... the functional selection of stem cells, today provided a ... quarter ended March 31 st , 2017. ... the first quarter of 2017," said Dr. Shai Yarkoni, ... the treatment of the first blood cancer patient in ...
(Date:5/24/2017)... 2017  ivWatch LLC today announced the launch ... to enable seamless integration of ivWatch,s groundbreaking IV ... pumps and other devices. By integrating ivWatch technology ... help health care customers deliver a higher level ... IV therapy. "The ivWatch OEM Board ...
(Date:5/22/2017)... 22, 2017  As the specialty pharmacy industry ... to make the revolutionary shift from volume-based to ... ensuring positive patient outcomes and shaping the future ... focus away from clinical trials and toward data ... specialty drug therapy utilization in precise patient populations. ...
Breaking Medicine Technology: