Navigation Links
Vitamin E Precursor Alpha-TOS Found Effective Against Breast Cancer Cells

A vitamin E precursor has been found to be effective to reduce tumor volume in breast cancer patients //with high levels of human epidermal growth factor receptor (HER2). Almost 30% of breast cancer patients show high levels of HER2.This is presumed to be the feature that makes the disease stubborn to many treatments including chemotherapy drugs.

Researchers in Griffith University’s School of Medical Science have recently shown that pro-vitamin E or alpha-tocopheryl succinate can decrease the tumor volume in experiments done on animals that had high levels of HER2. Chief investigator Associate Professor Jiri Neuzil said alpha-tocopheryl succinate (alpha-TOS) had the potential to be an inexpensive, safe and selective therapy for hard-to-treat breast cancers.

"Alpha-TOS has already shown promise as a potent anticancer agent in diseases such as colon cancer and mesothelioma. It induces controlled cell death or apoptosis in tumour cells."

Transgenic mice with high HER2 breast cancers were treated over a three week period and tumour size was monitored every three days by ultrasound imaging. The high resolution ultrasound allows for more accurate measurement of tumour volume than any other non-invasive technique.

The research team found that while alpha-TOS is effective alone, it can be delivered into the tumour cells more efficiently when given in a conjugate form with a targeting peptide.

"Tumour volume reduced more than 50% when animals were treated with the conjugate rather than free alpha-TOS," Associate Professor Neuzil said.

He said one of the benefits of alpha-TOS as a potential anti-cancer drug was that it was metabolised in the liver to vitamin E and unlikely to cause dangerous side effects. Associate Professor Neuzil is presenting his results at the Gold Coast Health and Medical Research Conference next week. The conference, an initiative of the Griffith Institute of Health and Medical
'"/>




Page: 1 2

Related medicine news :

1. Vitamin B12 can help in detecting cancers
2. Vitamins-The answer to Heart Disease?
3. Vitamin E, the latest warrior against diabetes
4. Vitamin Shields Brittle Bones
5. B Vitamin protects and lowers toxicity of Arthritis Drug
6. B Vitamin Supplementatoin Saves Money and Lives
7. Eat Vitamin C and stay young
8. Vitamin C for the heart
9. Vitamin B for Hepatitis
10. Vitamins reduce pre-eclampsia
11. Vitamin E useful for Alzheimers
Post Your Comments:
(Date:9/17/2014)... Leading eco-friendly beauty brand , Lotus Moon, ... vegan and gluten-free Sugar Cane Fruit Mask. Their newest ... skincare testers were looking for. , “My goal ... that provided results, and I think I accomplished it,” ... Mask combines Willow bark (Salix Alba extract), a natural ...
(Date:9/17/2014)... 2014 The in vitro diagnostics (IVD) ... market, focusing on molecular diagnostics for conditions such as ... testing. The IVD market value is projected to be ... 2017. The major drivers of the market’s growth include ... is evidenced by the explosion for raid and minimally-invasive ...
(Date:9/17/2014)... (HealthDay News) -- Present-day Europeans are the descendants ... according to a new study. Previous ... and early European farmers. But, a new genetic ... also the descendants of Ancient North Eurasians. Nearly ... third ancestral group, researchers from Harvard Medical School ...
(Date:9/17/2014)... 17, 2014 (HealthDay News) -- Managing diabetes, quitting smoking, ... weight can reduce the risk for dementia -- even ... The World Alzheimer Report 2014, commissioned by Alzheimer,s Disease ... dementia by 50 percent. The study noted that obesity ... diabetes as well as high blood pressure. ...
(Date:9/17/2014)... Dennis Thompson HealthDay Reporter ... and dieters who turn to artificial sweeteners to soothe ... favors, a new Israeli study suggests. Artificial sweeteners ... no calories, researchers found in human and mouse studies. ... alter the bacteria residing in the intestines in ways ...
Breaking Medicine News(10 mins):Health News:EcoBeauty Brand Lotus Moon Unveils New Gluten-Free Sugar Cane Fruit Mask 2Health News:World In Vitro Diagnostics Market Analysed by VPG in In-demand Research Report Available at MarketPublishers.com 2Health News:World In Vitro Diagnostics Market Analysed by VPG in In-demand Research Report Available at MarketPublishers.com 3Health News:Europeans Are Descendants of at Least 3 Ancient Human Groups: Study 2Health News:Europeans Are Descendants of at Least 3 Ancient Human Groups: Study 3Health News:Healthy Lifestyle Changes Linked to Reduced Risk for Dementia 2Health News:Healthy Lifestyle Changes Linked to Reduced Risk for Dementia 3Health News:Artificial Sweeteners May Raise Blood Sugar Levels: Study 2Health News:Artificial Sweeteners May Raise Blood Sugar Levels: Study 3
... may benefit from HPV vaccine, study finds , TUESDAY, June ... for women aged 24 to 45 who aren,t already infected ... cancer and other cervical diseases. , That,s the finding from ... Bogota, Columbia, who noted that women,s rising age at first ...
... 2, 2009 Because bleeding from the reproductive tract ... women who exhibit menorrhagia, or excessive bleeding after their ... In order to address important issues related to the ... with bleeding disorders, a consensus conference was convened. Results ...
... use a new, cutting edge diagnostic technology to fight serious ... , WOBURN, Mass., and VEDBAEK, Denmark, June 2 AdvanDx ... Georgia has implemented AdvanDx,s PNA FISH(R) tests to identify bloodstream ... help their physicians, pharmacists and nurses improve care and outcomes ...
... Reporting Now Available Through CSC,s FirstPortfolio Offering , ... CSC ) today announced that it has ... to include fully integrated Medicare Secondary Payer (MSP) reporting ... of applications hosted and maintained by CSC. , ...
... Couple,s Struggle with Alzheimer,s , , WASHINGTONVILLE, N.Y., June 2 ... over 5 million Americans currently living with Alzheimer,s disease and the ... to announce the release of her book, "Released to the Angels: ... ). , , "Released to the Angels" is an ...
... 2 Rules-Based Medicine, Incorporated (RBM), the leading biomarker ... has joined the Company as vice president, clinical diagnostics. ... as RBM commercializes new biomarker-based diagnostic tests. ... biomarker assays for improved drug development, has programs to ...
Cached Medicine News:Health News:Cervical Cancer Vaccine Not Just for Teens 2Health News:Experts reach consensus on diagnosis and treatment of bleeding disorders in women 2Health News:Memorial University Medical Center (MUMC) Implements PNA FISH(R) Tests to Help Provide Best Care for Patients with Bloodstream Infections 2Health News:Memorial University Medical Center (MUMC) Implements PNA FISH(R) Tests to Help Provide Best Care for Patients with Bloodstream Infections 3Health News:CSC Offers Medicare Secondary Payer Reporting to Health Plans 2Health News:The Unexpected Gifts of Alzheimer's 2Health News:The Unexpected Gifts of Alzheimer's 3Health News:Rules-Based Medicine, Inc. Names Tony Barnes to Lead Expanding Diagnostics Business 2
(Date:9/17/2014)... , Sept. 17, 2014 BRIC Gynecological ... GlobalData,s new report, "BRIC Gynecological ... data on the BRIC Gynecological Devices market. The ... volume (in units) and average prices (in US ... (Transcervical Sterilization Devices (Micro-inserts) and Mechanical Sterilization Devices ...
(Date:9/17/2014)... Sept. 17, 2014  Dr. Stephen Loyd , ... House today for National Recovery Month, stars in a ... released today. Consumer advocates were also joined by a ... out after losing her fiancée because of a preventable ... had a history of crack cocaine abuse. Proposition 46 ...
(Date:9/17/2014)... Bronstein, Gewirtz & Grossman, LLC is investigating ... of PDL BioPharma, Inc. ("PDL BioPharma" or the "Company") ... advised to contact Peretz Bronstein or his ... info@bgandg.com or 212-697-6484. The investigation focuses ... violated federal securities laws. On September 16, ...
Breaking Medicine Technology:BRIC Gynecological Devices Market Outlook to 2020 2BRIC Gynecological Devices Market Outlook to 2020 3Doctor Recovering From 100-Pill-A-Day Addiction Stars In New Ad Supporting Prop 46; Appears At White House for National Recovery Month, Says Consumer Watchdog Campaign 2Doctor Recovering From 100-Pill-A-Day Addiction Stars In New Ad Supporting Prop 46; Appears At White House for National Recovery Month, Says Consumer Watchdog Campaign 3Shareholder Alert: Bronstein, Gewirtz & Grossman, LLC Investigates claims on behalf of Investors of PDL BioPharma, Inc. --PDLI 2
... SLTM ), the pioneer in fractional resurfacing and ... treatments, today announced it has received FDA 510(k) clearance of ... Dual for the treatment of actinic keratosis (AKs). ... laser technology to the next level by adding a novel ...
... ResMed (NYSE: RMD ), ... and respiratory medical equipment today announced the results ... with sleep therapy increases when using ResMed,s new ... (Logo:   http://www.newscom.com/cgi-bin/prnh/20100203/RESMEDLOGO ) ...
Cached Medicine Technology:Solta Medical Announces FDA 510(k) Clearance of Fraxel re:store Dual Laser System for the Treatment of Actinic Keratosis 2Solta Medical Announces FDA 510(k) Clearance of Fraxel re:store Dual Laser System for the Treatment of Actinic Keratosis 3Study Shows ResMed's New CPAP Device Increases Patient Compliance 2Study Shows ResMed's New CPAP Device Increases Patient Compliance 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: