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Vitamin D3 Protects Skin from Harmful Microbes

lows infections to develop more readily.

“Our finding – that multiple, diverse genes controlled by 1,25D3 are increased after injury to the skin – suggests that the availability of D3 is essential to the wound. These responses are a previously unrecognized part of the human injury response,” said Gallo.

Lower concentrations of 1,25D3 in African Americans, likely due to a decreased ability to absorb vitamin D from sunlight, correlate with increased susceptibility to infection. In addition, 1,25D3 has been suggested to be an immune-modifying agent in pulmonary tuberculosis.

As a result of this and previous studies, Gallo and his colleagues are beginning clinical trials at UCSD Medical Center with both oral and topical vitamin D3. Normal volunteers, and patients with disorders in antimicrobial peptide production such as atopic dermatitis and acne, are being studied to determine if vitamin D3 can improve their natural immune defenses.

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