Navigation Links
Vitamin D3 Protects Skin from Harmful Microbes

A study shows that fluctuations in Vitamin D3 levels control the body’s innate immune response//, affecting a skin wound’s ability to heal.

Richard L. Gallo, M.D., Ph.D., professor of medicine and chief of UCSD’s Division of Dermatology and the Dermatology section of the Veterans Affairs San Diego Healthcare System, says that several unexpected associations between fluctuations of the body’s vitamin D3 and infectious disease have emerged in recent investigations.

In a study appearing online February 8 in advance of publication in the March issue of the Journal of Clinical Investigation, Gallo and his colleagues look at how the innate immune system is controlled in the skin, and find that genes controlled by active vitamin D3 play an essential role in the process.

“Our study shows that skin wounds need vitamin D3 to protect against infection and begin the normal repair process,” said Gallo. “A deficiency in active D3 may compromise the body’s innate immune system which works to resist infection, making a patient more vulnerable to microbes.”

Gallo’s lab discovered that an antimicrobial peptide called cathelicidin is produced by wounds and is necessary to fight infections. Recently, several studies have begun to link vitamin D to cathelicidin. Researchers focused on white blood cells called macrophages that work to destroy invading bacterial microbes.

Macrophages contain toll-like receptors that identify the invaders; when the receptors sense the presence of bacteria, they trigger cathelicidin production.

Gallo’s team has now discovered that injury stimulates skin cells called keratinocytes, which surround the wound, to increase the production of vitamin D3 and that this in turn increases the expression of genes (CD14 and TLR2) that detect microbes. These genes, together with active vitamin D3, called 1,25D3, then lead to more cathelicidin. In both mice and humans, a deficiency in cathelicidin al
'"/>




Page: 1 2

Related medicine news :

1. Vitamin B12 can help in detecting cancers
2. Vitamins-The answer to Heart Disease?
3. Vitamin E, the latest warrior against diabetes
4. Vitamin Shields Brittle Bones
5. B Vitamin protects and lowers toxicity of Arthritis Drug
6. B Vitamin Supplementatoin Saves Money and Lives
7. Eat Vitamin C and stay young
8. Vitamin C for the heart
9. Vitamin B for Hepatitis
10. Vitamins reduce pre-eclampsia
11. Vitamin E useful for Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Vitamin Protects Skin from Harmful Microbes

(Date:7/31/2015)... ... ... The Radiology Business Management Association’s 2015 Fall Educational Conference ... A View From Capitol Hill” on Sunday, Sept. 27, 2015, in Austin, Tex. ... a special understanding of the real world impact of health care policy issues,” said ...
(Date:7/31/2015)... ... July 31, 2015 , ... An article entitled ... talked about a woman’s unfortunate experience having cosmetic skin procedures done by a ... resulted in blistering, swelling, bruising, and pain. This woman’s experience is only one ...
(Date:7/31/2015)... ... ... “ Crack’em ” was featured on NewsWatch as part of its monthly ... Forstrom, a technology expert and special reporter for NewsWatch, conducted the review and shared ... can be a very messy experience, especially when cracking eggs. Cracking an egg is ...
(Date:7/31/2015)... Georgia (PRWEB) , ... July 31, 2015 , ... Super-Sod ... Houzz.com with a Super-Sod Pro Page as the perfect fit for such ... via pictures and articles. The social website is a dynamic site that spreads home ...
(Date:7/31/2015)... ... July 31, 2015 , ... In the most recent testosterone ... in the Northern District of Illinois, Androgel testosterone attorneys report that a “Mini Status ... entry was made recording the minutes of the status conference, which was held that ...
Breaking Medicine News(10 mins):Health News:Congressional Health Caucus Founder Rep. Michael Burgess, MD, to Speak at RBMA Fall Educational Conference 2Health News:Congressional Health Caucus Founder Rep. Michael Burgess, MD, to Speak at RBMA Fall Educational Conference 3Health News:Dermatologists Discuss Rise in Unqualified Practitioners of Cosmetic Dermatology 2Health News:Dermatologists Discuss Rise in Unqualified Practitioners of Cosmetic Dermatology 3Health News:Make Less Mess while Cooking with Crack’em 2Health News:Super-Sod Created a Landscape Profile on Houzz.com for Home Garden Design 2Health News:Testosterone Lawsuit News: Androgel Lawsuit Conference Held 2Health News:Testosterone Lawsuit News: Androgel Lawsuit Conference Held 3Health News:Testosterone Lawsuit News: Androgel Lawsuit Conference Held 4
... A new study shows fitness may be more important at ... or obese.// Previous research has not been clear on the ... The obesity studies have failed to look at fitness levels ... at the relationship between physical fitness and obesity with heart ...
... foods because they think they're fattening are mistaken, say ... ,Researchers say 9-year-old girls who consumed ... put on additional pounds than kids the same age ... in calcium significantly improved their intake of essential nutrients. ...
... diagnosis was a stronger predictor of heart disease than ... fibrinogen (a clotting factor), low HDL (“good”) cholesterol or ... data of 256 cardiac patients to 250 non-cardiac patients ... the strongest predictor of coronary disease was pericoronitis, an ...
... may offer a faster and easier way to protect ... event of // a deadly bioterror attack. Scientists have ... potentially be inhaled through the nose, thus eliminating needle ... anthrax recombinant protective antigen (rPA), a genetically engineered protein. ...
... larger radiation doses to the organs than conventional X-rays. The ... nearly 100 times that of a typical mammogram. A new ... full-body CT scan is just slightly less than the cancer ... in Japan. ,The study also shows elective annual ...
... 40 are five-times more likely to suffer a heart attack ... disease cases of study participants between the ages of 33 ... and 4,047 were women. ,Results showed 80 percent of ... the ages of 35 and 39.In the study, smoking also ...
Cached Medicine News:
(Date:7/31/2015)... July 31, 2015 Magnaquest, ... video, data and cloud computing operators has signed ... pharma giant for Internet of Things (IoT) related ... offered on subscription model.      (Logo: ... is striving for business innovations to make healthcare ...
(Date:7/30/2015)... 30, 2015 Edwards Lifesciences Corporation (NYSE: EW ... and hemodynamic monitoring, today announced that Robert A. Ingram ... "Bob is an ardent champion for innovation in the ... have him on Edwards, board as we pursue our focused ... and CEO.  "Bob has provided a valuable perspective to our ...
(Date:7/30/2015)... July 30, 2015 Mettler-Toledo International Inc. (NYSE: ... 2015.  Provided below are the highlights: , ... compared with the prior year. Reported sales decreased 4% ... quarter. , Net earnings per diluted share as ... prior-year period. Adjusted EPS was $2.80 , an ...
Breaking Medicine Technology:Magnaquest Signs a POC With a Leading Pharma Giant in Europe to Manage Subscription Management and Billing for Internet of Things (IoT) 2Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 2Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 3Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 4Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 5Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 6Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 7Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 8Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 9Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 10Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 11Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 12Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 13Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 14
... sectioning work, it is necessary to cool a ... can be fitted to most microtomes and will ... lower, depending on conditions. The equipment consists of ... cooling stage is best suited for operation with ...
... & 4405 series Freezing Stages fit easily onto ... moving parts and need only the AC supply ... Freezing starts immediately and can be ... that optimum cutting temperatures can be set for ...
ELISA kit for the quantitative determination of autoantibodies to IA-2 in serum...
Inquire...
Medicine Products: