Navigation Links
Vitamin D May Help In Fight Against Tuberculosis

A new research has offered insights into why Africans have an increased susceptibility to tuberculosis and have severe manifestation of the disease compared to whites. // Worldwide, approximately more than 8 million people are afflicted with TB and over 2 million people die due to the same every year. The disease is caused by Mycobacterium tuberculosis. According to official sources, the incidence of TB is eight times higher in African Americans than whites.

Innate immunity is the natural ability of the body to fight specific molecules found on microorganisms. This progressive ability has been achieved through the evolutionary process. It has been known from previous studies that mice effectively combat the tubercle bacillus by production of nitric oxide in macrophages, the so-called scavenger cells of the immune system. This mechanism is however poorly understood in human beings.

Human macrophages have a set of receptors (toll like receptors) that contribute to innate immunity. It ahs now been shown that this may be to a large extent dependent on absorption, storage and utilization of Vitamin D. Stimulation of toll like receptors by specific molecules of the tubercle bacillus activates an enzyme (Cyp27B1) and Vitamin D receptors, resulting in conversion of inactive form of the vitamin to active form.

This dual activation induces cleavage of a preexistent protein to cathelicidin (a small peptide), capable of destroying TB bacilli in a test tube. This vitamin D production effect cannot take place without exposure to ultraviolet light.

African Americans have high levels of melanin, a skin pigment that absorbs UV light. This limits the intrinsic ability of vitamin D production. Consistent with the theory, in vitro culture of cells of African Americans were found to produce lowered levels of cathelicin (63%), compared to those of the whites.

The result of the present study has enabled scientists to unr avel two major mysteries associated with Tuberculosis. One, the diversity of the mice and human anti-bacterial mechanism, and two, the increased susceptibility of Africans and Asian to TB. The researchers have highlighted the need for clinical trials to investigate the beneficial effect of Vitamin D supplementation in prevention of TB.

If successful, we might perhaps be one day able to modify an individual’s susceptibility to TB, more specifically in the vulnerable population by supplementation of vitamin either through diet or a cheap vitamin pill.


'"/>




Related medicine news :

1. Vitamin B12 can help in detecting cancers
2. Vitamins-The answer to Heart Disease?
3. Vitamin E, the latest warrior against diabetes
4. Vitamin Shields Brittle Bones
5. B Vitamin protects and lowers toxicity of Arthritis Drug
6. B Vitamin Supplementatoin Saves Money and Lives
7. Eat Vitamin C and stay young
8. Vitamin C for the heart
9. Vitamin B for Hepatitis
10. Vitamins reduce pre-eclampsia
11. Vitamin E useful for Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... Milwaukee, WI (PRWEB) , ... October 13, 2017 , ... ... movement in medicine known as “patient engagement.” The patient is doing more than filling ... research partners. , “There is an increasing emphasis in health care and research ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Pharmacy (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, ... guideline updates for the primary prevention of cardiovascular diseases during the 15th ...
(Date:10/13/2017)... ... 13, 2017 , ... Ellevate Network, the leading network for professional women, brought ... gender equality at their inaugural Summit in New York City in June. The event ... audience of over 3 million. To watch the Mobilize Women video, click here ...
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of a ... “The Journey: From the Mountains to the Mission Field” is the creation of published ... all ages and currently teaches a class of ladies at her church, which she ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has ... today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every formula ... the highest standard. , These products are also: Gluten Free, Non-GMO, Vegan, ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2017 Diplomat Pharmacy, Inc. (NYSE: ... Consulting, LLC , and named its founder as Diplomat,s ... Tennessee , will operate under Diplomat ... service offerings for health care partners to include IT ... "In an interoperable world, technology delivers comprehensive ...
(Date:10/2/2017)... 2, 2017  AllianceRx Walgreens Prime, the combined central ... and pharmacy benefit manager Prime Therapeutics LLC (Prime), today ... included the unveiling of new signage at its headquarters ... as at a few other company-owned facilities across the ... patients, some of whom will begin to see the ...
(Date:10/2/2017)... Denmark , Oct. 2, 2017 The Rebound ... in the struggle to reverse the tide of prescription drug ... for regulating their medicine intake and stepping down their dosage ... set to launch in December 2017; the first 100,000 people ... Learn more at http://www.rebound-solution.com/ ...
Breaking Medicine Technology: