Navigation Links
Virus may Be the Cause of Mad Cow

A study disputes the theory that deformed proteins are to blame for the brain disease. According to a study released Monday, Mad Cow disease and other related brain disorders// may be caused by a virus and not the weird, misshapen proteins, known as prions, that scientists think are responsible.

Researchers reported that they found virus-like particles in mouse nerve cells infected with two brain-wasting diseases similar to mad cow disease, but found no traces of the particles in uninfected cells.

Lead author Dr. Laura Manuelidis, a neuropathologist at Yale University, said the finding suggested that prions in infected brains were the result of a viral infection and not the cause of the disease.

"We found something that people have been ignoring," Manuelidis said of the virus particles. "What we hypothesize is the simplest, most parsimonious point of view."

Several brain researchers were skeptical about Manuelidis' findings, published in the Proceedings of the National Academy of Sciences.

"It's very remarkable that we only see these particles after infection of these cells," said Bob Rohwer, director of the Molecular Neurovirology Laboratory at the Veterans Affairs Medical Center in Baltimore, who was not involved in the study. "But the evidence that they are in fact the infectious agent responsible is still highly circumstantial."

Mad cow disease, known formally as bovine spongiform encephalopathy, is a cattle disease that destroys brain tissue by causing abnormal tangles of protein fibers and creating microscopic holes in the brain.

It is part of a family of slow-developing brain diseases, including scrapie in sheep and Creutzfeldt-Jakob disease in humans. Human infection in recent years has been connected to eating infected meat. There have been dozens of fatalities over the years.

The prion theory of mad cow disease proposes that a normal protein spontaneously misfol ds, starting a cascade of abnormal changes in other proteins.

In Manuelidis' previous experiments, prions did not appear until late in the progression of spongy brain diseases.

To find what appears at an earlier phase, Manuelidis' team homogenized mouse brains infected with scrapie and Creutzfeldt-Jakob disease and injected them into nerve cell cultures.

The only new objects were dense spheres that looked like small viruses, she said.

She later added a compound to spur the growth of prions about fivefold to see if that would increase the level of infection. The level did not show a significant increase, suggesting that prions were not the active agent of infection, she said.

To prove that the virus-like particles are solely responsible for the infection, Manuelidis plans to isolate the particles and see if they can start an infection when injected into healthy cells.

Source-Bio-Bio Technology
SRI
'"/>




Related medicine news :

1. Virus Level could Predict Cervical Cancer Risk
2. Ebola Virus - Outbreak Claims More Lives In Uganda.
3. Experimental treatment for Ebola Virus Shows promising results in mice
4. Virus Combats Brain Tumour
5. Virus killer
6. Pain Killers Keep the Virus Away
7. Measles Suppresses AIDS Virus
8. Virus connection to cervical injury
9. Virus Helps Remove Brain Cancer
10. Origin Of SARS Virus Discovered
11. New Molecule that can stop the growth of Viruses
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/20/2017)... ... ... Dr. Jig Patel is pleased to announce openings for new patients who ... the difficulties that face people who are missing teeth , he offers education ... dentures and bridges. Not only does an implant improve oral health, it also restores ...
(Date:7/20/2017)... ... July 19, 2017 , ... Med Tech Solutions (MTS), a leading health care ... unit of Constellation Inc., a move that will help the company better serve its ... Louis, the acquisition is expected to help MTS expand its presence in ...
(Date:7/20/2017)... ... July 19, 2017 , ... Adolfson & Peterson Construction ... Josh Christensen. As a leader in healthcare construction, AP has successfully built several ... in the Midwest with Josh now on board. , Josh brings over ...
(Date:7/20/2017)... ... July 19, 2017 , ... ... may sometimes lead to, or worsen, varicose veins in some patients, according to ... while avoiding certain not-so-good practices, like excessive sitting or standing, or regularly nicking ...
(Date:7/20/2017)... ... July 20, 2017 , ... “Lucky the Buffalo and Her Adventures”: a collection of heartwarming ... Edward Bieniek. Edward Steven Bieniek Jr. was born in Toledo, Ohio. He attended ... com tech. He is married to a brilliant woman with a caring heart named ...
Breaking Medicine News(10 mins):
(Date:7/14/2017)... July 14, 2017 Endo International plc (NASDAQ: ... August 8, 2017.  Members of its senior management team will host ... at 8:30 a.m. ET. The dial-in number to ... International (678) 509-7598, and the passcode is 45397076. Please dial in ... A replay of the call will be ...
(Date:7/13/2017)... FREMONT, Calif. , July 13, 2017 RK ... (CA) Board of Pharmacy certification for its Fremont, ... chain support solutions in the Tri-Valley and San ... The City of Fremont , with its ... Logistics Group to provide such a powerful resource to the ...
(Date:7/12/2017)... INDIANAPOLIS , July 12, 2017  Eli Lilly and ... settlement agreement with generic companies to resolve pending patent litigation ... Virginia regarding the Cialis ® ... expire on April 26, 2020. As part of the agreement, ... on September 27, 2018. "The unit dose patent ...
Breaking Medicine Technology: