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Virus may Be the Cause of Mad Cow

A study disputes the theory that deformed proteins are to blame for the brain disease. According to a study released Monday, Mad Cow disease and other related brain disorders// may be caused by a virus and not the weird, misshapen proteins, known as prions, that scientists think are responsible.

Researchers reported that they found virus-like particles in mouse nerve cells infected with two brain-wasting diseases similar to mad cow disease, but found no traces of the particles in uninfected cells.

Lead author Dr. Laura Manuelidis, a neuropathologist at Yale University, said the finding suggested that prions in infected brains were the result of a viral infection and not the cause of the disease.

"We found something that people have been ignoring," Manuelidis said of the virus particles. "What we hypothesize is the simplest, most parsimonious point of view."

Several brain researchers were skeptical about Manuelidis' findings, published in the Proceedings of the National Academy of Sciences.

"It's very remarkable that we only see these particles after infection of these cells," said Bob Rohwer, director of the Molecular Neurovirology Laboratory at the Veterans Affairs Medical Center in Baltimore, who was not involved in the study. "But the evidence that they are in fact the infectious agent responsible is still highly circumstantial."

Mad cow disease, known formally as bovine spongiform encephalopathy, is a cattle disease that destroys brain tissue by causing abnormal tangles of protein fibers and creating microscopic holes in the brain.

It is part of a family of slow-developing brain diseases, including scrapie in sheep and Creutzfeldt-Jakob disease in humans. Human infection in recent years has been connected to eating infected meat. There have been dozens of fatalities over the years.

The prion theory of mad cow disease proposes that a normal protein spontaneously misfol
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