Navigation Links
Virus may Be the Cause of Mad Cow

A study disputes the theory that deformed proteins are to blame for the brain disease. According to a study released Monday, Mad Cow disease and other related brain disorders// may be caused by a virus and not the weird, misshapen proteins, known as prions, that scientists think are responsible.

Researchers reported that they found virus-like particles in mouse nerve cells infected with two brain-wasting diseases similar to mad cow disease, but found no traces of the particles in uninfected cells.

Lead author Dr. Laura Manuelidis, a neuropathologist at Yale University, said the finding suggested that prions in infected brains were the result of a viral infection and not the cause of the disease.

"We found something that people have been ignoring," Manuelidis said of the virus particles. "What we hypothesize is the simplest, most parsimonious point of view."

Several brain researchers were skeptical about Manuelidis' findings, published in the Proceedings of the National Academy of Sciences.

"It's very remarkable that we only see these particles after infection of these cells," said Bob Rohwer, director of the Molecular Neurovirology Laboratory at the Veterans Affairs Medical Center in Baltimore, who was not involved in the study. "But the evidence that they are in fact the infectious agent responsible is still highly circumstantial."

Mad cow disease, known formally as bovine spongiform encephalopathy, is a cattle disease that destroys brain tissue by causing abnormal tangles of protein fibers and creating microscopic holes in the brain.

It is part of a family of slow-developing brain diseases, including scrapie in sheep and Creutzfeldt-Jakob disease in humans. Human infection in recent years has been connected to eating infected meat. There have been dozens of fatalities over the years.

The prion theory of mad cow disease proposes that a normal protein spontaneously misfol ds, starting a cascade of abnormal changes in other proteins.

In Manuelidis' previous experiments, prions did not appear until late in the progression of spongy brain diseases.

To find what appears at an earlier phase, Manuelidis' team homogenized mouse brains infected with scrapie and Creutzfeldt-Jakob disease and injected them into nerve cell cultures.

The only new objects were dense spheres that looked like small viruses, she said.

She later added a compound to spur the growth of prions about fivefold to see if that would increase the level of infection. The level did not show a significant increase, suggesting that prions were not the active agent of infection, she said.

To prove that the virus-like particles are solely responsible for the infection, Manuelidis plans to isolate the particles and see if they can start an infection when injected into healthy cells.

Source-Bio-Bio Technology

Related medicine news :

1. Virus Level could Predict Cervical Cancer Risk
2. Ebola Virus - Outbreak Claims More Lives In Uganda.
3. Experimental treatment for Ebola Virus Shows promising results in mice
4. Virus Combats Brain Tumour
5. Virus killer
6. Pain Killers Keep the Virus Away
7. Measles Suppresses AIDS Virus
8. Virus connection to cervical injury
9. Virus Helps Remove Brain Cancer
10. Origin Of SARS Virus Discovered
11. New Molecule that can stop the growth of Viruses
Post Your Comments:

(Date:12/1/2015)... (PRWEB) , ... December 02, 2015 , ... Ruth Pearson ... brutal lupus flare-up. Unable to walk without assistance and quickly losing hope of recovering ... then a miracle happened. , Pearson was attending a women’s retreat when she experienced ...
(Date:12/1/2015)... ... December 01, 2015 , ... The Multiple System Atrophy Coalition ... funds for Multiple System Atrophy (MSA) research, timed today to coincide with Giving Tuesday ... from patients including their ability to work and be productive, to do simple daily ...
(Date:12/1/2015)... , ... December 01, 2015 , ... Royal River Natural ... new study that found post-menopausal women who took the nutritional supplement creatine, along with ... who trained but did not take creatine. , The report is part of the ...
(Date:12/1/2015)... , ... December 01, 2015 , ... ... leadless pacemakers in the U.S. and is the only hospital in the region ... largest clinical data presentation of transcatheter pacing patients were revealed recently at a ...
(Date:12/1/2015)... ... 01, 2015 , ... December 1, 2015 -- InstantLabs is ... growing product line of food safety and seafood fraud prevention tools. , The ... allow InstantLabs to offer fast, reliable species identification for the four most popular ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... Russia has always been a ... new drugs registered in Europe in 2015 were ... Russia has always been a country of choice ... in Europe in 2015 were tested in phase ... Russia has always been a country of choice for global ...
(Date:12/1/2015)... , Dec. 1, 2015 CytRx Corporation (NASDAQ: ... specializing in oncology, today announced that it has reached ... pivotal global Phase 3 clinical trial of aldoxorubicin in ... originally estimated to be completed in Q1 2016. The Phase ... under a Special Protocol Assessment from the FDA at ...
(Date:12/1/2015)... 1, 2015  The migration to value-based care ... care plans that help patients stay healthy and ... be digitally enabled, incorporate care guidelines and be ... They will also allow all stakeholders to collaborate ... is optimal. That is the vision, however, research ...
Breaking Medicine Technology: