Navigation Links
Veterans Exposed to Agent Orange Increased Risk of Prostate Cancer Recurrence

Veterans exposed to Agent Orange have a 48 percent increased risk of prostate cancer recurrence following surgery than their unexposed peers , and when the disease comes back, it seems more aggressive, researchers say.

"We need to be screening these patients earlier, treating their cancer aggressively and following them closely afterward because they are at higher risk for recurrence," says Dr. Martha Terris, chief of the Urology Department at the Augusta Veterans Affairs Medical Center and professor of urology at the Medical College of Georgia.

"We looked at all patients, whether they were exposed or not, to see which were more likely to develop a recurrence and patients with a history of Agent Orange exposure were more likely," says Dr. Sagar R. Shah, MCG urology resident who is presenting the data May 20 during the American Urological Association Annual Meeting in Anaheim, Calif.

The study looked at 1,653 veterans who had prostate cancer surgery at Department of Veterans Affairs Medical Centers in five cities between 1990 and 2006; 199 had been exposed to Agent Orange, a herbicide and defoliant sprayed on the dense forests of Vietnam during the war.

Agent Orange contains the carcinogen, dioxin, which can be stored in body fat and is believed to make its way into the cell nucleus and work as a tumor promoter. In the past, relatively higher mortality rates have been found in chemical plant workers and farmers with prostate cancer who were exposed to dioxin, the researchers write in their abstract.

Dioxins impact is dose-related, and while the researchers did not measure levels of dioxin or Agent Orange, they suspect that blacks, who were more likely to be ground troops, also were more likely to have had more Agent Orange exposure.

Researchers found veterans with Agent Orange exposure more likely to be black and younger at the time of surgery to remove their prostate gland. The disea se appeared to be caught earlier in exposed veterans. Most had their disease staged as T1 by pathologists, which means it appeared confined to the prostate gland, and had lower pre-operative prostate specific antigen scores, an indicator of disease aggressiveness.

However, when the disease recurred, exposed veterans experienced a more rapid biochemical progression of their disease, which PSA measures. In blacks, the PSA doubled in almost half the time of their unexposed peers.

A blood PSA level screens for prostate cancer for most men beginning at age 50 and at age 40 for blacks and men with a family history. Black men have been shown by Dr. Terris and others to have more aggressive disease earlier in life.

To account for known racial differences, researchers also compared recurrence rates in exposed and non-exposed blacks and whites and the results held up.

"As a population in general, if you were exposed to Agent Orange, youre more likely to have a recurrence," says Dr. Shah. "If you were black and exposed, you were more likely to recur than if you were black and unexposed."

If it sounds odd that men who had their prostate removed could have disease recurrence, Dr. Terris points out that microscopic cancer cells can migrate out of the area before surgery, becoming detectable later when they start pushing PSA levels back up.

In fact, following any type of prostate cancer treatment, men routinely get PSA levels checked for the rest of their lives. Without cancer recurrence, they should stay at zero.


'"/>




Related medicine news :

1. Military Veterans Suffer From Increased Risk of Heart Diseases
2. American War Veterans Not Receiving Enough Care For PTSD
3. Veterans To Get Improved Access To GP Care
4. Gulf War Veterans Exhibit Memory Impairment
5. Gulf War Veterans Exhibit Memory Impairment
6. Moves To Improve War Veterans Health Taken
7. Activists Urge Greater Medical Support for Gulf War Veterans Exposed to Sarin Gas
8. HIV Positive Men in Singapore Exposed
9. Kate Moss Glad her Drug Addiction was Exposed
10. Australian Children Not Being Exposed To Enough Sunlight
11. Lakhs of Indians Exposed to High Levels of Poisonous Gases
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... 2017 , ... The American Board of Family Medicine's (ABFM) Board of Directors ... Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. Newton will serve in ... retirement at the end of 2018. Upon assuming the role of President and CEO ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has released ... understood books in the Holy Scriptures, Revelation. The Book of Revelation paints a picture ... Many have tossed it off as mere rubbish, but Yisrayl Hawkins says that is ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare ... program management, will showcase a range of technology and learning solutions at the ... Convention and Expo to be held October 14–18, 2017 at the Mandalay Bay ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical ... Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. ... honor of Morris F. Collen, a pioneer in the field of medical informatics, this ...
Breaking Medicine News(10 mins):
(Date:10/7/2017)... 2017   Provista, a proven leader in ... in purchasing power, today announced a new resource area ... Newsroom is the online home for case studies, ... bios, news releases, slideshows and events. ... of resources at their fingertips, viewers can also watch ...
(Date:10/2/2017)... , Oct. 2, 2017 Diplomat Pharmacy, Inc. ... Day Software and Consulting, LLC , and named its ... Software, based in Tennessee , will ... Day expands EnvoyHealth,s service offerings for health care partners ... "In an interoperable world, ...
(Date:9/28/2017)... 2017 Hill-Rom Holdings, Inc. (NYSE: HRC), will ... and webcast on Friday, November 3, 2017, beginning at ... at approximately 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... financial performance and guidance for 2018, Hill-Rom executives will ... operational performance, and long-range financial outlook through 2020. ...
Breaking Medicine Technology: