Navigation Links
Veterans Exposed to Agent Orange Increased Risk of Prostate Cancer Recurrence

Veterans exposed to Agent Orange have a 48 percent increased risk of prostate cancer recurrence following surgery than their unexposed peers , and when the disease comes back, it seems more aggressive, researchers say.

"We need to be screening these patients earlier, treating their cancer aggressively and following them closely afterward because they are at higher risk for recurrence," says Dr. Martha Terris, chief of the Urology Department at the Augusta Veterans Affairs Medical Center and professor of urology at the Medical College of Georgia.

"We looked at all patients, whether they were exposed or not, to see which were more likely to develop a recurrence and patients with a history of Agent Orange exposure were more likely," says Dr. Sagar R. Shah, MCG urology resident who is presenting the data May 20 during the American Urological Association Annual Meeting in Anaheim, Calif.

The study looked at 1,653 veterans who had prostate cancer surgery at Department of Veterans Affairs Medical Centers in five cities between 1990 and 2006; 199 had been exposed to Agent Orange, a herbicide and defoliant sprayed on the dense forests of Vietnam during the war.

Agent Orange contains the carcinogen, dioxin, which can be stored in body fat and is believed to make its way into the cell nucleus and work as a tumor promoter. In the past, relatively higher mortality rates have been found in chemical plant workers and farmers with prostate cancer who were exposed to dioxin, the researchers write in their abstract.

Dioxins impact is dose-related, and while the researchers did not measure levels of dioxin or Agent Orange, they suspect that blacks, who were more likely to be ground troops, also were more likely to have had more Agent Orange exposure.

Researchers found veterans with Agent Orange exposure more likely to be black and younger at the time of surgery to remove their prostate gland. The disea se appeared to be caught earlier in exposed veterans. Most had their disease staged as T1 by pathologists, which means it appeared confined to the prostate gland, and had lower pre-operative prostate specific antigen scores, an indicator of disease aggressiveness.

However, when the disease recurred, exposed veterans experienced a more rapid biochemical progression of their disease, which PSA measures. In blacks, the PSA doubled in almost half the time of their unexposed peers.

A blood PSA level screens for prostate cancer for most men beginning at age 50 and at age 40 for blacks and men with a family history. Black men have been shown by Dr. Terris and others to have more aggressive disease earlier in life.

To account for known racial differences, researchers also compared recurrence rates in exposed and non-exposed blacks and whites and the results held up.

"As a population in general, if you were exposed to Agent Orange, youre more likely to have a recurrence," says Dr. Shah. "If you were black and exposed, you were more likely to recur than if you were black and unexposed."

If it sounds odd that men who had their prostate removed could have disease recurrence, Dr. Terris points out that microscopic cancer cells can migrate out of the area before surgery, becoming detectable later when they start pushing PSA levels back up.

In fact, following any type of prostate cancer treatment, men routinely get PSA levels checked for the rest of their lives. Without cancer recurrence, they should stay at zero.


Related medicine news :

1. Military Veterans Suffer From Increased Risk of Heart Diseases
2. American War Veterans Not Receiving Enough Care For PTSD
3. Veterans To Get Improved Access To GP Care
4. Gulf War Veterans Exhibit Memory Impairment
5. Gulf War Veterans Exhibit Memory Impairment
6. Moves To Improve War Veterans Health Taken
7. Activists Urge Greater Medical Support for Gulf War Veterans Exposed to Sarin Gas
8. HIV Positive Men in Singapore Exposed
9. Kate Moss Glad her Drug Addiction was Exposed
10. Australian Children Not Being Exposed To Enough Sunlight
11. Lakhs of Indians Exposed to High Levels of Poisonous Gases
Post Your Comments:

(Date:11/27/2015)... ... November 27, 2015 , ... The moment you stop ... not only fulfilling the needs of advisers and clients but going above and ... providing top-tier customer service. However, there's always room for improvement, which is why ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... successful and prominent nonprofit healthcare organizations in the country. They have overseen financial ... organizations, and helped advance the healthcare industry as a whole through their advocacy ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... Q-Suite, announces the incorporation of Asterisk 11 LTS (Long Term Support) into its ... 11 LTS brings Q-Suite 5.10 up-to-date with a version of Asterisk that will ...
(Date:11/26/2015)... ... November 26, 2015 , ... CognisantMD and Cambridge Memorial ... in the Waterloo region. Using the Ocean Platform, family physicians can now order ... electronic medical record (EMR) without the need for redundant patient entry or an ...
(Date:11/26/2015)... ... ... Jobs in hospital medical laboratories and in the imaging field lead the ... Aureus Medical Group . These fields, as well as travel nursing, ranked ... jobs through the company’s website, , The leading healthcare staffing agency ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 ... Juntendo universitetssjukhus ser potential att använda ... magnetresonansbilder (MR-bilder) för patienter med multipel ... ett forskningsavtal med SyntheticMR AB för att ... forskningsprojekt på sjukhuset. Med SyMRI kan man ...
(Date:11/26/2015)... Nov. 26, 2015 Research and Markets ... the "2016 Future Horizons and Growth Strategies ... Supplier Shares, Country Segment Forecasts, Competitive Intelligence, Emerging ... --> --> This ... the Italian therapeutic drug monitoring market, including emerging ...
(Date:11/25/2015)... , Nov. 25, 2015  Amgen (NASDAQ: AMGN ... Application (BLA) with the United States ... 501, a biosimilar candidate to Humira ® (adalimumab). ... application submitted to the FDA and represents Amgen,s first ... Sean E. Harper , M.D., executive vice president of ...
Breaking Medicine Technology: