Navigation Links
Very Soon You can Eat to Your Hearts Content

After 20 weeks on the diets, the mice that had the active ACAT2 enzyme and were fed saturated fat and both types of monounsaturated fat had higher levels of cholesterol and more atherosclerosis than the mice that were fed polyunsaturated fats.

All of the mice without the ACAT2 enzyme were protected against atherosclerosis, which is the buildup of fatty deposits in the blood vessels that can lead to heart attacks and strokes.

"Regardless of the diet fed, the mice without ACAT2 were protected from atherosclerosis," said Rudel.

Eliminating ACAT2 did not interfere with the normal processing of cholesterol. ACAT2 is one of three enzymes that can change cholesterol into a form that can be more easily carried in blood. Studies in both mice and monkeys show that when cholesterol is altered by ACAT2, it is more likely to build up in blood vessel walls and cause atherosclerosis.

Rudel hopes to get funding to repeat the study in monkeys.

"If it works in monkeys, it would be proof of concept that it could work in humans," he said.

He also hopes the research will lead to a drug that can inhibit the enzymes actions in humans. Currently, there is a compound that can block ACAT2, but it must be injected so isnt quite as practical as a drug. He is collaborating with a pharmaceutical company that is working to find a compound that could be taken orally.

Scientists already know that humans produce ACAT2 in the liver and that women have lower levels than men. Research has shown that estrogen can lower ACAT2 production, which may partly explain why women are less likely than men to get heart disease during their estrogen-producing years.

"All of these findings tell us that a potential treatment for protecting against heart disease is a compound that decreases ACAT2 activity," said Rudel.

The findings are reported online by Arteriosclerosis, Thrombosis and Va
'"/>




Page: 1 2 3

Related medicine news :

1. Vitamin E supports Female Hearts
2. Reconstituted Blood Better For Young Hearts
3. A Call To Open Up The Channel Of Goodwill To Rescue The Dying Hearts
4. Surgeons in India to Mend ‘Pakistani Hearts’ by treating 70 Childrn
5. Novel Biological Pacemaker Under Construction for Weak Hearts
6. Murder Accused Wins Hearts By Donating An Eye
7. Heart Brakes: Hearts in European Union Invite Health Attention
8. Apollos Foray into the Hearts of Women
9. Older Donor Hearts worth Its Weight in Gold
10. Stem Cells Of Little Use In Damaged Hearts
11. Rescuing Injured Hearts by Enhancing Regeneration
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Very Soon You can Eat Your Hearts Content

(Date:4/23/2014)... Moffitt Cancer Center researchers say clinical trials for ... leukemia (AML) are very promising. Patients treated with ... and daunorubicin, are showing better responses than patients ... , "Acute myeloid leukemia is an aggressive ... success, especially in older patients," explained Jeffrey Lancet, ...
(Date:4/23/2014)... O,Shea, M.D., scientific director at the National Institute of ... named the 2014 recipient of the Ross Prize in ... journal Molecular Medicine . The award will be ... of Sciences in Manhattan, followed by scientific presentations by ... of the National Institutes of Health. , The award, ...
(Date:4/23/2014)... Society for Radiation Oncology (ASTRO) has issued a ... for Endometrial Cancer: An ASTRO Evidence-Based Guideline," that ... the treatment of endometrial cancer. The guideline,s executive ... of Practical Radiation Oncology (PRO), the ... guideline is available as an open-access article online ...
(Date:4/23/2014)... - Purdue University researchers have developed a way to ... by using tiny gold particles with tails of synthetic ... agricultural and biological engineering, used gold nanoparticles to target ... BRCA1 messenger RNA splice variants, which can indicate the ... these mRNA splice variants in a cell can be ...
(Date:4/23/2014)... targets an important brain receptor has a dramatic effect ... behavior, a University at Buffalo animal study has found. ... be a novel lead compound for treating cocaine addiction, ... was published as an online preview article in ... compound, RO5263397, severely blunted a broad range of cocaine ...
Breaking Medicine News(10 mins):Health News:Moffitt Cancer Center's phase 3 study may be game-changer for acute myeloid leukemia 2Health News:NIH scientist to receive Ross Prize in Molecular Medicine 2Health News:ASTRO issues guideline on the role of postoperative radiation therapy for endometrial cancer 2Health News:ASTRO issues guideline on the role of postoperative radiation therapy for endometrial cancer 3Health News:Gold nanoparticles help target, quantify breast cancer segments in a living cell 2Health News:Novel compound halts cocaine addiction and relapse behaviors 2
... ... Flying Marijuana Bud Banner On Labor Day Weekend , ... Seattle, WA (PRWEB) September 4, 2009 -- When Labor Day crowds ... a flying marijuana bud on a massive banner along with the words "Want Big, Sugary ...
... ... Channel on the Fast Growth 100 list. The Fast Growth 100 recognizes the fastest growing ... , ... 4, 2009 -- Netelligent today announced that it has been recognized by Everything Channel on ...
... ... its short term medical insurance product to HCC Life Short Term Medical (STM). , ... Indianapolis, IN (PRWEB) September 3, 2009 ... term medical insurance product to HCC Life Short Term Medical (STM). Formerly known ...
... , , PALO ALTO, Calif., ... announced today that company management will present a corporate overview at ... Myers, President of Jazz Pharmaceuticals, will speak at the Rodman & ... 3:15 p.m. EDT at the Palace Hotel in New York City. ...
... say more research is needed , THURSDAY, Sept. 3 (HealthDay ... a new Danish study indicates they might also raise the ... and women. , That,s not to say fat thighs confer ... nearly 3,000 men and women who were followed for more ...
... , , , SAN FRANCISCO, ... will be ensuring expedited access to needed prescriptions and mental health ... California. , , "During this taxing and difficult ... people impacted by the wildfires to continue to have uninterrupted access ...
Cached Medicine News:Health News:Labor Day Beach Visitors Will See Giant Hydroponics Marijuana Bud Banner Flying Over Los Angeles & San Diego 2Health News:Labor Day Beach Visitors Will See Giant Hydroponics Marijuana Bud Banner Flying Over Los Angeles & San Diego 3Health News:Netelligent Recognized on the Everything Channel Fast Growth 100 List at #13 2Health News:Netelligent Recognized on the Everything Channel Fast Growth 100 List at #13 3Health News:HCC Life Insurance Company Renames Short Term Medical Insurance 2Health News:Thin Thighs Might Be Harbinger of Heart Disease 2Health News:Blue Shield of California Streamlines Access to Benefits and Prescriptions for Wildfire Victims 2
(Date:1/15/2014)...  Novation, the leading health care supply chain expertise, analytics ... (VAR) national contracts that expand its portfolio to provide ... costs. These include manufacturer product and service agreements, as ... ongoing IT consulting support. New Novation ...
(Date:1/15/2014)... Calif. , Jan. 15, 2014 Massachusetts ... (NASDAQ: AMGN ) announced today that ... discover and validate new therapeutic targets and develop ... chronic disorder that affects millions worldwide. The MGH-Broad-Amgen ...
(Date:1/15/2014)... 15, 2014  Humberto C. Antunes,  Galderma  worldwide CEO, will ... Journal of Drugs in Dermatology (JDD) at ... The event is January 17-20, 2014, at the Omni Orlando Resort ... The ODAC is a distinguished event that ...
Breaking Medicine Technology:New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 2Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 4
... , June 2 Today, the U.S. Food and Drug ... active ingredient known as a long-acting beta-agonist (LABA).  This follows the FDA ... medications to undertake class-labeling changes. , ... (Logo: http://www.newscom.com/cgi-bin/prnh/20091027/PH99766LOGO ) , ...
... , June 2 GlaxoSmithKline (NYSE: ... a letter from the U.S. Food and Drug Administration ... Serevent® and Advair®.  The letter concludes discussions between GSK ... the safety profile of long-acting beta2-agonists in the treatment ...
Cached Medicine Technology:FDA Updates U.S. Product Labels for LABA-Containing Medications Including AstraZeneca's SYMBICORT 2FDA Updates U.S. Product Labels for LABA-Containing Medications Including AstraZeneca's SYMBICORT 3FDA Updates U.S. Product Labels for LABA-Containing Medications Including AstraZeneca's SYMBICORT 4FDA Updates U.S. Product Labels for LABA-Containing Medications Including AstraZeneca's SYMBICORT 5FDA Updates U.S. Product Labels for LABA-Containing Medications Including AstraZeneca's SYMBICORT 6GSK Announces Revised Product Labels for Serevent® and Advair® 2
... Bird and Cronin, Inc. ... of Patient Footwear, Orthopedic ... Care Products. Our products ... quality and available in ...
... Model C-18 is made of ... padding. Front and back sections ... larger openings to facilitate air ... is lightweight and washable. Model ...
Ezy Wrap® Economy Contour Cervical Collar Medium-density urethane foam. Synthetic white stockinette cover. Reverses for flexion or extension. (Contact closure. Hand wash. Air dry. 10/pack.)...
... improves patient compliance, prevent skin breakdown ... user's anatomy, wicks moisture, and evenly ... shoulders and upper throacic. Fits upright ... airflow openings. Adjustable Occipital Support Strap™ ...
Medicine Products: