Navigation Links
Very Soon You can Eat to Your Hearts Content

A new study on mice has raised the hope that it might one day be possible for humans to eat what they want without having to worry about the risk of developing heart disease.

Boffins at the Wake Forest University Baptist Medical Center have successfully deleted a gene in the mice that causes production of ACAT2, an enzyme that alters the molecular structure of cholesterol so that it can be transported to the bodys cells.

Lawrence Rudel, Ph.D., a professor of comparative medicine, said that the study raised hope for humans.

"We deleted an enzyme in mice and they could eat any type of fat and not get heart disease. If youre a mouse, its great. Of course, we dont know yet if it will be the same in humans," he said.

"Regardless of the type of fatty acid in the diet, even trans fat, no atherosclerosis occurs if the ACAT2 enzyme isnt present. Our research in animals tells us that ACAT2 is a potential treatment target to protect people against heart disease," he added.

As a part of the study groups of female mice with and without the ACAT2 gene were fed six different diets enriched with one of these types of fat: fish oil, flax seed oil, polyunsaturated fat from vegetable oil, saturated fat, trans-monounsaturated fat and cis-monounsaturated fat, such as in olive oil.

Fish oil, flax seed oil and polyunsaturated fats are considered "healthy" fats. Saturated fat found in meats, milk and cheeses, coconut oil, palm oil and palm kernel oil is considered a main cause of high cholesterol.

There are two types of monounsaturated fatty acids, "cis" and "trans," which are named according to their shapes. Trans-fatty acids are formed when vegetable oil is treated to make it less likely to go rancid and are found in many fried foods, baked goods and potato chips.

Cis monounsaturated fat is naturally occurring and is particularly high in canola and olive oil.

After 20 weeks on the diets, the mice that had the active ACAT2 enzyme and were fed saturated fat and both types of monounsaturated fat had higher levels of cholesterol and more atherosclerosis than the mice that were fed polyunsaturated fats.

All of the mice without the ACAT2 enzyme were protected against atherosclerosis, which is the buildup of fatty deposits in the blood vessels that can lead to heart attacks and strokes.

"Regardless of the diet fed, the mice without ACAT2 were protected from atherosclerosis," said Rudel.

Eliminating ACAT2 did not interfere with the normal processing of cholesterol. ACAT2 is one of three enzymes that can change cholesterol into a form that can be more easily carried in blood. Studies in both mice and monkeys show that when cholesterol is altered by ACAT2, it is more likely to build up in blood vessel walls and cause atherosclerosis.

Rudel hopes to get funding to repeat the study in monkeys.

"If it works in monkeys, it would be proof of concept that it could work in humans," he said.

He also hopes the research will lead to a drug that can inhibit the enzymes actions in humans. Currently, there is a compound that can block ACAT2, but it must be injected so isnt quite as practical as a drug. He is collaborating with a pharmaceutical company that is working to find a compound that could be taken orally.

Scientists already know that humans produce ACAT2 in the liver and that women have lower levels than men. Research has shown that estrogen can lower ACAT2 production, which may partly explain why women are less likely than men to get heart disease during their estrogen-producing years.

"All of these findings tell us that a potential treatment for protecting against heart disease is a compound that decreases ACAT2 activity," said Rudel.

The findings are reported online by Arteriosclerosis, Thrombosis and Va scular Biology and will appear in a future print issue.


'"/>




Related medicine news :

1. Vitamin E supports Female Hearts
2. Reconstituted Blood Better For Young Hearts
3. A Call To Open Up The Channel Of Goodwill To Rescue The Dying Hearts
4. Surgeons in India to Mend ‘Pakistani Hearts’ by treating 70 Childrn
5. Novel Biological Pacemaker Under Construction for Weak Hearts
6. Murder Accused Wins Hearts By Donating An Eye
7. Heart Brakes: Hearts in European Union Invite Health Attention
8. Apollos Foray into the Hearts of Women
9. Older Donor Hearts worth Its Weight in Gold
10. Stem Cells Of Little Use In Damaged Hearts
11. Rescuing Injured Hearts by Enhancing Regeneration
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... that was developed to enhance the health of felines. The formula is all-natural and ... main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are ...
(Date:6/25/2016)... TX (PRWEB) , ... June 25, 2016 , ... Austin ... of the American College of Mohs Surgery and to Dr. Russell Peckham for medical ... and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe ... from the David Geffen School of Medicine at UCLA. He trained in Internal Medicine ... his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... A recent ... that most people are unfamiliar with. The article goes on to state that individuals ... also many of these less common operations such as calf and cheek reduction. The ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Dublin - ... " Global Markets for Spectroscopy Equipment" report ... This report focuses on the global market of ... applications in various applications. The report deals with spectroscopy ... industries: pharmaceutical and biotechnology, food and beverage, and environmental ...
(Date:6/24/2016)... Research and Markets has announced the ... Tests" report to their offering. ... The World Market for Companion Diagnostics covers the ... analysis in the report includes the following: ... Kits) by Region (N. America, EU, ROW), 2015-2020 , ...
(Date:6/23/2016)... HOUSTON , June 23, 2016  MedSource ... platform as its e-clinical software solution of choice.  ... the best possible value to their clients by ... nowEDC.  The preferred relationship establishes nowEDC as the ... pricing for MedSource,s full-service clients.  "nowEDC has long ...
Breaking Medicine Technology: