Navigation Links
Varied Applications of Adult Stem Cells to Treat Host of Disorders in Human

The University of Pennsylvania School of Medicine has isolated a new source of adult stem cells, which have the potential to differentiate into several cell types.// If the cells show no allergic reactions in human and animal studies and are grown in increased magnitude, then it is possible to meet the needs of an individual to treat a host of disorders that includes peripheral nerve disease, Parkinson's disease, and spinal cord injury.

"We are very excited about this new source of adult stem cells that has the potential for a variety of applications," says senior author Xiaowei (George) Xu, MD, PhD, Assistant Professor of Pathology. "A number of reports have pointed to the fact that adult stem cells may be more flexible in what they become than previously thought, so we decided to look in the hair follicle bulge, a niche for these cells." Xu and colleagues report their findings in the latest issue of the American Journal of Pathology.

Hair follicles are well known to be a source for adult stem cells. Using human embryonic stem cell culture conditions, the researchers isolated and grew a new type of multipotent adult stem cell from scalp tissue obtained from the National Institute of Health's Cooperative Human Tissue Network.

The mutipotent stem cells grow as masses the investigators call hair spheres. After growing the "raw" cells from the hair spheres in different types of growth factors, the investigators were able to differentiate the stem cells into multiple lineages, including nerve cells, smooth muscle cells, and melanocytes (skin pigment cells).

The differentiated cells acquired lineage-specific markers and demonstrated appropriate functions in tissue culture, according to each cell type. For example, after 14 days, 20% to 40% of the cells in the melanocyte media took on a weblike shape typical of melanocytes. The new cells also expressed biomarkers typical of pigment cells and when placed in an artificial hum an skin construct, produced melanin and responded to chemical cues from normal epidermis skin cells.

After 14 days, about 10% of the stem cells in the neuronal cell line -- a type of cell not present in skin or hair -- grew dendrites, the long extensions typical of nerve cells and expressed neuronal proteins. The neurotransmitter glutamate was also present in the cells, but the neurotransmitter dopamine was not detected.

Thirdly, about 80% of the stem cells grown in the muscle media differentiated into smooth muscle cells. These new muscle cells also contracted when placed in a collagen matrix.

Overall, the researchers showed that human embryonic stem cell media could be used to isolate and expand a novel population of multipotent adult stem cells from human hair follicles. "Although we are just at the start of this research, our findings suggest that human hair follicles may provide an accessible, individualized source of stem cells," says Xu. The researchers are now working on inducing other cell types from the hair sphere cells and testing the cells in animal models. Study co-authors are Hong Yu, Suresh M. Kumar, and Geza Acs, all from Penn; and Dong Fang, Ling Li, Thiennga K. Nguyen, and Meenhard Herlyn, all from the Wistar Institute, Philadelphia.

(Source: Eurekalert)
'"/>




Related medicine news :

1. Adult and Children Have Varied Drug Metabolism
2. New Therapy for Lipid Disorder Demonstrates Varied Results
3. Baby Talk Better Than Adult Speech
4. A question on study of Adult Stem Cell
5. Adult COPD or asthma could be effectively treated with Xopenex
6. Adult stem cells in treatment for Multiple sclerosis (MS)
7. The Key To Prevention Of Heart Disease In Adults
8. The Harmful Effects Of Stress in Young Adults
9. Abuse in Childhood Could Result In Heart Disease in Adulthood
10. Adult bone health is dependent on lifestyle we live
11. Adult Stem Cells From Fat Tissues For Healing
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/27/2016)... Columbia, SC (PRWEB) , ... May 27, 2016 , ... ... launched a line of classic American timber frame barn kits, which can be found ... are inspired by historic American barn plans, and they highlight the craftsmanship of ...
(Date:5/27/2016)... ... May 27, 2016 , ... With over 60 percent of acute ... for a sustainable product to aid in the rehabilitation process has steadily increased. Ekso ... of individuals with hemiplegia due to stroke. , Ekso Bionics has now received clearance ...
(Date:5/27/2016)... ... ... Beleza Medspa has initiated a new program to assist active duty ... that Coolsculpting is being used for for more than just cosmetic purposes. ... prescribed body-fat standard, measured by the circumference-based tape method. The tape-test is used ...
(Date:5/27/2016)... ... May 27, 2016 , ... With a team ... and food industries. Aside from its GMP accreditation, Validation Center is also a ... certified products, services and staff. , Validation Center is ISO17025 accredited and only ...
(Date:5/26/2016)... ... May 26, 2016 , ... Cabot Corporation, ... defective respirators, according to court documents and SEC filings. A jury has ... Tyler v. American Optical Corporation, Case No. BC588866, Los Angeles County, California. The ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... 2016 According to market research ... and Demand Forecast to 2022 - Industry Insights by ... published by P&S Market Research, the global insulin delivery ... and it is expected to grow at a CAGR ... pump segment is expected to witness the fastest growth ...
(Date:5/25/2016)... May 25, 2016  Granger Diagnostics today announced immediate ... wounds and infections. This test ensures discovery of ... viruses. The test requires only a simple swab of ... David G. Bostwick , MD, Chief Medical ... wound healing: "We are excited to make available, ...
(Date:5/25/2016)... May 25, 2016 MedDay, a biotechnology ... that an oral presentation entitled "High doses of biotin in ... will be given by Professor Ayman Tourbah , Principal ... of the European Academy of Neurology (EAN) in ... disorders 3" will take place on Sunday, 29 May 2016 ...
Breaking Medicine Technology: