Navigation Links
Varied Applications of Adult Stem Cells to Treat Host of Disorders in Human

The University of Pennsylvania School of Medicine has isolated a new source of adult stem cells, which have the potential to differentiate into several cell types.// If the cells show no allergic reactions in human and animal studies and are grown in increased magnitude, then it is possible to meet the needs of an individual to treat a host of disorders that includes peripheral nerve disease, Parkinson's disease, and spinal cord injury.

"We are very excited about this new source of adult stem cells that has the potential for a variety of applications," says senior author Xiaowei (George) Xu, MD, PhD, Assistant Professor of Pathology. "A number of reports have pointed to the fact that adult stem cells may be more flexible in what they become than previously thought, so we decided to look in the hair follicle bulge, a niche for these cells." Xu and colleagues report their findings in the latest issue of the American Journal of Pathology.

Hair follicles are well known to be a source for adult stem cells. Using human embryonic stem cell culture conditions, the researchers isolated and grew a new type of multipotent adult stem cell from scalp tissue obtained from the National Institute of Health's Cooperative Human Tissue Network.

The mutipotent stem cells grow as masses the investigators call hair spheres. After growing the "raw" cells from the hair spheres in different types of growth factors, the investigators were able to differentiate the stem cells into multiple lineages, including nerve cells, smooth muscle cells, and melanocytes (skin pigment cells).

The differentiated cells acquired lineage-specific markers and demonstrated appropriate functions in tissue culture, according to each cell type. For example, after 14 days, 20% to 40% of the cells in the melanocyte media took on a weblike shape typical of melanocytes. The new cells also expressed biomarkers typical of pigment cells and when placed in an artificial hum an skin construct, produced melanin and responded to chemical cues from normal epidermis skin cells.

After 14 days, about 10% of the stem cells in the neuronal cell line -- a type of cell not present in skin or hair -- grew dendrites, the long extensions typical of nerve cells and expressed neuronal proteins. The neurotransmitter glutamate was also present in the cells, but the neurotransmitter dopamine was not detected.

Thirdly, about 80% of the stem cells grown in the muscle media differentiated into smooth muscle cells. These new muscle cells also contracted when placed in a collagen matrix.

Overall, the researchers showed that human embryonic stem cell media could be used to isolate and expand a novel population of multipotent adult stem cells from human hair follicles. "Although we are just at the start of this research, our findings suggest that human hair follicles may provide an accessible, individualized source of stem cells," says Xu. The researchers are now working on inducing other cell types from the hair sphere cells and testing the cells in animal models. Study co-authors are Hong Yu, Suresh M. Kumar, and Geza Acs, all from Penn; and Dong Fang, Ling Li, Thiennga K. Nguyen, and Meenhard Herlyn, all from the Wistar Institute, Philadelphia.

(Source: Eurekalert)
'"/>




Related medicine news :

1. Adult and Children Have Varied Drug Metabolism
2. New Therapy for Lipid Disorder Demonstrates Varied Results
3. Baby Talk Better Than Adult Speech
4. A question on study of Adult Stem Cell
5. Adult COPD or asthma could be effectively treated with Xopenex
6. Adult stem cells in treatment for Multiple sclerosis (MS)
7. The Key To Prevention Of Heart Disease In Adults
8. The Harmful Effects Of Stress in Young Adults
9. Abuse in Childhood Could Result In Heart Disease in Adulthood
10. Adult bone health is dependent on lifestyle we live
11. Adult Stem Cells From Fat Tissues For Healing
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/10/2016)... ... February 10, 2016 , ... Western University ... health services to the developmentally disabled in the Coachella Valley. , The two ... new facility at 71-949 Highway 111, Suite 100-B, in Rancho Mirage, California. The ...
(Date:2/10/2016)... ... February 10, 2016 , ... As part of its ongoing ... February 2016. Each webinar features a dynamic expert and thoughtful presentation to give ... patients and facilities. Both events are free to attend, but registration is ...
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... ... American Academy of Emergency Medicine , an emergency medicine professional association, ... practice management services . , The American Academy of Emergency Medicine, or AAEM, ...
(Date:2/10/2016)... ... 2016 , ... The Wickman Agency in Garland, TX has ... community. Pledging to select a new beneficiary every 60 days, the agency will ... is to bring community awareness to important local causes by forming campaigns which ...
(Date:2/10/2016)... ... February 10, 2016 , ... 10 Best Water ... were three leading bottled water brand owners that topped the list as a result ... and optimize conversion. The premier brand was Tibet 5100, a top notch water company ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... Mylan N.V. (NASDAQ, TASE: MYL) today announced ... December 31, 2015. --> --> ... revenues of $9.45 billion, up 28% on a constant ... of $9.43 billion. Excluding the impact of the acquisition ... generics business (the "EPD Business"), full year adjusted total ...
(Date:2/10/2016)... , Feb. 10, 2016  Resolve Therapeutics, LLC, ... new approaches to the treatment of lupus and ... a multiple ascending dose study in patients with ... RSLV-132. --> --> ... multiple ascending dose study of RSLV-132 in 32 ...
(Date:2/10/2016)... , Feb. 10, 2016  Rich Pharmaceuticals, Inc. (OTC ... a 1-for-100 reverse split of its issued and outstanding ... trading on Thursday, February 11, 2016. The Company,s common ... CUSIP number 76303T308 and temporary ticker symbol "RCHAD". After ... under the ticker symbol (RCHA).  --> ...
Breaking Medicine Technology: