Navigation Links
Variation in Genes Related to Inflammation Increase Lung Cancer Risk

Boffins have found that a variation in two genes related to inflammation, might increase risk for developing lung cancer .

The study was conducted by a team of researchers led by Eric Engels at the National Cancer Institute and the University of Texas M. D. Anderson Cancer Center.

As part of the study, researchers compared differences in genes related to inflammation between more than 1,500 lung cancer patients and 1,700 controls to examine the relationship between inflammation and lung cancer risk.

More than 80 percent of the cancer patients in the study were current or former smokers.

Researchers found that among the 59 variations in 37 inflammation-related genes studied some variants in the genes for interleukin (IL) 1A and 1B were found frequently in patients with lung cancer and especially among heavy smokers.

The genes strong effect on heavy smokers suggested that the inflammatory response is important in modulating the damage caused by tobacco smoke.

The effect was most profound in polymorphisms in IL1B, which was central to the inflammation process.

The researchers noted that the IL1B protein was an integral part of the chemical cascade by which cell signals moderate the response to inflammation.

Variations in the gene might lead to greater expression of the protein, which is more likely to turn on the cascade and sustain the damaging effects of inflammation. Over time, the constant damage of inflammation could lead to genetic damage and cancer.

Inflammation is part of the immune systems arsenal to combat the effects of infection and cell damage. However, prolonged or intense inflammation could lead to conditions within the lung environment that foster cancer, Engels said.

The findings of the study were published in the July issue of Cancer Research, a publication of the American Association for Cancer Research.


Related medicine news :

1. Variation in breast cancer
2. Risk Of Schizophrenia due to Gene Variation
3. Variations In ingredients From Brand to Brand
4. Gene Variation Associated With Better Mobility For Older Individuals
5. Tamoxifen Ineffective In Presence Of Genetic Variation in Breast Cancer
6. Seasonal Variation In Exercise And Eating Habits Identified
7. Genetic Variation In Bitter-Taste Receptor Gene Increases Alcoholic Risk
8. Gene Variations Raise the Risk of Childhood Cancer Survivors
9. Genetic Variations In Detoxifying Genes Lead To Lou Gehrigs diseases
10. Food Costs At Hospitals Show Mystifying Variations
11. Genetic Variation Linked to Age-Related Macular Degeneration
Post Your Comments:

(Date:11/27/2015)... ... November 27, 2015 , ... Keeping in mind ... mental health and wellness consultation, has collaborated with a leading web-based marketplace for ... gap experienced by parents and bring advice from parenting experts within their reach. ...
(Date:11/27/2015)... , ... November 27, 2015 , ... ... largest, most successful and prominent nonprofit healthcare organizations in the country. They have ... with various organizations, and helped advance the healthcare industry as a whole through ...
(Date:11/27/2015)... ... 27, 2015 , ... Avid collector, Andrew Hawley from Vintage Rock Posters, announces ... This is one of Joplin's most famous and beautiful concert posters. The concert was ... in Ann Arbor. The According to Hawley, "It is hard to believe that Joplin's ...
(Date:11/26/2015)... Marne, MI (PRWEB) , ... November 26, 2015 ... ... center for substance abuse located in central Michigan, have come together on Thanksgiving ... a specially produced video, available for viewing on the Serenity Point YouTube channel, ...
(Date:11/26/2015)... ... November 26, 2015 , ... CognisantMD and Cambridge Memorial ... in the Waterloo region. Using the Ocean Platform, family physicians can now order ... electronic medical record (EMR) without the need for redundant patient entry or an ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 26, 2015 ... of the  "2016 Future Horizons and ... Surface Marker Testing Market: Supplier Shares, ... their offering.  --> ... the  "2016 Future Horizons and Growth ...
(Date:11/25/2015)... WASHINGTON , Nov. 25, 2015  The ... Obstetricians and Gynecologists (ACOG), and the March of ... bipartisan Protecting Our Infants Act of 2015 ... the number of newborns born exposed to drugs, ... Since the bill,s introduction, all three organizations have ...
(Date:11/25/2015)... 25, 2015  ARKRAY USA , ... provide evidence demonstrating the accuracy of its blood glucose ... Insulin Resistance, Diabetes and Cardiovascular Disease in ... Company,s GLUCOCARD ® 01 meter and the Assure ... The ability to accurately measure glucose levels in blood ...
Breaking Medicine Technology: