Navigation Links
Variation in Genes Related to Inflammation Increase Lung Cancer Risk

Boffins have found that a variation in two genes related to inflammation, might increase risk for developing lung cancer .

The study was conducted by a team of researchers led by Eric Engels at the National Cancer Institute and the University of Texas M. D. Anderson Cancer Center.

As part of the study, researchers compared differences in genes related to inflammation between more than 1,500 lung cancer patients and 1,700 controls to examine the relationship between inflammation and lung cancer risk.

More than 80 percent of the cancer patients in the study were current or former smokers.

Researchers found that among the 59 variations in 37 inflammation-related genes studied some variants in the genes for interleukin (IL) 1A and 1B were found frequently in patients with lung cancer and especially among heavy smokers.

The genes strong effect on heavy smokers suggested that the inflammatory response is important in modulating the damage caused by tobacco smoke.

The effect was most profound in polymorphisms in IL1B, which was central to the inflammation process.

The researchers noted that the IL1B protein was an integral part of the chemical cascade by which cell signals moderate the response to inflammation.

Variations in the gene might lead to greater expression of the protein, which is more likely to turn on the cascade and sustain the damaging effects of inflammation. Over time, the constant damage of inflammation could lead to genetic damage and cancer.

Inflammation is part of the immune systems arsenal to combat the effects of infection and cell damage. However, prolonged or intense inflammation could lead to conditions within the lung environment that foster cancer, Engels said.

The findings of the study were published in the July issue of Cancer Research, a publication of the American Association for Cancer Research.


'"/>




Related medicine news :

1. Variation in breast cancer
2. Risk Of Schizophrenia due to Gene Variation
3. Variations In ingredients From Brand to Brand
4. Gene Variation Associated With Better Mobility For Older Individuals
5. Tamoxifen Ineffective In Presence Of Genetic Variation in Breast Cancer
6. Seasonal Variation In Exercise And Eating Habits Identified
7. Genetic Variation In Bitter-Taste Receptor Gene Increases Alcoholic Risk
8. Gene Variations Raise the Risk of Childhood Cancer Survivors
9. Genetic Variations In Detoxifying Genes Lead To Lou Gehrigs diseases
10. Food Costs At Hospitals Show Mystifying Variations
11. Genetic Variation Linked to Age-Related Macular Degeneration
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/8/2016)... ... February 08, 2016 , ... Delta Dental of California and its ... cancer. , Gary D. Radine, who recently retired as president and CEO of Delta ... 2015 CEO of the Year , helped lead the effort to raise funds ...
(Date:2/8/2016)... ... February 08, 2016 , ... Eating ... a significant number of women and men with eating disorders report a history ... best predicts the development of an eating disorder. , At the 2016 ...
(Date:2/8/2016)... ... February 08, 2016 , ... GrassrootsHealth published data from ... type 2 diabetes in the GrassrootsHealth cohort with substantially higher vitamin D levels ... in public health,” states Carole Baggerly, Director of GrassrootsHealth, “the safety and ...
(Date:2/8/2016)... ... February 08, 2016 , ... Joshua Rosenthal, PhD, Chief Scientific ... can use newly released government data on populations and physicians to better calculate ... capture the value they create to succeed in new economic models for value ...
(Date:2/8/2016)... , ... February 08, 2016 , ... ... only four states in the U.S. require dental technicians to be certified or ... the dental industry, NADL created the “What’s In Your Mouth?” campaign to inform ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... , Feb. 8, 2016  Echo Therapeutics, ... device company focused on non-invasive continuous glucose ... today announced that it will host a ... 17, 2015 at 9:00 a.m. Eastern Time ... its corporate strategy, advancements in its CGM ...
(Date:2/8/2016)... , Feb. 8, 2016 ... the "Global Skin Protective Equipment Market 2016-2020" ... --> http://www.researchandmarkets.com/research/fqx6nz/global_skin ) has announced the addition ... 2016-2020" report to their offering. ... ) has announced the addition of the ...
(Date:2/8/2016)... , Feb. 8, 2016   HighPoint ... November Research Group (NRG),s pharmacovigilance technology services division.  ... consulting services and an Oracle Argus Specialized partner, ... to Life Sciences companies. --> ... expands HighPoint,s life sciences capabilities and provides a ...
Breaking Medicine Technology: