Navigation Links
Variation in Genes Related to Inflammation Increase Lung Cancer Risk

Boffins have found that a variation in two genes related to inflammation, might increase risk for developing lung cancer .

The study was conducted by a team of researchers led by Eric Engels at the National Cancer Institute and the University of Texas M. D. Anderson Cancer Center.

As part of the study, researchers compared differences in genes related to inflammation between more than 1,500 lung cancer patients and 1,700 controls to examine the relationship between inflammation and lung cancer risk.

More than 80 percent of the cancer patients in the study were current or former smokers.

Researchers found that among the 59 variations in 37 inflammation-related genes studied some variants in the genes for interleukin (IL) 1A and 1B were found frequently in patients with lung cancer and especially among heavy smokers.

The genes strong effect on heavy smokers suggested that the inflammatory response is important in modulating the damage caused by tobacco smoke.

The effect was most profound in polymorphisms in IL1B, which was central to the inflammation process.

The researchers noted that the IL1B protein was an integral part of the chemical cascade by which cell signals moderate the response to inflammation.

Variations in the gene might lead to greater expression of the protein, which is more likely to turn on the cascade and sustain the damaging effects of inflammation. Over time, the constant damage of inflammation could lead to genetic damage and cancer.

Inflammation is part of the immune systems arsenal to combat the effects of infection and cell damage. However, prolonged or intense inflammation could lead to conditions within the lung environment that foster cancer, Engels said.

The findings of the study were published in the July issue of Cancer Research, a publication of the American Association for Cancer Research.


Related medicine news :

1. Variation in breast cancer
2. Risk Of Schizophrenia due to Gene Variation
3. Variations In ingredients From Brand to Brand
4. Gene Variation Associated With Better Mobility For Older Individuals
5. Tamoxifen Ineffective In Presence Of Genetic Variation in Breast Cancer
6. Seasonal Variation In Exercise And Eating Habits Identified
7. Genetic Variation In Bitter-Taste Receptor Gene Increases Alcoholic Risk
8. Gene Variations Raise the Risk of Childhood Cancer Survivors
9. Genetic Variations In Detoxifying Genes Lead To Lou Gehrigs diseases
10. Food Costs At Hospitals Show Mystifying Variations
11. Genetic Variation Linked to Age-Related Macular Degeneration
Post Your Comments:

(Date:6/25/2016)... ... 2016 , ... Experts from the American Institutes for Research ... June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR experts ... planning, healthcare costs and patient and family engagement. , AIR researchers will be ...
(Date:6/25/2016)... Aliso Viejo, California (PRWEB) , ... June 25, 2016 , ... ... preset to fit their specific project," said Christina Austin - CEO of Pixel Film ... all fully customizable and all within Final Cut Pro X . Simply select ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson ... Recently, he has implemented orthobiologic procedures as a method for treating his patients. ... the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June ... with. The article goes on to state that individuals are now more comfortable seeking ... common operations such as calf and cheek reduction. The Los Angeles area medical group, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, ... at his family verbally and physically. , “When something upset him, he couldn’t control his ... it. He would throw rocks at my other children and say he was going to ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
(Date:6/24/2016)... 24, 2016  Arkis BioSciences, a leading innovator ... more durable cerebrospinal fluid treatments, today announced it ... funding is led by Innova Memphis, followed by ... private investors.  Arkis, new financing will accelerate the ... market release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... Any dentist who has made an implant supported ... Many of them do not even offer this as a ... laboratory costs involved. And those who ARE able to offer ... high cost that the majority of today,s patients would not ... Zadeh , founder of Dental Evolutions Inc. and inventor of ...
Breaking Medicine Technology: