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Vanderbilt Performs State's First Stem Cell Heart Regeneration Therapy

Vanderbilt University Medical Center is the first in the state to perform a novel therapy that uses bone marrow stem cells to stimulate regeneration of the heart muscle after a// heart attack.

Vanderbilt is one of three medical centers in the country providing this new treatment modality as part of a multi-center, randomized study funded by Amorcyte, a privately funded cell-therapy company studying stem cells for the treatment of cardiovascular disease.

Physicians are excited about the prospects of this therapy because of the enormous potential to “transform the way we treat people with cardiac disease,” said Douglas Vaughan, M.D., chief of the Division of Cardiovascular Medicine. “This is the first patient of many that we will enroll in our randomized-controlled trials to study the effects of cell therapy in treating cardiac disease.

“It is truly gratifying that we have reached this point.”

John Plummer, 63, underwent the stem cell regeneration therapy on March 11, about one week after experiencing a heart attack.

“There are no guarantees,” said Plummer. “It was the prospect of improvement — any improvement — that made it worth it. There are certain risks, but the prospect of the study proving to be valuable to others as well, all of those considerations made it seem like something I ought to do.

“I look at it this way. This is an improvement you would give almost anything to make. There is nothing more important than your general health.”

Plummer, an English professor for 36 years at Vanderbilt University, is not the first patient tested for eligibility into the trial. More than 100 patients have been screened, but did not meet the criteria for study participation – impaired heart function after an acute heart attack.

“If we treat a patient rapidly, some may not have any damage at all,” said David Zhao, M.D., director of the Cardiac Cath Lab. “But for those who, despit e all efforts, suffer damage to the heart muscle, we are studying the effects of this treatment in repairing the heart muscle.

“We are hoping that this is just the beginning of the journey and eventually we will be able to provide this unique therapy as part of our treatment protocol to patients with a damaged heart.”

For decades, the major barrier in treating heart attack patients is the inability to repair the damaged muscle. About 20 percent of patients experience permanent muscle loss, which ultimately leads to heart failure. Heart disease is the leading cause of death in the United States. Five million people suffer from heart failure. Half of those die.

“If you look at the big picture, we don’t have a definitive way to improve people’s heart function, “said Scott Phillips, M.D., a cardiology fellow. “Heart failure has a huge financial impact on our medical system. If we could improve heart function, if this proves to be a viable therapy, there would be tremendous benefits, not only for the patient, but in terms of the amount of money a health care system could save. It would be astronomical.”

Vanderbilt’s participation in this Phase I, industry-supported study highlights its role as a key player in stem cell regeneration in this country. For years, Europe has been the site for much of the heart-related, stem cell based therapies.

“Fewer than five centers in the country are doing this kind of cell-based therapy,” said Zhao. “Coupled with the fact that we are one of five programs funded by the NIH for cell-based therapies definitely brings Vanderbilt to the next level. We are playing a leading role in cell therapy.”

Patients enrolled in the Amorcyte trial, like Plummer, will be seen regularly for up to five years. Within three to six months, investigators expect to see some improvement in heart function.

“This treatment approach looks very promising based on preliminary results a lready published,” said Friedrich Schuening, M.D., chief of the Section of Hematology and Stem Cell Transplant. “The study would not have been possible without the excellent collaboration between our colleagues from the Division of Cardiovascular Medicine and from the Vanderbilt Stem Cell Transplant Program.

“This is truly a historical event,” said Phillips. “If this therapy works, it has the potential to affect millions of peopl.”


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