Navigation Links
Valporic Acid Blocks Latent HIV Replication

Researchers at the University of North Carolina have found that administrating Valporic acid can kill dormant HIV persistent in the infected cells. HAART (Highly Active Antiretroviral Therapy), which is administered to AIDS patients acts by blocking the virus replication and also enhances the immune system // of these patients. But HAART cannot act on the virus, which is present in the latent phase in the cells. Which leads to continuous HAART treatment to affected patients, as the virus may emerge from cells as soon as HAART treatment is stopped. Researchers have found that by co-administration of Valporic acid with HAART leads to better treatment in AIDS patients. Valporic acid, which is used treat bipolar disorders, is found to block the action of Histone Deacetylase 1 (HDAC1), which helps HIV to survive in the latent phase of infection. Valporic acid stops the action of HDAC1 enzyme and breaks the latency of the virus in latent phase.

A clinical study involving 4 HIV patients undergoing HAART therapy where administered Valporic acid for three months, twice daily and the researchers found a reduction of 75% in latent HIV infection in three of the four patients during the Valporic acid treatment. If a larger clinical study is proved of its effective treatment this drug can be used for the eradication of established HIV infection. The patient should be started early HAART treatment followed by HDAC inhibitors or both for treating the latent virus infection.

Dr Chris Gadd, of the UK's Aidsmap, which offers advice on HIV/AIDS to patients and health professionals, said: "The encouraging message from this study is that using an existing, licensed drug is a feasible, although still highly experimental approach to achieving HIV eradication from these viral reservoirs, at least partially. "The study shows that the hypothesis - that the intensification of antiretroviral therapy with a new drug, coupled with the addition of valproate, can reduce the n umbers of resting, infected cells - is feasible.

Source: The Lancet


'"/>




Related medicine news :

1. Inhibitor That Blocks Host Receptors Found To be Effective In Treating Anthrax
2. New Drug Blocks Influenza, Including Bird Flu Virus
3. Latest Weight-Loss Pill Offers Modest Results, Blocks Munchies
4. Sentry Enzyme Blocks Two Paths to Parkinson’s Diseas
5. Treating Latent Herpes With Licorice
6. New Drug Promises Hope In Multiple Drug Resistant And Latent TB Treatment
7. Detecting Latent Tuberculosis Effective With Blood Tests
8. High Rates of Latent TB Infection Found in Russian Health Workers
9. Acute Measles Supresses HIV Replication
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... , ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal ... personalized through a fitness app. The fitness app plans to fix the two major problems ... offer a one size fits all type program , They don’t eliminate all ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand ... project," said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s ... within Final Cut Pro X . Simply select a ProHand generator and drag ...
(Date:6/25/2016)... ... 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s ... setting the bar too high can result in disappointment, perhaps even self-loathing. However, those ... goal. , Research from PsychTests.com reveals that behind the tendency to ...
(Date:6/24/2016)... ... 24, 2016 , ... The Pulmonary Hypertension Association (PHA) learned ... receive two significant new grants to support its work to advance research and ... by recognizing patients, medical professionals and scientists for their work in fighting pulmonary ...
(Date:6/24/2016)... TX (PRWEB) , ... June 24, 2016 , ... People ... part in Genome magazine’s Code Talker Award, an essay contest in which patients and ... an award to be presented at the 2016 National Society of Genetic Counselors (NSGC) ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... ANDOVER, Mass. and SAN CLEMENTE, Calif. ... California -based mobile pulmonary function testing company, is now ... portable PFT devices developed by ndd Medical Technologies , Inc. ... PFT testing done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ... CA , can get any needed testing done in the ...
(Date:6/24/2016)... India , June 24, 2016 ... Needles Market by Type (Standard Pen Needles, Safety Pen ... Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, ... by MarketsandMarkets, This report studies the market for the ... expected to reach USD 2.81 Billion by 2021 from ...
(Date:6/24/2016)... Belgium , June 24, 2016 ... the appointment of Dr. Edward Futcher ... Non-Executive Director, effective June 23, 2016.Dr. Futcher was ... Nominations and Governance Committees.  As a non-executive member ... independent expertise and strategic counsel to VolitionRx in ...
Breaking Medicine Technology: