Navigation Links
Valporic Acid Blocks Latent HIV Replication

Researchers at the University of North Carolina have found that administrating Valporic acid can kill dormant HIV persistent in the infected cells. HAART (Highly Active Antiretroviral Therapy), which is administered to AIDS patients acts by blocking the virus replication and also enhances the immune system // of these patients. But HAART cannot act on the virus, which is present in the latent phase in the cells. Which leads to continuous HAART treatment to affected patients, as the virus may emerge from cells as soon as HAART treatment is stopped. Researchers have found that by co-administration of Valporic acid with HAART leads to better treatment in AIDS patients. Valporic acid, which is used treat bipolar disorders, is found to block the action of Histone Deacetylase 1 (HDAC1), which helps HIV to survive in the latent phase of infection. Valporic acid stops the action of HDAC1 enzyme and breaks the latency of the virus in latent phase.

A clinical study involving 4 HIV patients undergoing HAART therapy where administered Valporic acid for three months, twice daily and the researchers found a reduction of 75% in latent HIV infection in three of the four patients during the Valporic acid treatment. If a larger clinical study is proved of its effective treatment this drug can be used for the eradication of established HIV infection. The patient should be started early HAART treatment followed by HDAC inhibitors or both for treating the latent virus infection.

Dr Chris Gadd, of the UK's Aidsmap, which offers advice on HIV/AIDS to patients and health professionals, said: "The encouraging message from this study is that using an existing, licensed drug is a feasible, although still highly experimental approach to achieving HIV eradication from these viral reservoirs, at least partially. "The study shows that the hypothesis - that the intensification of antiretroviral therapy with a new drug, coupled with the addition of valproate, can reduce the n
'"/>




Page: 1 2

Related medicine news :

1. Inhibitor That Blocks Host Receptors Found To be Effective In Treating Anthrax
2. New Drug Blocks Influenza, Including Bird Flu Virus
3. Latest Weight-Loss Pill Offers Modest Results, Blocks Munchies
4. Sentry Enzyme Blocks Two Paths to Parkinson’s Diseas
5. Treating Latent Herpes With Licorice
6. New Drug Promises Hope In Multiple Drug Resistant And Latent TB Treatment
7. Detecting Latent Tuberculosis Effective With Blood Tests
8. High Rates of Latent TB Infection Found in Russian Health Workers
9. Acute Measles Supresses HIV Replication
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Valporic Acid Blocks Latent HIV Replication

(Date:9/16/2014)... 16, 2014 CarePoint Health is ... Leigh Montes, MD, has joined our expanded Bariatric ... Hospital. Our system welcomes Dr. Montes to the ... surgical weight loss center, helps patients achieve long-term ... surgery procedures, including Gastric Sleeve, Gastric Bypass, LAP-BAND ...
(Date:9/16/2014)... HealthDay Reporter MONDAY, Sept. 15, 2014 ... can delay a man,s onset of age-related high blood pressure ... pressure naturally increases as people grow older and their arteries ... don,t start drifting toward high blood pressure until their mid-50s. ... early signs of high blood pressure in their mid-40s, researchers ...
(Date:9/16/2014)... discoveries everyday, but that doesn,t mean the findings are ... example, the neonatal mortality rate is 10 times higher ... that applying an inexpensive topical solution of chlorhexidine to ... rate by 24 percent, many Indian parents did not ... not that we don,t have solutions to solve major ...
(Date:9/16/2014)... The Columbia University College of Dental Medicine ... in Diversity (HEED) award from INSIGHT Into Diversity ... higher education. As a recipient of the annual ... universities that demonstrate an outstanding commitment to diversity ... other recipients in INSIGHT Into Diversity magazine,s November ...
(Date:9/16/2014)... Size is relative, especially to people who tend to ... University Medical Center in the US found that seven ... weighs. People of normal weight make this mistake much ... tend to misjudge their children,s size, as youngsters misjudge ... now at Weill-Cornell Medical College, in a study in ...
Breaking Medicine News(10 mins):Health News:Top Bariatric Surgeon Joins CarePoint Health 2Health News:Top Bariatric Surgeon Joins CarePoint Health 3Health News:Blood Pressure Seems to Stay Lower Longer in Fitter Men 2Health News:Blood Pressure Seems to Stay Lower Longer in Fitter Men 3Health News:Pairing social networks with social motives to close the science gap 2Health News:Pairing social networks with social motives to close the science gap 3Health News:Columbia University College of Dental Medicine receives diversity award 2Health News:Columbia University College of Dental Medicine receives diversity award 3Health News:Columbia University College of Dental Medicine receives diversity award 4Health News:Poor body size judgement can lead to increased tolerance of obesity 2
... , MONDAY, March 21 (HealthDay News) -- A woman,s use ... risk of respiratory problems in her children, according to a ... use of birth control pills may increase the risk of ... said the authors of the new study. The researchers ...
... MONDAY, March 21 (HealthDay News) -- While the majority of ... generally satisfied years later, almost 40 percent are saddled with ... removed, a small, new Belgian study reveals. The finding ... the University of California, San Francisco that suggested gastric bypass ...
... Rockville, Md., March 21, 2011 As part of ... Pharmacopeial Convention (USP) is working with the Food and ... (CHPA) to update quality standards for widely used medicines ... an ambitious, long-term effort to assess written (or documentary) ...
... Health Sciences University is enrolling patients in a federally funded ... progression of kidney disease. "The question is, if you ... said Dr. Laura Mulloy, Chief of the GHSU Section of ... Intervention Trial, or SPRINT, funded by the National Institutes of ...
... change the balance of bacteria that naturally live in the ... Brain, Behavior, and Immunity . "These bacteria ... the immune response," said lead researcher Michael Bailey. ... number of gut microorganisms, according to scientists from The Ohio ...
... March, 2011 Alcohol use during pregnancy is common ... and development of exposed offspring. Despite warnings from the ... contemplating pregnancy, a recent survey by the National Birth ... drank alcohol at some time during their pregnancy, with ...
Cached Medicine News:Health News:Moms' Use of 'the Pill' Won't Raise Kids' Asthma Risk: Study 2Health News:40% of Gastric Banding Patients Have Complications 2Health News:40% of Gastric Banding Patients Have Complications 3Health News:40% of Gastric Banding Patients Have Complications 4Health News:Quality standards for widely used medicines strengthened 2Health News:Quality standards for widely used medicines strengthened 3Health News:Study examines whether lower blood pressure reduces kidney disease progression 2Health News:Adolescent offspring of women who drank alcohol during first trimester 2
(Date:9/16/2014)... QPID Health , a leader in clinical intelligence software, today ... and their first West Coast location in San ... in Boston , and will house product development, ... Southern California office will be located at 1000 ... demands of customers nationwide.  Both new locations will be operational ...
(Date:9/16/2014)... 16, 2014   Evana Automation Specialists , a ... and test systems, recently received a contract to provide ... manufacturer. The Evana solution will help error-proof the process ... well as reduce labor. A catheter ... robotic assembly cell. The robot will pick the adapter, ...
(Date:9/16/2014)... ORLANDO, Fla. , Sept. 16, 2014   ... standard in the patient experience at hospitals. The myComfort™ ... , Vestagen,s active barrier fabric that is fluid repellant, ... shown to inhibit the growth of bacteria on the ... the role clothing plays in the chain of transmission. ...
Breaking Medicine Technology:QPID Health Announces Major Office Expansion in Boston and Opens Facility in San Diego 2Evana Automation to Supply Robotic Assembly Cell to Leading Medical Device Manufacturer 2Evana Automation to Supply Robotic Assembly Cell to Leading Medical Device Manufacturer 3New Vestagen Patient Garments Aim to Minimize Pathogen Transmission Inside Hospitals 2
... (OTC Bulletin Board: ACUR) (the "Company") today announced ... "Agreement"), with an,investor group comprised of Vivo Ventures ... L.P., GCE Holdings LLC and certain individual investors,(the ... Units ("Units") at a price of $1.08 per ...
... 20 Ranbaxy Pharmaceuticals Inc.,(RPI), a wholly owned ... RLL has received approval from the U.S. Food ... and,Acetaminophen Tablets USP, 7.5 mg/750 mg, 10 mg/500 ... The Office of Generic Drugs, U.S. Food and ...
Cached Medicine Technology:Acura Pharmaceuticals, Inc. Secures Financing to Fund Pivotal Phase III Clinical Trial for Lead Aversion(R) Technology Product Candidate 2Acura Pharmaceuticals, Inc. Secures Financing to Fund Pivotal Phase III Clinical Trial for Lead Aversion(R) Technology Product Candidate 3Ranbaxy Receives Approval to Manufacture and Market Hydrocodone Bitartrate and Acetaminophen Tablets USP 2
... Battery Powered Orthopedic Systems., ,The PowerPro® ... to the Hall® Surgical line of powered ... the first and only software controlled battery ... is a full-function orthopedic power system specifically ...
... Brasseler USAs Large Bone Power System is ... new technological advancements. The truly innovative design ... pack, which is comprised of the battery, ... contains only mechanical components, which provides a ...
... is a type I collagen implant designed ... or loss of meniscus tissue, typically through ... purpose of the CMI is to assist ... a more vigorous lifestyle, while forestalling or ...
... OBIs proprietary PolyGraft® material technology which ... that is both biologically friendly and ... of polylactide-co-glycolide, calcium sulfate and polyglycolide ... fabricated into products such as granules, ...
Medicine Products: