Navigation Links
Valium hits 40 years old, anxiety-free

Valium, the drug that revolutionized the treatment of anxiety and became a cultural icon, is 40 years old this year.
The drug owes its success to the stubborn streak of chemist Leo Sternbach, who refused to quit after his boss at Hoffmann-La Roche ended a project to develop a tranquilizer to compete with a rival company's drug. Sternbach tested one last version and in just a day, he got the results: The compound made animals relaxed and limp.//

Sternbach had made the discovery that eventually led to Valium. It was approved for use in 1963 and became the country's most prescribed drug from 1969 to 1982. Valium also was referred to as a "doll" -- one of the pills popped by female characters in novelist Jacqueline Susann's racy 1966 best-seller "Valley of the Dolls." Most of the prescriptions were written by family doctors rather than psychiatrists, and the majority of users were women.

With Valium, Sternbach gave the company its first blockbuster. Sternbach had created an entire new class of tranquilizers named benzodiazepines, which were safer and more effective than previous treatments such as barbiturates, opiates, alcohol and herbs. Unlike earlier drugs, Valium did not slow breathing, so patients couldn't use it to commit suicide. But it was overused, Sternbach said; some patients became addicted, so a doctor's visit was required for refills.

Still, benzodiazepines remain the most prescribed anxiety drugs, partly because they start working as fast as one hour, slowing brain activity. They also are used for treating panic and phobia disorders and insomnia, calming patients before surgery and relaxing muscles. Sternbach officially retired in 1973, but worked most days until recently. He mentored young scientists, corresponded and consulted with others, and worked on his biography, due out this fall under the title, "Good Chemistry: The Life and Times of Valium Inventor Leo Sternbach." Sternbach's credits include 241 patents, 122 pu blications, honorary degrees and other awards. His other breakthroughs include the sleeping pills Dalmane and Mogadon, Klonopin for epileptic seizures and Arfonad, for limiting bleeding during brain surgery.

"He's an inventor's inventor," "Within every company, there is a person or two whose legacy becomes the hallmark of what the company is about, and for Roche, it is Dr. Sternbach."

Related medicine news :

1. Test tube babies, 25 years later
2. Diabetes cases could double in developing countries in next 30 years
3. Larynx transplant restores patients voice after 20 years
4. New Blood Thinner Pill - First Potential Alternative to Warfarin in 50 years
5. Microbicides could serve to materialise women empowerment in the years to come
6. Diagnosis of Alzheimers years before clinical signs emerge
7. Induced abortion results in years of trauma.
8. 10 Million Indian Females Aborted In 20 years
9. Loss and damage to the brain cells possible with lead exposure in years ahead
10. Womb transplantation- to be successful in 2 years’ tim
11. Babies under two years of age to be administered Meningitis vaccination
Post Your Comments:

(Date:6/27/2016)... ... June 27, 2016 , ... The ... OSHA Training Institute Education Center headquartered in Northern California, has issued an important ... heat at their worksites. Employers with workers exposed to high temperatures should ...
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal their media ... Pro X," said Christina Austin - CEO of Pixel Film Studios. , ProSlice ... X users can now reveal the media of their split screens with growing ...
(Date:6/27/2016)... ... June 27, 2016 , ... TherapySites, ... today its affiliation with Tennessee Counseling Association. This new relationship allows ... the Tennessee Counseling Association, adding exclusive benefits and promotional offers. , "TCA is ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... industry today announced its strategic partnership with Connance, a healthcare industry leader ... two companies’ proven, proprietary technology combine to provide health systems, hospitals and ...
(Date:6/27/2016)... Brooklyn, NY (PRWEB) , ... June 27, 2016 ... ... is using cutting edge technology to revolutionize the emergency ambulance transport experience for ... Many are aware of how Uber has disrupted the taxi industry through the ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... June 26, 2016 One of Australia,s ... the formation of a new biotechnology company, Noxopharm Limited [ABN 50 ... an IPO and to list on the ASX. Noxopharm ... ready to enter a Phase 1 clinical study later this year. ... address one of the biggest problems facing cancer patients - the ...
(Date:6/26/2016)... Jazz Pharmaceuticals plc (Nasdaq: JAZZ ) announced ... Act of 1976, as amended ("HSR"), with respect to ... CPXX ) expired effective June 24, 2016, ... previously announced on May 31, 2016, Jazz Pharmaceuticals and ... Jazz Pharmaceuticals has commenced a tender offer for all ...
(Date:6/26/2016)... 27, 2016  VMS Rehab Systems, Inc. ( ... whatever measures required to build a strong and stable ... currently listed on the OTC Markets-pink current trading platform. ... CEO, "We are seeing an anomaly in market trading ... only by the Company, but shareholders and market players ...
Breaking Medicine Technology: