Navigation Links
Valerian was first epilepsy drug

The herbal medicine valerian may have been the world's first epilepsy drug, an Australian neurologist says.//

Today, valerian (Valeriana officinalis) is best known as a mild sedative, taken either as a herbal infusion of the dried root or in capsule or tablet form.

But the Italian author Fabio Colonna first mentioned using valerian to control seizures in his 1592 botanical work Phytobasanos.

Colonna said he had controlled his own seizures by taking powdered valerian root several times a day.

By the late 18th and early 19th centuries valerian was often regarded in parts of Europe as the best treatment for controlling seizures.

But as other medicines were developed valerian's use as an antiepileptic drug waned, especially as it smelt and tasted awful.

"As they dry, exposed valerian roots ... develop a characteristic offensive odour resembling that of sweaty socks or dirty underwear," Eadie told ABC Science Online.

This is due to formation of isovaleric acid, believed to be valerian's active ingredient.That's why it is unlikely valerian itself will be developed into an antiepileptic drug, Eadie said.

"No one in their right mind would do a clinical trial. It is too intolerable in the doses needed."

Valerian as a modern-day medicine?

But Eadie said one drug company thinks isovaleramide, a form converted to isovaleric acid in the body, looked promising.

U.S. company NPS Pharmaceuticals has completed preliminary trials on isovaleramide. If isovaleramide works with few side-effects, it may well replace other medications, Eadie said.

"Valerian seems reasonably safe in connection with its use as a sleeping remedy," Eadie said. But he warned people with epilepsy not to experiment with valerian. Researchers did not know the active ingredient; the dose needed to control epilepsy may be many times higher than used for sedation; and doctors do n ot know if valerian can cause a bad reaction when mixed with other medicines.

Courtesy : CoABC Science Online
'"/>




Related medicine news :

1. Infant receives first bloodless liver transplant
2. Oracle Corp. to help build worlds first "Digital Hospital"
3. FDA approves first pocket-sized EKG machine
4. New device for ailing heart fitted into first patient
5. Canada helps in giving birth to world first baby from frozen egg
6. SNUPPY – Woo Suk Hwang reveals World’s first dog cloe
7. Successful creation of human embryos from a single parent for the first time
8. A first for India - IVF baby born of surrogacy
9. Age of first alcoholic drink determined by tendency to cheat
10. Evidence against use of Beta blockers as first choice in the treatment of primary hypertension
11. United Kingdom to perform its first Live Liver Transplant
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... , ... Many families have long-term insurance that covers care for a family ... for care if the client has a cognitive impairment diagnosis. , “What this ... often waived, so the benefits from their insurance start immediately,” said Mechell Vieira, owner ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Software Development, has been awarded a contract by the Center for Medicare and ... aims to accelerate the enterprise use of Agile methodologies in a consistent and ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... advisory services for healthcare compliance program management, will showcase a range of technology ... Association for Assisted Living (NCAL) Convention and Expo to be held October 14–18, ...
(Date:10/12/2017)... ... 2017 , ... The company has developed a suite of ... authorities worldwide. From Children’s to Adults 50+, every formula has been developed by ... , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, Non-Dairy*, Preservative ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... for their devotion to personalized service, SMP Pharmacy Solutions announces ... the South Florida Business Journal,s 50 Fastest-Growing Companies, and listed ... national specialty pharmacy has found its niche.  To that end, ... honored by SFBJ as the 2017 Power Leader in Health ... his award in October, Bardisa said of the three achievements, ...
(Date:9/25/2017)... 25, 2017   Montrium , an industry ... today—from the IQPC Trial Master Files & Inspection ... that EastHORN Clinical Services has selected eTMF ... TMF management. EastHORN, a leading European contract research ... increase transparency to enable greater collaboration with sponsors, ...
(Date:9/23/2017)... Janssen Biotech, Inc. (Janssen) announced today that ... U.S. Food and Drug Administration (FDA) for the Biologics ... treatment of moderately to severely active rheumatoid arthritis (RA). ... needed to further evaluate the safety of sirukumab in ... "We are disappointed ...
Breaking Medicine Technology: