Navigation Links
Valerian was first epilepsy drug

The herbal medicine valerian may have been the world's first epilepsy drug, an Australian neurologist says.//

Today, valerian (Valeriana officinalis) is best known as a mild sedative, taken either as a herbal infusion of the dried root or in capsule or tablet form.

But the Italian author Fabio Colonna first mentioned using valerian to control seizures in his 1592 botanical work Phytobasanos.

Colonna said he had controlled his own seizures by taking powdered valerian root several times a day.

By the late 18th and early 19th centuries valerian was often regarded in parts of Europe as the best treatment for controlling seizures.

But as other medicines were developed valerian's use as an antiepileptic drug waned, especially as it smelt and tasted awful.

"As they dry, exposed valerian roots ... develop a characteristic offensive odour resembling that of sweaty socks or dirty underwear," Eadie told ABC Science Online.

This is due to formation of isovaleric acid, believed to be valerian's active ingredient.That's why it is unlikely valerian itself will be developed into an antiepileptic drug, Eadie said.

"No one in their right mind would do a clinical trial. It is too intolerable in the doses needed."

Valerian as a modern-day medicine?

But Eadie said one drug company thinks isovaleramide, a form converted to isovaleric acid in the body, looked promising.

U.S. company NPS Pharmaceuticals has completed preliminary trials on isovaleramide. If isovaleramide works with few side-effects, it may well replace other medications, Eadie said.

"Valerian seems reasonably safe in connection with its use as a sleeping remedy," Eadie said. But he warned people with epilepsy not to experiment with valerian. Researchers did not know the active ingredient; the dose needed to control epilepsy may be many times higher than used for sedation; and doctors do n ot know if valerian can cause a bad reaction when mixed with other medicines.

Courtesy : CoABC Science Online
'"/>




Related medicine news :

1. Infant receives first bloodless liver transplant
2. Oracle Corp. to help build worlds first "Digital Hospital"
3. FDA approves first pocket-sized EKG machine
4. New device for ailing heart fitted into first patient
5. Canada helps in giving birth to world first baby from frozen egg
6. SNUPPY – Woo Suk Hwang reveals World’s first dog cloe
7. Successful creation of human embryos from a single parent for the first time
8. A first for India - IVF baby born of surrogacy
9. Age of first alcoholic drink determined by tendency to cheat
10. Evidence against use of Beta blockers as first choice in the treatment of primary hypertension
11. United Kingdom to perform its first Live Liver Transplant
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/24/2017)... ... February 24, 2017 , ... Yisrayl Hawkins, Pastor and Overseer ... Prophecy concerning this present generation. Yisrayl makes an astounding statement when he says ... He explains that the Bible details the current times so plainly that anyone should ...
(Date:2/24/2017)... , ... February 24, 2017 , ... ... services, which specializes in thought leadership , media relations, social media, content ... services that will be powered through Act-On, an intuitive marketing automation platform. , ...
(Date:2/23/2017)... MA (PRWEB) , ... February 23, 2017 , ... ... and Department of Justice jointly issued a letter to withdraw previous ... accordance with their gender identity. The guidance issued in May 2016 by the ...
(Date:2/23/2017)... ... 2017 , ... The American Cleft Palate-Craniofacial Association (ACPA) is pleased to announce ... a longtime supporter of the event. , "We are pleased that KLS Martin is ... Havlik, 2017 ACPA President. "KLS Martin has a long track record of support of ...
(Date:2/23/2017)... ... February 23, 2017 , ... EBSCO Information Services ... National Institute for Health and Care Excellence (NICE) framework. The agreement allows ... Service (NHS) to search, order and purchase medical and healthcare-related content through ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... Report analyzes the worldwide markets for Endodontic Supplies in US$ ... Canada , Japan , ... Latin America , and Rest of World. ... through 2022. Also, a six-year historic analysis is provided for ... and secondary research. Company profiles are primarily based on public ...
(Date:2/24/2017)... -- ITL Limited, ( ASX : ITD ), une société ... les excellents résultats semestriels clos le 31 décembre 2016 ... complète « Résultats et mise à jour sur la croissance ... Faits marquants ... en hausse de 104 %) Bénéfice par ...
(Date:2/24/2017)... 2017  This report analyzes the worldwide markets for ... Products: Intermediates, Analytical, and Others. The End ... and Agrochemicals. The report provides separate comprehensive analytics for ... Europe , and Rest of World. Annual estimates ... 2022. Also, a six-year historic analysis is provided for ...
Breaking Medicine Technology: