Navigation Links
Vaccine Prevents Prion Disease in Mice

An oral vaccine can prevent mice from developing a brain disease similar to mad cow disease, according to research that will be presented at the American// Academy of Neurology's 59th Annual Meeting in Boston, April 28 – May 5, 2007. Prion diseases, which include scrapie, mad cow disease, and chronic wasting disease, are fatal and there is no treatment or cure.

The disease spreads when an animal eats the body parts of other animals contaminated with prions. The disease causes dementia and abnormal limb movements.

Prion is a protein that is also an infectious agent. The proteins are so similar to proteins found normally that the immune system does not fight them off. To develop a vaccine that would stimulate the mice's immune system, researchers attached prion proteins to a genetically modified strain of Salmonella.

For the study, the mice were orally vaccinated with a safe, attenuated Salmonella strain, which expressed the prion protein. Then they were divided into two groups – those who had high levels of antibodies in their blood and thus responded well to the vaccine and those with low levels of antibodies.

The mice with high levels of antibodies had no symptoms of the disease after 400 days. The mice with low levels of antibodies also had a significant delay in the onset of the disease. It normally takes 120 days for mice that have not been vaccinated to develop the disease.

"These are promising findings," said study author Thomas Wisniewski, MD, of NYU School of Medicine in New York, and a member of the American Academy of Neurology. "We are now in the process of redesigning the vaccine so it can be used on deer and cattle."

Wisniewski said much more work is needed before the vaccine could be considered for humans. "The human version of prion disease usually occurs spontaneously and only rarely because of eating contaminated meat," he said. "But if, for example, a more significant outbreak of chronic wasting disease in deer and elk occurs and if it were transmissible to humans, then we would need a vaccine like this to protect people in hunting areas."

He also noted that a vaccine that decreases the spread of prion disease in animals also reduces the possibility that the disease could infect humans.

Source-Eurekalert/
'"/>




Related medicine news :

1. Vaccine to quit smoking?
2. First Vaccine Designed for Africa Cleared for Testing in Humans
3. Vaccine for Alzheimer’s diseas
4. Health Officials Recommend Flu Vaccine
5. Smallpox Vaccine May Help Fight Cervical Cancer
6. Panacea Biotech To Market Anthrax Vaccine
7. New Prostate Cancer Vaccine Shows Promise
8. Drug Firm Offers to Donate Smallpox Vaccine
9. Vaccine guards against shingles
10. Vaccine for septic conditions
11. A new Vaccine for Pneumonia
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/24/2016)... ... 2016 , ... Mental health watchdog Citizens Commission on Human Rights (CCHR) ... of psychiatry Thomas Szasz, is continuing its protest against the use of electroshock (ECT) ... Atlanta, Georgia. The opening of the exhibit follows CCHR’s recent protest at the annual ...
(Date:5/24/2016)... ... 24, 2016 , ... Boyd Industries, a leading supplier of dental chairs ... product for pediatric dentistry , at AAPD 2016, the annual conference and trade ... The Concealed Delivery Unit keeps dental hand pieces and other anxiety-provoking pieces of the ...
(Date:5/24/2016)... San Mateo, CA (PRWEB) , ... May 24, ... ... society dedicated to advancing the science and clinical practice of radiosurgery, is recognizing ... fields of stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT). The awards will ...
(Date:5/24/2016)... ... May 24, 2016 , ... As reported by MassGeneral.org, ... first penis transplant in the United States . The 64-year-old patient who received the ... The transplant could restore not only a natural appearance, but also urinary and sexual ...
(Date:5/24/2016)... ... May 24, 2016 , ... Harvard Health Publications, the consumer ... will deliver a new series of Q&A videos to clinicians and patients at ... expertise of Harvard Medical School faculty into brief videos that clinicians using vidscrip ...
Breaking Medicine News(10 mins):
(Date:5/20/2016)... ReportsnReports.com adds "Plaque Psoriasis ... research report with comprehensive information on the therapeutic ... comparative analysis at various stages, therapeutics assessment by ... administration (RoA) and molecule type, along with latest ... also reviews key players involved in the therapeutic ...
(Date:5/19/2016)... Cellvizio Highlighted in Physician ... Meeting and 91 st Congress of the ... Technologies (Euronext: MKEA, OTCQX: MKEAY) inventor of Cellvizio®, ... that its Cellvizio platform is being highlighted at ... the month of May. The first meeting highlighting ...
(Date:5/19/2016)... According to a new market research report ... Germany , France , U.K., ... Japan )", published by MarketsandMarkets, The market is ... of 13.9% from 2016 to 2021.      (Logo: ... Tables spread through 26 Pages and in-depth TOC on ...
Breaking Medicine Technology: