Navigation Links
Use Filtered Blood for Transfusion: Expert

University of Rochester researchers who present their analysis in the April journal, Transfusion suggest that filtering white cells from donor blood before// a transfusion is much safer for patients and is long overdue as a national standard for all surgical procedures.

The practice of removing the white cells from blood is called leukoreduction. However, the practice is still not wholly supported in the medical community, nor recommended by the Food and Drug Administration, in spite of the recommendations of two national advisory committees in 10 years voting in favor of all patients in the United States receiving leukoreduced blood, ("universal leukoreduction"). Part of the reason is fear of increased cost.

However, Neil Blumberg, M.D., lead author of the study and a proponent of leukoreduction, argues that several cost-benefit analyses show that an upfront increase of $25 to $35 for each unit of filtered blood is offset by savings from less use of antibiotics, reduced patient time in the ICU, and shorter lengths of hospital stays overall. One study, in fact, estimated that the savings in treating heart surgery complications alone could total $1 billion a year, nationwide.

"Rarely do we come up with a medical advance that saves money and is better for patients at the same time. This is as basic as washing your hands before conducting a physical examination of a patient," Blumberg said. "But despite much scientific evidence that supports this notion, millions of people today are still receiving transfusions that might needlessly be harmful to them. The single most effective and overdue safety measure the FDA could take at this time is to mandate leukoreduction of all transfusions through its regulatory power."

Blumberg's group reviewed approximately 520 abstracts and nine published randomized clinical trials, on the risks and benefits of using leukoreduced blood. They assessed the statistical methods that were used i n each study, and found what they believed to be flawed data in some cases. The chief problem, Blumberg's group discovered, was that some studies included hundreds of patients who never received blood transfusions. These patients would have been irrelevant to a study assessing the risks and/or benefits of certain types of transfusions, because they couldn't have benefited nor could they have been harmed by a transfusion. Furthermore, some studies used data that did not reflect actual investigative results, Blumberg said.

When the data was restricted to patients receiving transfusions, researchers found that post-surgical infection rates dropped from 33 percent to 23 percent. In other words, the relative risk of infection dropped by about 30 percent for the patients with leukoreduced blood.

"Our data would suggest that when you combine all of the safety measures that have been made to the blood supply since the AIDS epidemic, all of those safety adjustments combined are is still less beneficial to patients than the benefits of leukocyte reduction," Blumberg said.

Transfusions are done routinely, and some practitioners are not convinced they hold many risks. But doctors at the University of Rochester, leaders for two decades in the study of "transfusion immunomodulation," believe otherwise. Giving donor blood to someone, Blumberg said, is akin to a temporary organ transplant. In many cases the transfused blood modifies a person's immune system – either in a favorable or unfavorable way – by interacting with the patient's own white cells.

Removing the foreign white cells from transfused blood reduces the chances of a negative reaction by the host immune system. In 1998 the University's Strong Memorial Hospital was among the first hospitals in the country to begin using leukoreduced blood for all cardiac surgery cases. Since then, the hospital has extended its leukoreduction practice to all patients, beginning in 2000.

Related medicine news :

1. Fresh Water Algae Filtered Out With Water Filtration Technique
2. Recommendations for Treatment of Blood Pressue
3. Blood Cells Capable of Regenerating Liver
4. Blood clots likely in long travel
5. Hemochromatosis Patients Blood is Safe
6. Blood transfusions beneficial after heart attacks
7. Blood Pressure Drug may slow wasting in burn victims
8. Levels Of Blood Proteins May Help Heart Disease Care
9. Blood test may identify ovarian cancer
10. A Blood test for suicide risk?
11. Blood Pressure Drugs maintain muscle strength
Post Your Comments:

(Date:10/13/2017)... Calif. (PRWEB) , ... October 13, 2017 , ... Many ... dementia. However, many long-term care insurance companies have a waiver for care if the ... 90-day elimination period, when the family pays for care, is often waived, so the ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer ... one of the most popular and least understood books in the Holy Scriptures, Revelation. ... descriptions that have baffled scholars for centuries. Many have tossed it off as mere ...
(Date:10/13/2017)... ... ... On The Brink”: the Christian history of the United States and the loss of ... William Nowers. Captain Nowers and his wife, Millie, have six children, ten grandchildren, ... Navy. Following his career as a naval aviator and carrier pilot, he spent ...
(Date:10/12/2017)... Wis. (PRWEB) , ... October 12, 2017 , ... ... standard products to meet the demand of today’s consumer and regulatory authorities worldwide. ... of probiotic experts and tested to meet the highest standard. , These ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... that we intend to develop to enable prevention of a major side effect ... hearing loss, especially in pediatric patients. For cisplatin, hearing loss is FDA listed ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... , Oct. 12, 2017   Divoti USA ... up to the standard of the latest FDA requirements, which stipulates ... Anyone in need of Medical ID jewelry such as ... Jewelry are engraved in terms of the new FDA ... Divoti offers this ...
(Date:10/11/2017)... Texas , Oct. 11, 2017  Caris Life ... focused on fulfilling the promise of precision medicine, today ... has joined Caris, Precision Oncology Alliance™ (POA) as its ... cancer centers, the St. Jude Crosson Cancer Institute will ... advance the use of tumor profiling, making cancer treatment ...
(Date:10/10/2017)... COUNTY, Calif. , Oct. 10, 2017  NDS received FDA ... Mobile  — a medical-grade battery-powered display stand specifically designed for endoscopy ... to transform technology into a clinical solution to support the improvement ... Innovative Design ... ZeroWire Mobile Wireless Solution ...
Breaking Medicine Technology: