Navigation Links
Use Filtered Blood for Transfusion: Expert

University of Rochester researchers who present their analysis in the April journal, Transfusion suggest that filtering white cells from donor blood before// a transfusion is much safer for patients and is long overdue as a national standard for all surgical procedures.

The practice of removing the white cells from blood is called leukoreduction. However, the practice is still not wholly supported in the medical community, nor recommended by the Food and Drug Administration, in spite of the recommendations of two national advisory committees in 10 years voting in favor of all patients in the United States receiving leukoreduced blood, ("universal leukoreduction"). Part of the reason is fear of increased cost.

However, Neil Blumberg, M.D., lead author of the study and a proponent of leukoreduction, argues that several cost-benefit analyses show that an upfront increase of $25 to $35 for each unit of filtered blood is offset by savings from less use of antibiotics, reduced patient time in the ICU, and shorter lengths of hospital stays overall. One study, in fact, estimated that the savings in treating heart surgery complications alone could total $1 billion a year, nationwide.

"Rarely do we come up with a medical advance that saves money and is better for patients at the same time. This is as basic as washing your hands before conducting a physical examination of a patient," Blumberg said. "But despite much scientific evidence that supports this notion, millions of people today are still receiving transfusions that might needlessly be harmful to them. The single most effective and overdue safety measure the FDA could take at this time is to mandate leukoreduction of all transfusions through its regulatory power."

Blumberg's group reviewed approximately 520 abstracts and nine published randomized clinical trials, on the risks and benefits of using leukoreduced blood. They assessed the statistical methods that were used i n each study, and found what they believed to be flawed data in some cases. The chief problem, Blumberg's group discovered, was that some studies included hundreds of patients who never received blood transfusions. These patients would have been irrelevant to a study assessing the risks and/or benefits of certain types of transfusions, because they couldn't have benefited nor could they have been harmed by a transfusion. Furthermore, some studies used data that did not reflect actual investigative results, Blumberg said.

When the data was restricted to patients receiving transfusions, researchers found that post-surgical infection rates dropped from 33 percent to 23 percent. In other words, the relative risk of infection dropped by about 30 percent for the patients with leukoreduced blood.

"Our data would suggest that when you combine all of the safety measures that have been made to the blood supply since the AIDS epidemic, all of those safety adjustments combined are is still less beneficial to patients than the benefits of leukocyte reduction," Blumberg said.

Transfusions are done routinely, and some practitioners are not convinced they hold many risks. But doctors at the University of Rochester, leaders for two decades in the study of "transfusion immunomodulation," believe otherwise. Giving donor blood to someone, Blumberg said, is akin to a temporary organ transplant. In many cases the transfused blood modifies a person's immune system – either in a favorable or unfavorable way – by interacting with the patient's own white cells.

Removing the foreign white cells from transfused blood reduces the chances of a negative reaction by the host immune system. In 1998 the University's Strong Memorial Hospital was among the first hospitals in the country to begin using leukoreduced blood for all cardiac surgery cases. Since then, the hospital has extended its leukoreduction practice to all patients, beginning in 2000.
Source-Eurekalert/
'"/>




Related medicine news :

1. Fresh Water Algae Filtered Out With Water Filtration Technique
2. Recommendations for Treatment of Blood Pressue
3. Blood Cells Capable of Regenerating Liver
4. Blood clots likely in long travel
5. Hemochromatosis Patients Blood is Safe
6. Blood transfusions beneficial after heart attacks
7. Blood Pressure Drug may slow wasting in burn victims
8. Levels Of Blood Proteins May Help Heart Disease Care
9. Blood test may identify ovarian cancer
10. A Blood test for suicide risk?
11. Blood Pressure Drugs maintain muscle strength
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... ... April 28, 2016 , ... Sanford Health’s work ... A group of researchers and leaders from Sanford Health were selected to participate ... Its Cultural Impact ” and receive the 2016 Pontifical Key Innovation Award at ...
(Date:4/28/2016)... CA (PRWEB) , ... April 28, 2016 , ... La ... currently number one in Central America and is looking to grow their market share ... for such an exceptional brand as La Sirena Foods and indirectly with ...
(Date:4/28/2016)... ... 28, 2016 , ... Head Over Heels Athletic Arts’ gymnast, Brooklyn Varize, has ... be held at the University of Montana on April 28-May 1. Varize will compete ... , In order to qualify, Varize needed to place top seven all-around in her ...
(Date:4/28/2016)... ... April 28, 2016 , ... The ... a new CDISC standard, Clinical Trial Registry (CTR) XML. Clinical trial registries ... will make it possible to build applications that generate submissions for multiple, ...
(Date:4/28/2016)... ... 28, 2016 , ... Cosmetic Town, an online plastic surgery community, announces the ... was recently revamped and upgraded to allow even more interaction between doctors and patients ... , According to the senior editor of Cosmetic Town, “We are excited that our ...
Breaking Medicine News(10 mins):
(Date:4/26/2016)... , April 26, 2016 Hill-Rom Holdings, Inc. ... a management presentation at the Deutsche Bank 41 st ... 2:50 p.m. EDT. You are invited to listen ... http://ir.hill-rom.com/events.cfm or access it directly at http://edge.media-server.com/m/p/mr4uxgas . ... hour after conclusion of the live event and accessible at ...
(Date:4/26/2016)... DUBLIN , April 26, 2016 ... "Financial Assessment and Credit Risk Analysis of the Biological ... This comprehensive report analyzes the financial assessment ... China . The report provides readers ... key topics all market participants should be aware of. ...
(Date:4/26/2016)... April 26, 2016 ... 2016;9(1):16-20 DOI: http://doi.org/10.17925/USOR.2016.09.01.16 ... Published recently in US Ophthalmic Review, ... Davidson discusses how laser cataract surgery ... cataract surgery: the laser fragments the lens ...
Breaking Medicine Technology: