Navigation Links
Urate Reduces the Risk of Parkinsons Disease

In a new, large-scale, prospective study exploring the link between levels of urate in the blood and risk of Parkinson's disease, researchers from the Harvard School of Public Health (HSPH) have found that high levels of urate are strongly associated with a reduced risk of the disease.

Urate is a normal component of blood, and although high levels can lead to gout, urate might also have beneficial effects because it is a potent antioxidant. Parkinson's disease is a chronic, progressive nerve disorder associated with destruction of brain cells producing dopamine, a neurotransmitter essential to the normal functioning of the central nervous system.

"This is the strongest evidence to date that urate may protect against Parkinson's disease," said lead author Marc Weisskopf, Assistant Professor of Environmental and Occupational Epidemiology at HSPH.

The researchers used the HSPH-based Health Professionals Follow-up Study, a population of male health professionals established in 1986, as the source for their data. The study cohort included more than 18,000 men without Parkinson's disease who had provided blood samples between 1993 and 1995 and whose subsequent health status was followed.

The researchers found that men in the top quartile of blood urate concentration had 55 percent lower risk of developing Parkinson's disease than men in the bottom quartile. This difference was not explained by differences in age or other risk factors for Parkinson's disease.

The results of two previous studies had suggested a possible inverse relation between blood urate and risk of Parkinson's disease, but it is only when the previous data were combined with those of this new study that the evidence became compelling.

The authors hypothesize that urate's antioxidant properties may help dampen the effects of oxidative stress, which appears to contribute to the progressive loss of the dopamine-producing bra in cells that occurs in individuals with Parkinson's disease.

If so, elevating blood urate could be helpful for patients with Parkinson's disease, said Alberto Ascherio, Associate Professor of Nutrition and Epidemiology at HSPH and senior author of the study.

To follow-up on this clue, Ascherio, along with co-author Michael Schwarzschild, a movement disorder specialist at Massachusetts General Hospital, and colleagues at the Parkinson Study Group, a collaborative group of Parkinson's disease researchers from the U.S. and Canada, accessed the databases of two large, randomized studies conducted among patients with early Parkinson's disease.

The preliminary results, presented in abstract form at recent meetings, showed a slower progression of the disease among individuals with high blood urate.

"It is still uncertain whether urate exerts a neuroprotective effect, but approaches to elevating urate levels are nonetheless worth considering as a potential neuroprotective strategy," said Ascherio, who is now collaborating with Schwarzschild and others in the design of a clinical trial in individuals with Parkinson's disease to examine this possibility.

"But elevating blood urate increases the risk of kidney stones and may have adverse cardiovascular effects and should only be attempted in the context of a closely monitored randomized trial until beneficial effects are proven," he added.




'"/>




Related medicine news :

1. High Urate Levels in Blood Linked to Reduced Parkinsons Risk
2. Drug Reduces Risk of Clogged Arteries, Veins
3. Sunshine Reduces MS Risk
4. Estrogen in Food Reduces Cancer Risk
5. Dental Procedure Reduces Preterm Births
6. Vaccine Reduces antibiotic-resistant infections in Children
7. Eating Fiber Reduces The Risk Of Heart Disease
8. Higher Statin Dose Safely Reduces Stroke and Cardiac Arrest
9. Anti-tobacco Advertising Can Reduces smoking Among Teens
10. Eating Fish Reduces Heart Disease
11. Co-trimoxazole Use Reduces Childhood AIDS –Related Death
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/2/2016)... , ... May 02, 2016 , ... As directed by ... of Pennsylvania (HAP) issues its full support to allow certified nurse practitioners (CNP) to ... after they have worked under such supervision for three years and 3,600 hours. , ...
(Date:5/2/2016)... ... May 02, 2016 , ... Eating Recovery Center’s ... eating, mood and anxiety disorders, has rebranded its eating disorder program under a new ... eating disorder treatment facility on May 16. , To celebrate, ERC Chicago will ...
(Date:5/2/2016)... ... May 02, 2016 , ... The National Resident ... Main Residency Match® (“the Match”), the system through which U.S. and international medical ... record-high 30,750 positions were placed in the 2016 Match, and 29,572 were filled ...
(Date:5/2/2016)... ... May 02, 2016 , ... East Los Angeles dentist , ... can visit Dr. Assili to receive any dental extraction treatment for $40 off the ... June 30, 2016. With the lower price, patients can more easily afford extractions to ...
(Date:5/2/2016)... ... May 02, 2016 , ... Zitter Health Insights ... Patient Satisfaction Award that will recognize specialty pharmacies for their achievements in customer ... Insights’ Specialty Pharmacy Patient Satisfaction Survey compiled throughout 2016. Results will be published ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)...  While nearly three-quarters of Americans (71%) are aware ... health, only about half report taking any steps to ... a new survey announced today by Hologic (Nasdaq: ... Osteoporosis Month, Hologic is raising awareness of this major ... Americans. Osteoporosis is a disease that causes ...
(Date:4/29/2016)... 29, 2016 Acquisition Expands ... Product Development Capabilities in North America ... . Indegene ( http://www.indegene.com ), ... acquisition of Skura Corporation,s life science business. Skura,s ... sales enablement technology for life science organizations and ...
(Date:4/28/2016)...  While Abbott,s announced purchase of St. Jude ... and stent business, healthcare research firm Kalorama Information ... into patient monitoring.  Kalorama said that patient monitoring ... with double-digit growth expected the next 5 years, ... Patient Monitoring . Abbott Laboratories agreed to ...
Breaking Medicine Technology: