Navigation Links
Unusual Tumor-Suppressor Gene Switches Off in Lung Cancer

Researchers at Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, have found a tumor suppressor gene that could be of vital significance in the development of head and neck cancers as well as lung cancer. //Their study shows that activating this particular gene could slow up the development of the aforementioned cancers.

The gene, called TCF21 is switched off in tumor cells through a process called DNA methylation. This particular process is reversible and by targeting drugs at this the development of lung cancer can be halted. Tumor-suppressor genes are basically those that prevent the cells from growing without control. When one of these genes is switched off, it could trigger the growth of cancer. In the current study, which appeared online in the January 13 early edition of the Proceedings of the National Academy of Sciences, it was found that TCF21 is pretty unusual since it can alter normal epithelial cells turning them into mesenchymal cells. This particular cell has the ability to migrate to other parts of the body. Therefore, researchers suggest that silencing the TCF21 gene can help in the cancer spreading to other parts of the body. “The fact that this gene is silenced in many cancer types strongly suggests that it plays an important role in cancer development,” said lead investigator Christoph Plass, a professor of molecular virology, immunology and medical genetics and a researcher in the OSU Human Cancer Genetics Program. First author Laura T. Smith added, "Because this gene is silenced by DNA methylation, it might be possible to reactivate it using drugs that reverse the methylation process. This could provide a new strategy for treating these cancers.” Plass' team is now looking at the role of TCF21 in the spread of cancer.

Funding from the National Cancer Institute and the National Institute of Dental and Craniofacial Research supported this research. Cont act: Darrell E. Ward, Medical Center Communications, 614-293-3737, or Darrell.Ward@osumc.eu
'"/>




Related medicine news :

1. A ‘Fit’ of Laughter Silenced by an Unusual Surgey
2. Breast Cancer Treatment Switches to more Modern Therapy
3. Master Switches Found for Adult Blood Stem Cells
4. Fibroids unlikely to Turn Cancerous
5. Virus Level could Predict Cervical Cancer Risk
6. Cancer Doctors Okays Controversial Prostate Therapy
7. Potential New Cancer Gene Identified
8. Consensus on "Combination Therapy" for Breast Cancer
9. Cancers of Colon & Rectum linked to Cigarette Smoking
10. Life Saving Cancer Drugs – From Chicken! Possible Says Dolly’ Creatos
11. The Cancer Rumour mill working over time
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... ... Lean Leadership Series at Zuckerberg San Francisco General Hospital on April 5-7. The ... new behaviors and create new habits. The workshops cover a broad range of ...
(Date:2/12/2016)... ... February 12, 2016 , ... Every winter, someone is ... winter the West Penn Burn Center, part of the Allegheny Health Network, ... to bring you the “Space Heaters Need Space” campaign. , “Space Heaters ...
(Date:2/12/2016)... ... 12, 2016 , ... AssureVest Insurance Group, a locally owned insurance firm with ... will raise funds earmarked to purchase computers and software for Mrs. Harrison’s 2nd and ... is in a low-income area and has more than 60 2nd and 3rd graders ...
(Date:2/12/2016)... ... ... Vail knee specialist Robert LaPrade, MD, PhD was named one of ... of physicians establishing, leading and partnering with ambulatory surgery centers across the United States. ... also known as an ASC, is a modern health care facility focused on providing ...
(Date:2/12/2016)... , ... February 12, 2016 , ... ... the Pittsburgh metro area, celebrates the beginning of the latest charity campaign in ... social skills through art. Donations to this worthy cause are currently being accepted ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... AUSTIN, Texas , Feb. 12, 2016 ... Institute for Robotic Surgery at St. David,s North Austin ... the da Vinci ® Xi ® Surgical ... ® 7000dV. Thiru Lakshman , M.D., ... performed a total proctocolectomy utilizing Integrated Table Motion technology, ...
(Date:2/12/2016)... , 12 februari 2016 ... een toonaangevende leverancier van productie en ontwikkeling ... industrieën, kondigt vandaag een uitbreiding aan van ... haar locatie in Charleston, SC ... geleid tot meerdere recente investeringen. ...
(Date:2/11/2016)... 2016 The primary goal of this research ... on the usage of liquid biopsy. Key information the ... - Timeframe of liquid biopsy adoption amidst future users ... organization type - Sample inflow to conduct liquid biopsy ... serum, and so on. - Correlation analysis of sample ...
Breaking Medicine Technology: