Navigation Links
Unraveling the Secrets of MHC in Human Genome

Seattle scientists are planning to study the Major Histocompatibility Complex (MHC) of the human genome. They have developed a new method for doing the same.// MHC is a large region, found on chromosome 6. It encodes more than 400 known genes, the HLA genes governs tissue type and participate in the immune system by protecting people from infection or by governing susceptibility to autoimmune diseases or cancer. The MHC is one the most diverse regions of the human genome and its diversity are thought to have been shaped by widely varying evolutionary forces. The procedure is described in the Proceedings of the National Academy of Sciences.

This method is an efficient way to map genes in the MHC that are responsible for many human diseases, and might also be useful in studying other gene complexes that have a lot of variability. The researchers are Dr. Zhen Guo and Dr. Mari Malkki of the Division of Clinical Research at the Fred Hutchinson Cancer Research Institute (FHCRC) in Seattle, Dr. Leroy Hood of Seattle’s Institute for Systems Biology, and Dr. Effie Petersdorf of the Division of Clinical Reseearch at FHCRC and the Division of Medical Oncology, Department of Medicine at the University of Washington.

MHC genes have remained unchanged throughout human evolution. MHC also governs the degree of people’s acceptance or rejection of transplanted organs or bone marrow transplants. Identical twins, for example, have identical MCH genes and therefore can receive transplants from each other without risk of rejection. MHC segments are thought to be inherited as an entire block, called a haplotype rather than as separate genes. Haplotypes may be one of the genetic reasons behind complex diseases that are not associated with just one gene or one genetic mutation, but with sets of genes. Researchers plan to expand their method to span the entire MHC, but this would require reconstructing the huge complex into several overlapping segments. This new lab meth od would help the researchers to conduct genetic studies in populations of unrelated individuals.


'"/>




Related medicine news :

1. A Step Towards Unraveling The Schizophrenia And Depression Mystery
2. Personalized Genetics: Unraveling the Secret Code to Good Health.
3. Mobile Phone Messages Assists in Unraveling Murder Mystery
4. Unraveling the Secrets of the Seabed of Andaman off the Thai coasts
5. New Procedure Reveals the Secrets of the Brain
6. Gest Says Will Reveal Damning Secrets On Michael Jackson
7. Unraveling the Secrets of the Seabed of Andaman off the Thai coasts
8. Splenda, Nutrasweet, Fda – Secrets Reveale
9. Secrets of the Hearts Signals
10. Tears Reveal Some of Their Deepest Secrets to Researchers
11. Primitive Yeast Yields Secrets Of Human Cholesterol And Drug Metabolism
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/29/2016)... ... , ... Our bodies are bombarded daily by environmental and lifestyle factors that ... is to adopt a more healthful diet, but too many people think that food ... Nutritionist and the creator of the Newport Beach Cleanse and 14-Day Eating Plan, disagrees ...
(Date:4/29/2016)... ... April 29, 2016 , ... The ... in repaying their loans, more information about their loan terms and accounts, and ... student loan debt, including federal and private loans, has reached $1.3 trillion, with ...
(Date:4/29/2016)... ... 29, 2016 , ... Spine Team Texas, a comprehensive spine physician group specializing ... their physicians has been invited to be a featured speaker at the Texas Society ... on April 30, 2016. , Dr. R. Scott McPherson, a physical medicine and ...
(Date:4/29/2016)... Toronto, ON (PRWEB) , ... April 29, 2016 ... ... GlutenFreeCoupons.ca and the Canadian Celiac Association (CCA), is pleased to announce the launch ... about gluten-free products, nutritional articles, recipes, and more. The purpose of the ...
(Date:4/29/2016)... ... 2016 , ... Reltok Nasal Products proudly announces that Boston Medical Products, Inc., ... and throat specialty, has added the KOTLER NASAL AIRWAY™ to its diverse product line. ... newly patented safety device secured by nasal surgeons onto the floor of the nasal ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... 27, 2016 Global  urinalysis ... billion by 2022, according to a new report ... (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ) , ... efficiency and accuracy delivered by the new generation ... novel urinalysis instruments and consumables. For instance, the ...
(Date:4/27/2016)... , April 27, 2016 ... announced the launch of a Phase 2 clinical study ... hearing in patients undergoing cochlear implantation (CI) surgery. This ... patients in Germany and ... the middle ear at the time of surgery. "Despite ...
(Date:4/26/2016)... 2016 Hill-Rom Holdings, Inc. (NYSE: HRC ... the Deutsche Bank 41 st Annual Health Care Conference ... You are invited to listen to the live discussion ... it directly at http://edge.media-server.com/m/p/mr4uxgas . A recorded replay of ... the live event and accessible at the links above until ...
Breaking Medicine Technology: