Navigation Links
University Participating in West Nile Vaccine Trial

Vanderbilt University Medical Center researchers, in collaboration with investigators at Johns Hopkins University, are beginning a Phase I trial to test// a new vaccine against the West Nile virus.

The mosquito-borne virus, which can cause serious illness, is making its yearly appearance in Middle Tennessee. While no human cases of West Nile have been reported in the state so far this season, mosquitoes collected from around Nashville have tested positive for the virus.

"When West Nile virus first appeared in the United States five or six years ago, it spread remarkably quickly across the country," said Peter Wright, M.D., professor of Pediatrics, Microbiology and Immunology, and Pathology, who is heading up Vanderbilt's efforts in the trial. "There's no part of the country that has not experienced human and bird cases of West Nile."

Although around 80 percent of people infected by West Nile virus show no symptoms, up to 20 percent can experience moderate or severe symptoms ranging from fever, headaches and neck stiffness to neurological problems, paralysis and coma. About one in 150 people infected develop severe illness. People over the age of 50 are at the highest risk, but even healthy people can experience debilitating symptoms lasting several weeks.

There are currently no specific treatments or vaccines to combat West Nile infection, so those infected are consigned to letting the illness run its natural course.

While it is not clear who would most benefit from a West Nile vaccine, Wright suggests that it could be beneficial to certain high-risk populations, such as the elderly, people who work outside and have frequent exposure to mosquitoes, or those in specific geographic regions where West Nile cases are detected.

Finding an effective vaccine against West Nile could also open doors to developing vaccines for other insect-borne illnesses like Dengue fever, which are a priority for vaccin e development because of their considerable global impact.

"We would love to get a vaccine developed for viruses in this class, called arthropod-borne, or as they are commonly called, arboviruses," Wright said. "If we could get one for West Nile, it could be a model for other vaccines."

The vaccine under investigation is built on a backbone of the Dengue virus with bits of the West Nile virus inserted. This method, called a chimeric vaccine, is a relatively new way to engineer a vaccine, Wright said.

"It's conceptually a very interesting vaccine," he said. "It's live but weakened, which has recently been postulated to be the ideal form of immunization…in terms of its broad stimulation of the immune response."

The researchers will test the safety of this vaccine as well as its ability to induce an immune response in healthy volunteers age 18 to 50. The study will also help identify an optimal dosage of the vaccine.

"We can learn a lot from it, and we can measure a lot of things that will inform us about how these vaccines work," Wright said.

Until an effective vaccine is found, public health officials urge the public to take steps to prevent mosquito bites. This includes using insect repellent when outdoors, limiting time spent outside around dawn and dusk when mosquitoes are most active, and getting rid of standing water where mosquitoes breed.

(Source: Newswise)
'"/>




Related medicine news :

1. Researchers at Cornell University as been reported using research fund by false claims
2. A new study by John Hopkins University proposes formula for good health
3. James Cook University urges more medical seats
4. Pill splitting program of University of Michigan can save money
5. Distinguished Scientist Award Conferred on University of Rochester Scientists for Work on Preventing Cavities
6. Yale University guidelines for Physicians and Pharmaceutical industry
7. $ 1.7 Million NYSTAR Award for Binghamton University to Flex Electronics Research Muscle.
8. Florida State University declares a breathtaking study which might solve the Hepatitis C Virus maze and find a cure!
9. Hwang Woo Suk Suspended By Seoul National University
10. Vladeck to head the University of Medicine and Dentistry of New Jersey
11. Rice University wins Prestigious Grants from HHMI
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/27/2017)... ... ... not your typical author. She went from working as a movie extra on Bill Murray’s ... she isn’t swimming as a performing mermaid. , Her book isn’t typical either. In Carothers’ ... comedic look at the dysfunctions of God’s family, before Lucifer was sent to hell. ...
(Date:2/27/2017)... ... February 27, 2017 , ... POUGHKEEPSIE, N. Y. – Peer-reviewed ... that despite scientific studies, the Center for Disease Control ( CDC ) and Infectious ... Kenneth B. Liegner, M.D. has compiled into a single volume a compelling argument ...
(Date:2/27/2017)... Francisco, CA (PRWEB) , ... February 27, 2017 ... ... clinic serving San Francisco and environs, is proud to announce an upgrade to ... information on the upgraded Yelp page on topics as diverse as Platelet Rich ...
(Date:2/26/2017)... ... February 26, 2017 , ... This is an ... world’s first to be ISO/IEC 17025:2005 INAB accredited for Der p 1 (house ... is the globally recognised standard that sets out requirements for the technical competence ...
(Date:2/26/2017)... ... February 26, 2017 , ... ... and reporting for healthcare organizations. This comprehensive and customizable solution empowers StaffBridge ... StaffBridge technology improves staffing efficiency, maximizes resource allocation, collects critical reporting data, ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... 2017 A recent research report published by ... alone is expected to reach a value of $55.8 billion by ... with 28 states have legalized marijuana for medical uses. In 2016, ... , North Dakota , Ohio ... use the drug in medical applications such as chemotherapies and pain ...
(Date:2/27/2017)... , Feb 27, 2017 Period October – December 2016 ... Operating result amounted to SEK -16.4 (-6.4) million Result ... share (-0.22) before and after dilution Cash flow from operating ... ... SEK 0.4 (0.4) million Operating result amounted to SEK -39.5 ...
(Date:2/24/2017)... Research and Markets has announced the addition ... Industry Forecast to 2025" report to their offering. ... The Global Wireless Health ... over the next decade to reach approximately $330.5 billion by 2025. ... for all the given segments on global as well as regional ...
Breaking Medicine Technology: