Navigation Links
Understanding the Mechanism Underlying Embryo Development

Research aimed at understanding the mechanisms underlying embryo development has taken a step forward thanks to collaborative work between biologists specialized in the study of the fruit fly (Drosophila melanogaster) and scientists specialized in the design of mathematical models that simulate the functioning of biological systems.

Specifically, a study of wing formation in Drosophila, led by the researchers Marco Milan, from the Institute for Research in Biomedicine (IRB Barcelona), and Javier Buceta, from the Centre for Research in Theoretical Chemistry (CeRQT), both located within the Barcelona Science Park (PCB), has led to the discovery of a new genetic function involved in this process, and furthers our understanding of the internal laws which regulate it. The article will be published on 11 July in the journal PLoS One.

The development of a living being is based on general laws written into the genetic code of each cell and which enable them to develop a specialist function, modifying the way they divide, their form and their behaviour.

These changes are coordinated through a series of instructions that must be correctly interpreted within the cell, and this means that the information must pass along a pathway of signalling molecules.

These pathways have been conserved across evolution, and therefore studies using models such as the fruit fly provide information about these same processes in humans and other animals.

The Developmental Biology of Drosophila Group from the IRB Barcelona, led by Marco Milan, studies the signals that guide wing development in Drosophila.

The wings are generated from a set of cells grouped into different segments or compartments that never mix with one another, and which enable the symmetrical construction of the dorsal and ventral parts starting from a given limit or border.

This process of subdivision into compartments also takes place du ring the formation of the vertebrate central nervous system, and the genes and signalling pathways involved are conserved in both Drosophila and vertebrate species.

Although biologists already had an intuitive idea of how the limit or border between these compartments was generated, there had been no systematic study taking into account all the relevant elements.

Therefore, and with the backing of a group from the CeQRT of the PCB, led by Javier Buceta, they decided to turn to mathematical modelling as a way of understanding better the internal mechanisms which regulated this process.

In this way they identified certain interactions in the signalling pathways that brought to light a number of contradictions and showed that a key step was missing in their model.

As Milan explains: Thanks to this computer simulation we have found a new genetic function that ensures the stability of the system and has enabled us to test its robustness. This study shows that modelling is a highly useful tool for describing in silico new properties of a biological system and being able to corroborate them subsequently in vivo.

In this regard, Buceta, who leads a group dedicated to modelling biological processes (the SiMBioSys) in the CeRQT, explains that the advantage of these modelling techniques is that they can simulate genetic and cell interactions as a set of mathematical equations and, therefore, to determine the feasibility of a biological mechanism.

In order to study the stability of the system they conducted around 45,000 different in silico experiments, introducing variations in twenty parameters. The results have enabled them to identify the most important system parameters and showed that the biological mechanism maintained its functionality in 91% of the cases analyzed.

Therefore, and with the backing of a group from the CeQRT of the PCB, led by Javier Buceta, they decided to turn to mathematical modelling as a way of understanding better the internal mechanisms which regulated this process.


'"/>




Related medicine news :

1. Understanding The Predictors Of Prostate Cancer
2. Understanding Restless Legs Syndrome
3. Understanding Lung Cancer Metastasis
4. Understanding The Link Between Hormone Replacement and Respiratory Disease
5. Understanding The Risks Of Hormone Therapy
6. Understanding The Link Between Metabolic Syndrome And Drinking Patterns
7. A Better Understanding Of The Brain Network
8. Understanding The Predictor’s Of Alzheimer’s Diseae
9. Understanding The Harmful Effects Of Radiation Exposure
10. Understanding The Origin Of Tumors
11. Understanding Insulin Resistance
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... 2016 , ... Quality metrics are proliferating in cancer care, and are derived ... eye of the beholder, according to experts who offered insights and commentary in the ... Care. For the full issue, click here . , For the American Society ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many women are ... with endometriosis. These women need a treatment plan to not only alleviate symptoms ... can help for preservation of fertility and ultimately achieving a pregnancy. The specialists ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the ... Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. , “We ... new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article ... people are unfamiliar with. The article goes on to state that individuals are now ... of these less common operations such as calf and cheek reduction. The Los Angeles ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. ... The attorneys chosen by their peers for this recognition are considered among the top ... Shareholders received special honors as members of this year’s Legal Elite Hall of Fame: ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Revolutionary technology ... Oticon , industry leaders in advanced audiology and ... Oticon Opn ™, the world,s first internet connected ... for IoT devices.      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ... a number of ,world firsts,: , TwinLink™ ...
(Date:6/23/2016)... , June 23, 2016 The vast majority ... outpatient dialysis facility.  Treatments are usually 3 times a ... per visit, including travel time, equipment preparation and wait ... but especially grueling for patients who are elderly and ... skilled nursing and rehabilitation centers for some duration of ...
(Date:6/23/2016)... June 23, 2016  Experian Health, the ... transforming the patient payment and care experience, ... new products and services that will enhance ... cycle offerings. These award-winning solutions will enable ... remain compliant in an ever-changing environment and ...
Breaking Medicine Technology: