Navigation Links
Understanding the Mechanism Underlying Embryo Development

Research aimed at understanding the mechanisms underlying embryo development has taken a step forward thanks to collaborative work between biologists specialized in the study of the fruit fly (Drosophila melanogaster) and scientists specialized in the design of mathematical models that simulate the functioning of biological systems.

Specifically, a study of wing formation in Drosophila, led by the researchers Marco Milan, from the Institute for Research in Biomedicine (IRB Barcelona), and Javier Buceta, from the Centre for Research in Theoretical Chemistry (CeRQT), both located within the Barcelona Science Park (PCB), has led to the discovery of a new genetic function involved in this process, and furthers our understanding of the internal laws which regulate it. The article will be published on 11 July in the journal PLoS One.

The development of a living being is based on general laws written into the genetic code of each cell and which enable them to develop a specialist function, modifying the way they divide, their form and their behaviour.

These changes are coordinated through a series of instructions that must be correctly interpreted within the cell, and this means that the information must pass along a pathway of signalling molecules.

These pathways have been conserved across evolution, and therefore studies using models such as the fruit fly provide information about these same processes in humans and other animals.

The Developmental Biology of Drosophila Group from the IRB Barcelona, led by Marco Milan, studies the signals that guide wing development in Drosophila.

The wings are generated from a set of cells grouped into different segments or compartments that never mix with one another, and which enable the symmetrical construction of the dorsal and ventral parts starting from a given limit or border.

This process of subdivision into compartments also takes place du ring the formation of the vertebrate central nervous system, and the genes and signalling pathways involved are conserved in both Drosophila and vertebrate species.

Although biologists already had an intuitive idea of how the limit or border between these compartments was generated, there had been no systematic study taking into account all the relevant elements.

Therefore, and with the backing of a group from the CeQRT of the PCB, led by Javier Buceta, they decided to turn to mathematical modelling as a way of understanding better the internal mechanisms which regulated this process.

In this way they identified certain interactions in the signalling pathways that brought to light a number of contradictions and showed that a key step was missing in their model.

As Milan explains: Thanks to this computer simulation we have found a new genetic function that ensures the stability of the system and has enabled us to test its robustness. This study shows that modelling is a highly useful tool for describing in silico new properties of a biological system and being able to corroborate them subsequently in vivo.

In this regard, Buceta, who leads a group dedicated to modelling biological processes (the SiMBioSys) in the CeRQT, explains that the advantage of these modelling techniques is that they can simulate genetic and cell interactions as a set of mathematical equations and, therefore, to determine the feasibility of a biological mechanism.

In order to study the stability of the system they conducted around 45,000 different in silico experiments, introducing variations in twenty parameters. The results have enabled them to identify the most important system parameters and showed that the biological mechanism maintained its functionality in 91% of the cases analyzed.

Therefore, and with the backing of a group from the CeQRT of the PCB, led by Javier Buceta, they decided to turn to mathematical modelling as a way of understanding better the internal mechanisms which regulated this process.


'"/>




Related medicine news :

1. Understanding The Predictors Of Prostate Cancer
2. Understanding Restless Legs Syndrome
3. Understanding Lung Cancer Metastasis
4. Understanding The Link Between Hormone Replacement and Respiratory Disease
5. Understanding The Risks Of Hormone Therapy
6. Understanding The Link Between Metabolic Syndrome And Drinking Patterns
7. A Better Understanding Of The Brain Network
8. Understanding The Predictor’s Of Alzheimer’s Diseae
9. Understanding The Harmful Effects Of Radiation Exposure
10. Understanding The Origin Of Tumors
11. Understanding Insulin Resistance
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... ... (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along ... updates for the primary prevention of cardiovascular diseases during the 15th Annual ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) of ... collection of specialty vendors and unique items from across the nation, this holiday-themed event ... wellness services offered by the VNA. The boutique will be open Saturday, November ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... be giving viewers the lowdown on sciatica in a new episode of "Success ... focuses on current events and innovation and investigates each subject in-depth with passion ...
(Date:10/12/2017)... WILMINGTON, Del. (PRWEB) , ... October 12, 2017 ... ... technology and advisory services for healthcare compliance program management, will showcase a range ... and National Association for Assisted Living (NCAL) Convention and Expo to be held ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( ... today the introduction of an innovative new design of the shoulder pad. The ... get maximum comfort while controlling your pain while using cold therapy. By utilizing ice ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2017 The Rebound mobile app is poised to ... the tide of prescription drug addiction. The app empowers users ... and stepping down their dosage in a safe, controlled manner ... 2017; the first 100,000 people to sign up will enjoy ... ...
(Date:9/27/2017)... NEW YORK , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), ... solutions, today announced that its MyDario product is expected to appear on ... for when The Dr. Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. ... ...
(Date:9/22/2017)... Md. , Sept. 22, 2017  As the ... Republican Senators Bill Cassidy (R-LA) and ... Information notes that the medical device industry is in ... medical device tax, the 2.3% excise tax on medical ... But they also want covered patients, increased visits and ...
Breaking Medicine Technology: