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Understanding the History of HIV Infection Is Vital To Develop a Vaccine

means determining as close as possible to the time of transmission the kind of immune defenses that can restrain viral replication.

"We know that while the host defenses are not going to eliminate the virus, they can achieve some measure of control," Cohen said. "When the control is achieved, the viral growth level is called the 'set point.' We know that people who've achieved a lower set point - that is, better control of their virus - are likely on average to live longer healthier lives and seem to be less likely to transmit the virus to their sexual partners." Cohen said that along with studying the virus and immunological defenses, CHAVI also has the resources to study genetic factors that may be involved in HIV acquisition, including host genetic factors influencing infection and early progression of HIV-1 disease. "CHAVI-001 will probably be able to study enough people so that genetics and the genetics of HIV acquisition and set points can be investigated." There are six sites for CHAVI-001: in Malawi, one in Llongwe and one in Blantyre; in South Africa, one in Johannesburg and one in Durban; and in North Carolina, one at UNC and one at Duke.

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