Navigation Links
Understanding Gene Profiles Could Help Cure A Resistant Form Of Leukemia In Kids

Researchers have uncovered new genes that may help explain why 20 percent of children diagnosed with acute lymphoblastic leukemia // ( ALL ) are resistant to treatment with chemotherapy drugs.

According to researchers chemotherapy cures about 80 percent of ALL cases, but the remaining 20 percent have cancer cells that are resistant to chemotherapy drugs. In order to determine genetic predictors of ALL and the outcome researchers isolated leukemia cells from 173 newly diagnosed ALL patients and tested the cells’ sensitivity to four common chemotherapy drugs. They identified 124 genes that predict resistance to the drugs based on their expression patterns and it was found that the expression of the genes correlated with the likelihood of relapse years after treatment.

It was seen that children who had resistant patterns of gene expression had a three- to 12-fold higher risk of relapse than those whose cells had a sensitive pattern. Researchers also say that the identified genes were involved in a wide range of functions including cell communication, proliferation and development as well as the metabolism of proteins, nucleic acids and carbohydrates.

Studies in the past have identified only three of the 124 genes to be linked with ALL resistance. Thus researchers say the genes uncovered in their recent study point to new targets for future chemotherapy. However, they say that future research needs to define whether the new target genes can be used to treat ALL patients. They also add that doctors might have to fine-tune chemotherapy for each patient.
'"/>




Page: 1

Related medicine news :

1. Understanding The Predictors Of Prostate Cancer
2. Understanding Restless Legs Syndrome
3. Understanding Lung Cancer Metastasis
4. Understanding The Link Between Hormone Replacement and Respiratory Disease
5. Understanding The Risks Of Hormone Therapy
6. Understanding The Link Between Metabolic Syndrome And Drinking Patterns
7. A Better Understanding Of The Brain Network
8. Understanding The Predictor’s Of Alzheimer’s Diseae
9. Understanding The Harmful Effects Of Radiation Exposure
10. Understanding The Origin Of Tumors
11. Understanding Insulin Resistance
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/21/2017)... ... July 21, 2017 , ... The Margarian Law Firm has ... contents of its ginger ale for allegedly containing no ginger. Dr. Pepper produces the ... Group, Inc., plaintiff Gegham Margaryan alleges Canada Dry Ginger Ale claims on its bottle ...
(Date:7/21/2017)... ... July 21, 2017 , ... ... students improve their chances of acceptance to a residency in a United States ... earned degrees outside the U.S. , According to data released by the ECFMG®, ...
(Date:7/21/2017)... ... 21, 2017 , ... West Dermatology is pleased to announce the newest addition ... 2017, Ms. Vu will join West Dermatology’s large network of medical and cosmetic dermatology ... cancer , and more. She graduated from the University of Florida College of Medicine ...
(Date:7/21/2017)... , ... July 21, 2017 , ... ... why concussion rates are on the rise, say researchers presenting their work at ... Toronto, Ontario, Canada. , “The combination of evaluating the patterns of change in ...
(Date:7/20/2017)... ... July 20, 2017 , ... ... bone marrow cancer that progresses rapidly without treatment. Newly diagnosed patients face intense ... chance of reoccurrence and relapse. With such a challenging diagnosis that requires ...
Breaking Medicine News(10 mins):
(Date:7/5/2017)... MINNEAPOLIS , July 5, 2017 Pace Analytical, a company of ... announcing today that they have acquired ESC Lab Sciences, further solidifying their position ... the United States . ... Steve Vanderboom- President and CEO of Pace Analytical ... of ESC Lab Sciences out of Mt Juliet, TN , ...
(Date:7/1/2017)... -- Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH) today ... be broadcast live over the Internet on Thursday, July 27, ... the quarterly results will be made available at 7:30 a.m. ... The live audio webcast can be accessed via Zimmer Biomet,s ... archived for replay following the conference call. ...
(Date:6/30/2017)... Medical (AVACEN) announced the publication of new research in the peer-reviewed ... AVACEN Treatment Method to significantly reduce the widespread pain ... ... ... 200 to 400 million people worldwide according to The National Fibromyalgia ...
Breaking Medicine Technology: