Navigation Links
Understanding Gene Profiles Could Help Cure A Resistant Form Of Leukemia In Kids

Researchers have uncovered new genes that may help explain why 20 percent of children diagnosed with acute lymphoblastic leukemia // ( ALL ) are resistant to treatment with chemotherapy drugs.

According to researchers chemotherapy cures about 80 percent of ALL cases, but the remaining 20 percent have cancer cells that are resistant to chemotherapy drugs. In order to determine genetic predictors of ALL and the outcome researchers isolated leukemia cells from 173 newly diagnosed ALL patients and tested the cells’ sensitivity to four common chemotherapy drugs. They identified 124 genes that predict resistance to the drugs based on their expression patterns and it was found that the expression of the genes correlated with the likelihood of relapse years after treatment.

It was seen that children who had resistant patterns of gene expression had a three- to 12-fold higher risk of relapse than those whose cells had a sensitive pattern. Researchers also say that the identified genes were involved in a wide range of functions including cell communication, proliferation and development as well as the metabolism of proteins, nucleic acids and carbohydrates.

Studies in the past have identified only three of the 124 genes to be linked with ALL resistance. Thus researchers say the genes uncovered in their recent study point to new targets for future chemotherapy. However, they say that future research needs to define whether the new target genes can be used to treat ALL patients. They also add that doctors might have to fine-tune chemotherapy for each patient.
'"/>




Page: 1

Related medicine news :

1. Understanding The Predictors Of Prostate Cancer
2. Understanding Restless Legs Syndrome
3. Understanding Lung Cancer Metastasis
4. Understanding The Link Between Hormone Replacement and Respiratory Disease
5. Understanding The Risks Of Hormone Therapy
6. Understanding The Link Between Metabolic Syndrome And Drinking Patterns
7. A Better Understanding Of The Brain Network
8. Understanding The Predictor’s Of Alzheimer’s Diseae
9. Understanding The Harmful Effects Of Radiation Exposure
10. Understanding The Origin Of Tumors
11. Understanding Insulin Resistance
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/25/2017)... Marietta, GA (PRWEB) , ... April 25, 2017 ... ... implant and instrument solutions, announces the continuation of its strategic partnership with and ... surgeons in developing nations in the safe and effective management of complex spine ...
(Date:4/24/2017)... ORLANDO, FLORIDA (PRWEB) , ... April 24, 2017 ... ... of telehealth technology yesterday, featuring Bring Your Own Device (BYOD) capabilities at Telehealth ... compliment LG CNS’ pre-packaged telehealth bundles, which pairs medical devices with a pre-programmed ...
(Date:4/24/2017)... ... , ... The Santana Telehealth Project was honored with the 2017 ATA Humanitarian ... Association’s annual conference, on April 23 in Orlando, FL. , “I am proud that ... of the poor and underserved in other parts of the world,” said Jonathan Linkous, ...
(Date:4/24/2017)... ... ... As part of the nationwide Days of Remembrance effort led by the ... Nazi persecution, Center for Medicine after the Holocaust (CMATH) announced that it ... Germany and Poland next week. , The Fourth Biennial CMATH Champions Trip to Germany ...
(Date:4/24/2017)... ... 24, 2017 , ... The bar for just about everything—apparel, eyewear, cars and ... air of pop and film stardom.(1) Not to be left out is that most ... now run the gamut from being encrusted with jewels and precious metals to, at ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... , April 20, 2017  RXi Pharmaceuticals ... innovative therapeutics that address significant unmet medical needs, ... from the Company,s consumer product development program, based ... the Society for Investigative Dermatology (SID) 76 th ... advance and promote the sciences relevant to skin ...
(Date:4/20/2017)... April 20, 2017   ZappRx, Inc ., a digital ... prescribing process, today announced it closed $25 million in Series ... capital firm based in Seattle that ... Partners . The Series B round included participation from ... 2014, and GV (formerly Google Ventures). As part ...
(Date:4/20/2017)... 2017 Eyevensys, a private biotechnology ... gene expression technology that enables the safe, local, sustained ... a wide range of ophthalmic diseases, announces it has ... Regulatory Agency (MHRA) to advance its technology into clinical ... The ...
Breaking Medicine Technology: