Navigation Links
Understanding Cancer Initiation Could Help In Early Detection And Prevention

Cancer researchers have discovered that metabolites of natural estrogens can react with deoxyribonucleic acid (DNA) to cause specific damage that initiates the series of events leading to breast, prostate and other human cancers. // This understanding of a common mechanism of cancer initiation could result in cancer prevention and in better assessment of cancer risk.

The researchers will present their findings at the 81st annual meeting of the Southwestern and Rocky Mountain Division of the American Association for the Advancement of Science (SWARM-AAAS) on Friday, April 7, at the University of Tulsa, in Tulsa, Okla.

The symposium – “Catechol Estrogen Quinones as Initiators of Breast and other Human Cancers” – will be led by Drs. Ryszard Jankowiak of the Department of Chemistry, Kansas State University, and Ercole Cavalieri of the Eppley Cancer Institute, University of Nebraska Medical Center.

“We have a novel approach to cancer. We know the initiating step,” said Dr. Cavalieri. “We think prevention of cancer is a problem we can solve by eliminating this initiating step. Estrogens can induce cancer when natural mechanisms of protection do not work properly in our body, and the estrogen quinones are able to react with DNA. In fact, if these protections are insufficient, due to genetic, lifestyle or environmental influences, then cancer can result.

“Now that we have the basic knowledge about a unifying mechanism of cancer initiation, we have a greater sense of urgency to assess people at risk and, at the same time, begin prevention by using specific natural compounds.”

Dr. Cavalieri will discuss a unifying mechanism in the initiation of cancer. He will describe how the catechol estrogen quinones react with DNA to produce specific mutations that may trigger breast, prostate and other human cancers and show how the results of recent studies give rise to targets for preventing the disease.

“We’ve known about these catechol estrogen quinones for a long time, through many different studies that we’ve done, but our most recent results have been quite decisive,” said Dr. Eleanor Rogan of the University of Nebraska Medical Center. “It’s very big news. From here, we will use the information to ultimately try to prevent breast and prostate cancer.”

--Eurekalert
'"/>




Related medicine news :

1. Understanding The Predictors Of Prostate Cancer
2. Understanding Restless Legs Syndrome
3. Understanding Lung Cancer Metastasis
4. Understanding The Link Between Hormone Replacement and Respiratory Disease
5. Understanding The Risks Of Hormone Therapy
6. Understanding The Link Between Metabolic Syndrome And Drinking Patterns
7. A Better Understanding Of The Brain Network
8. Understanding The Predictor’s Of Alzheimer’s Diseae
9. Understanding The Harmful Effects Of Radiation Exposure
10. Understanding The Origin Of Tumors
11. Understanding Insulin Resistance
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... Bethesda, MD (PRWEB) , ... October 12, 2017 , ... ... Award of Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s ... 4 – 8. , In honor of Morris F. Collen, a pioneer in the ...
(Date:10/12/2017)... Rockville, Maryland (PRWEB) , ... October 12, 2017 ... ... a magnetic drug delivery system that we intend to develop to enable prevention ... regimens can lead to severe hearing loss, especially in pediatric patients. For cisplatin, ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in healthcare events ... Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during the ... The annual award competition recognizes editorial and design excellence across a range of sectors. ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... On Saturday, ... a treadmill relay – Miles by Moonlight to raise money for the American Heart ... or more. , Teams will work together to keep their treadmills moving for ...
(Date:10/12/2017)... ... October 12, 2017 , ... Health Literacy Innovations (HLI), ... software tool, and the Cancer Patient Education Network (CPEN), an independent professional organization ... a new strategic alliance. , As CPEN’s strategic partner, HLI will help ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2017 Diplomat Pharmacy, Inc. (NYSE: ... Consulting, LLC , and named its founder as Diplomat,s ... Tennessee , will operate under Diplomat ... service offerings for health care partners to include IT ... "In an interoperable world, technology delivers comprehensive ...
(Date:10/2/2017)... PHILADELPHIA , Oct. 2, 2017 Halo Labs announces ... particle analysis system called the HORIZON at MIBio 2017 in ... analyzes subvisible and visible particulate matter in biopharmaceutical samples with unprecedented ... use of the novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
(Date:9/28/2017)... Sept. 28, 2017 Cohen Veterans Bioscience and ... use of wearable and home sensors for real-time monitoring ... Signal Foundation, a nonprofit organization focused on disruptive health ... an affordable analytical system to record and integrate behavioral, ... ...
Breaking Medicine Technology: