Navigation Links
Understanding Cancer Initiation Could Help In Early Detection And Prevention

Cancer researchers have discovered that metabolites of natural estrogens can react with deoxyribonucleic acid (DNA) to cause specific damage that initiates the series of events leading to breast, prostate and other human cancers. // This understanding of a common mechanism of cancer initiation could result in cancer prevention and in better assessment of cancer risk.

The researchers will present their findings at the 81st annual meeting of the Southwestern and Rocky Mountain Division of the American Association for the Advancement of Science (SWARM-AAAS) on Friday, April 7, at the University of Tulsa, in Tulsa, Okla.

The symposium – “Catechol Estrogen Quinones as Initiators of Breast and other Human Cancers” – will be led by Drs. Ryszard Jankowiak of the Department of Chemistry, Kansas State University, and Ercole Cavalieri of the Eppley Cancer Institute, University of Nebraska Medical Center.

“We have a novel approach to cancer. We know the initiating step,” said Dr. Cavalieri. “We think prevention of cancer is a problem we can solve by eliminating this initiating step. Estrogens can induce cancer when natural mechanisms of protection do not work properly in our body, and the estrogen quinones are able to react with DNA. In fact, if these protections are insufficient, due to genetic, lifestyle or environmental influences, then cancer can result.

“Now that we have the basic knowledge about a unifying mechanism of cancer initiation, we have a greater sense of urgency to assess people at risk and, at the same time, begin prevention by using specific natural compounds.”

Dr. Cavalieri will discuss a unifying mechanism in the initiation of cancer. He will describe how the catechol estrogen quinones react with DNA to produce specific mutations that may trigger breast, prostate and other human cancers and show how the results of recent studies give rise to targets for preventing the disease.

“We’ve known about these catechol estrogen quinones for a long time, through many different studies that we’ve done, but our most recent results have been quite decisive,” said Dr. Eleanor Rogan of the University of Nebraska Medical Center. “It’s very big news. From here, we will use the information to ultimately try to prevent breast and prostate cancer.”


Related medicine news :

1. Understanding The Predictors Of Prostate Cancer
2. Understanding Restless Legs Syndrome
3. Understanding Lung Cancer Metastasis
4. Understanding The Link Between Hormone Replacement and Respiratory Disease
5. Understanding The Risks Of Hormone Therapy
6. Understanding The Link Between Metabolic Syndrome And Drinking Patterns
7. A Better Understanding Of The Brain Network
8. Understanding The Predictor’s Of Alzheimer’s Diseae
9. Understanding The Harmful Effects Of Radiation Exposure
10. Understanding The Origin Of Tumors
11. Understanding Insulin Resistance
Post Your Comments:

(Date:10/13/2015)... ... October 13, 2015 , ... Altec Products, ... sponsorship of the Microsoft Dynamics AXUG, GPUG and NAVUG Summits to take place ... NAVUG Summit are independent user conferences designed and led by users to provide ...
(Date:10/13/2015)... ... October 13, 2015 , ... Element Blue ™, a ... new company, RightSensor™ LLC, an Internet of Things (IoT) hardware supplier that delivers ... fully-managed approach for customers requiring sensor hardware for critical data environments. , RightSensor™, ...
(Date:10/13/2015)... ... 13, 2015 , ... Relay (, a technology company that ... significant contract that will provide its award-winning private messaging solution to Independence Blue ... success of its Relay program, IBX Wire™, which now has over 550,000 members ...
(Date:10/13/2015)... ... October 13, 2015 , ... e-con Systems Inc., a leading embedded ... See3CAM_CU40, the industry’s first RGB-IR pixel format camera with a USB 3.0 interface ... e-con’s See3CAM family of UVC USB 3.0 cameras, is based on the 1/3-inch OV4682 ...
(Date:10/13/2015)... Tenn. (PRWEB) , ... October 13, 2015 , ... A ... and that’s why SmileCareClub , the leading remote invisible aligner system, has joined ... who would otherwise go without it. For each aligner treatment plan purchased, SmileCareClub will ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)...  EndoChoice Holdings, Inc. (NYSE:  GI) announced today that ... on Thursday, November 5, 2015 before the market open. ... . --> EndoChoice will hold ... 9:00 a.m. ET to discuss the results. The dial-in ... 317-5469 for international callers. A live webcast of the ...
(Date:10/13/2015)... Regen BioPharma, Inc. , ... Harry Lander , PhD as its new president.  Dr. Lander ... David Koos as Regen BioPharma prepares to take the ... --> Regen BioPharma, Inc. , (OTCBB: RGBP, ... , PhD as its new president.  Dr. Lander will work ...
(Date:10/13/2015)... 13, 2015 China Jo-Jo Drugstores, ... Jo-Jo "), a leading China-based retail, wholesale and online ... own online and retail pharmacies, announced preliminary half year ... online pharmacy through , growing 438% year ... 25%. China Jo-Jo,s online sales ...
Breaking Medicine Technology: