Navigation Links
Unchecked Cellular Repair Pathway Causes Liver Cancer

Researchers from Duke University Medical Center and John Hopkins University School of Medicine have found that an uncontrolled cell signaling pathway that plays a vital role in the embryonic development and the liver's own response // to injury lead to the development of liver cancer.

The cell-signalling pathway called Hedgehog is present only in immature, stem-like liver cells. This discovery could lead to the development of targeted treatment of liver cancer, which happens to be one of the top causes of cancer-related deaths in the world. Jason Sicklick, M.D., a postdoctoral fellow at Duke and lead author of the study said that the researcher were able to switch off the Hedgehog pathway, which resulted in the death of the cancer cells, but spared the healthy cells that were free of cancer. "Currently, there are no good chemotherapies for liver cancer, and many people with advanced liver disease are too ill for surgery to remove tumors," Sicklick said. "There is a desperate need for effective anticancer treatments that are safe for patients with liver disease." He added that new diagnostic tests to detect cancer could also be developed in this way, "Currently, there are no good chemotherapies for liver cancer, and many people with advanced liver disease are too ill for surgery to remove tumors," Sicklick said. "There is a desperate need for effective anticancer treatments that are safe for patients with liver disease." Liver cancer is rare in people with healthy lifestyles. It is often caused in people who abuse alcohol thereby developing cirrhosis and hepatitis leading to cancer. Anna Mae Diehl, M.D., chief of Duke's gastroenterology division and senior author on the study said that the increasing incidence of obesity has meant that the risk of liver cancer has also increased, "If the liver is injured badly, it uses some of the same mechanisms to repair itself as a fetus uses in growing a liver," Diehl said. The study is to appear in the April 4, 2006, issue of Carcinogenesis. Contact Becky Oskin , 919-684-4966 or 919-684-4148 becky.oskin@duke.edu Source: Eurekalert
'"/>




Related medicine news :

1. Unchecked Spread of HIV/AIDS May Impact Eco Growth: UN Report
2. Use of Cellular Phones associated with Increased risk of Brain Tumors
3. Researchers Discover Two Proteins Involved In Cellular Destruction Of HIV Virus
4. New Way to Open Cellular Ion Channels, Implications for Drug Design
5. Cellular System Causing Destruction Of Faulty Proteins In Cystic Fibrosis Identified
6. Gene May Regulate Cellular Aging
7. Cellular Cues Identified for Stroke Recovery
8. Cellular Pathway Yields Potential New Weapon in Vaccine Arsenal
9. Cocaines Use During Pregnancy May Cause Lasting Cellular Effects
10. Brain Cell Repair Loss disclosed
11. Stem Cells To Repair Heart Damage
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: