Navigation Links
Unchecked Cellular Repair Pathway Causes Liver Cancer

Researchers from Duke University Medical Center and John Hopkins University School of Medicine have found that an uncontrolled cell signaling pathway that plays a vital role in the embryonic development and the liver's own response // to injury lead to the development of liver cancer.

The cell-signalling pathway called Hedgehog is present only in immature, stem-like liver cells. This discovery could lead to the development of targeted treatment of liver cancer, which happens to be one of the top causes of cancer-related deaths in the world. Jason Sicklick, M.D., a postdoctoral fellow at Duke and lead author of the study said that the researcher were able to switch off the Hedgehog pathway, which resulted in the death of the cancer cells, but spared the healthy cells that were free of cancer. "Currently, there are no good chemotherapies for liver cancer, and many people with advanced liver disease are too ill for surgery to remove tumors," Sicklick said. "There is a desperate need for effective anticancer treatments that are safe for patients with liver disease." He added that new diagnostic tests to detect cancer could also be developed in this way, "Currently, there are no good chemotherapies for liver cancer, and many people with advanced liver disease are too ill for surgery to remove tumors," Sicklick said. "There is a desperate need for effective anticancer treatments that are safe for patients with liver disease." Liver cancer is rare in people with healthy lifestyles. It is often caused in people who abuse alcohol thereby developing cirrhosis and hepatitis leading to cancer. Anna Mae Diehl, M.D., chief of Duke's gastroenterology division and senior author on the study said that the increasing incidence of obesity has meant that the risk of liver cancer has also increased, "If the liver is injured badly, it uses some of the same mechanisms to repair itself as a fetus uses in growing a liver," Diehl said. The study is to appear in the April 4, 2006,
'"/>




Page: 1 2

Related medicine news :

1. Unchecked Spread of HIV/AIDS May Impact Eco Growth: UN Report
2. Use of Cellular Phones associated with Increased risk of Brain Tumors
3. Researchers Discover Two Proteins Involved In Cellular Destruction Of HIV Virus
4. New Way to Open Cellular Ion Channels, Implications for Drug Design
5. Cellular System Causing Destruction Of Faulty Proteins In Cystic Fibrosis Identified
6. Gene May Regulate Cellular Aging
7. Cellular Cues Identified for Stroke Recovery
8. Cellular Pathway Yields Potential New Weapon in Vaccine Arsenal
9. Cocaines Use During Pregnancy May Cause Lasting Cellular Effects
10. Brain Cell Repair Loss disclosed
11. Stem Cells To Repair Heart Damage
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Unchecked Cellular Repair Pathway Causes Liver Cancer

(Date:7/1/2015)... ... 2015 , ... As if mood swings, cramps and child labor weren’t enough ... leg pain. Northeast Houston Vein Center is offering tips on the treatment options for ... is underdiagnosed and often overlooked. Many women experience the tiredness, achiness, restless legs, cramps ...
(Date:7/1/2015)... ... ... Trevor L. Williams, DMD holds a Bachelor of Science degree in Biomedical Sciences ... in Microbiology. He graduated from the University of Florida College of Dentistry in 2015 ... and the Academy of General Dentistry. Dr. Williams was born in Tampa and is ...
(Date:7/1/2015)... ... July 01, 2015 , ... ... of IBM software products, announced today that it has received trademark protection for ... display and detailed analysis of data from multiple sources providing an environment where ...
(Date:7/1/2015)... ... 2015 , ... A Priority Setting Partnership put in place ... they hope will guide future mesothelioma research. Surviving Mesothelioma has just posted an ... , More than 450 mesothelioma patients, caregivers, and healthcare professionals answer the mesothelioma ...
(Date:7/1/2015)... York (PRWEB) , ... July 01, 2015 , ... Author Francesca Camp wasn’t ... fell into her lap, so too did her support of the practice; a terrible car ... , In her new book, “Do I Need It ? (And What if I ...
Breaking Medicine News(10 mins):Health News:Northeast Houston Vein Center Offers Tips for Women with Leg Pain 2Health News:Northeast Houston Vein Center Offers Tips for Women with Leg Pain 3Health News:Trevor L. Williams, D.M.D. Joins Enlow & Vance Dental Partners in Tampa, Florida 2Health News:Element Blue Receives Trademark Protection from U.S. Patent and Trademark Office for Its Award Winning SensorInsight® Software 2Health News:Element Blue Receives Trademark Protection from U.S. Patent and Trademark Office for Its Award Winning SensorInsight® Software 3Health News:Element Blue Receives Trademark Protection from U.S. Patent and Trademark Office for Its Award Winning SensorInsight® Software 4Health News:New Report Identifies Top 10 Mesothelioma Research Priorities, According to Surviving Mesothelioma 2Health News:Francesca Camp’s New Book Unmasks Plastic Surgery Advice 2
... the battle against malignant brain tumors, dual implantation ... showed promising results in a study led by ... of Cincinnati (UC) and University Hospital. , The ... Journal of Neurosurgery, revealed that patients treated with ...
... Gornick LLP, Bailey Perrin Bailey LLP and Weitz &, ... United, States District Court for the Eastern District of New York ... Co., Inc. and Schering-Plough Corporation., ... the law,firms of Parker Waichman Alonso LLP, Becnel Law Firm, LLC, ...
... Five Such Cases Known Worldwide, NEW HYDE PARK, N.Y., ... physicians at LIJ Medical,Center, 25-year-old Stacey Gayle can now look ... radio. At a news conference today, Ms.,Gayle and her doctors ... robbed her of her health, but of the very important,gift ...
... Jan Marini Skin Research,Inc. (JMSR; http://www.janmarini.com ) today ... Age Intervention Eyelash Conditioner,and Age Intervention Masses of Lashes ... patent infringement lawsuit by Allergan Pharmaceutical as,one reason for ... suspend,these products while we strategically review our options," said ...
... general use, experts caution , , THURSDAY, Jan. 17 (HealthDay News)-- Some ... modifies the body,s immune response. , A study in the Jan. ... no history of heart attacks, as well as those in a ... and of subsequent hospitalizations with such a treatment. , But ...
... a lack of knowledge of health risks posed by ... cell phone technology and use continues to expand and evolve, ... potential health risks associated with long-term exposure to radiofrequency energy. ... women and fetuses -- as well as workers subject to ...
Cached Medicine News:Health News:Combined radiation seed, chemotherapy wafer implants show promise in treating cancerous brain tumors 2Health News:Former Sufferer of Rare Disease Called Musicogenic Epilepsy Thanks LIJ Medical Team That Ended Her Seizures and Gave Her Back the Gift of Music 2Health News:Jan Marini Skin Research Suspends Sales of Popular Eyelash Products 2Health News:Immune Therapy May Help Some Heart Failure Patients 2Health News:Immune Therapy May Help Some Heart Failure Patients 3Health News:Report Urges More Research Into Cell Phones 2Health News:Report Urges More Research Into Cell Phones 3
(Date:7/1/2015)... July 1, 2015  Unilife Corporation (NASDAQ: UNIS ... of injectable drug delivery systems, announced today that its ... June 30, 2015. This amendment removed a covenant that ... cash receipts from customers during the six months ended ... any of the terms of the debt agreement as ...
(Date:7/1/2015)... July 1, 2015 Qiming Venture Partners, today ... Managing Partner effective immediately. William has been ... and participated in many Qiming healthcare deals, and assisted ... Chinese market. Qiming, s success in healthcare is not ... distinguished himself with his outstanding advocacy and service mentality ...
(Date:7/1/2015)... 2015 According to a new ... Method (Biochemical (Calcium Phosphate, Lipofection, Dendrimers), Physical (Electroporation, Nucleofection), ... Global Forecast to 2020", published by MarketsandMarkets, the Transfection ... $957.9 Million by 2020 with a CAGR of 7.2% ... market T ables and 33 F ...
Breaking Medicine Technology:Unilife and OrbiMed Amend Debt Financing Agreement 2Unilife and OrbiMed Amend Debt Financing Agreement 3Qiming Announces the Promotion of William Hu to Managing Partner 2Transfection Reagents and Equipment Market Worth $957.9 Million by 2020 2Transfection Reagents and Equipment Market Worth $957.9 Million by 2020 3Transfection Reagents and Equipment Market Worth $957.9 Million by 2020 4
... Pharmaceuticals Inc. (Nasdaq: CPIX ) announced today that it will report first ... 2010 .  A conference call and live Internet webcast will be held on ... to discuss the results. , , ... in the call, please dial 877-303-1298 (for U.S. callers) or 253-237-1032 (for international ...
... Israel , May 3, 2010 , , ... The Company is Developing an Artificial Sphincter (the AOS-C1000) to,Provide Bowel Control and Prevent Clinical Complications for ... Stimatix GI, located in the Misgav Venture Accelerator, ... with a new means of bowel,control. , , , ...
Cached Medicine Technology:Cumberland Pharmaceuticals To Announce First Quarter 2010 Financial Results on May 13, 2010 2Stimatix GI Reports Encouraging Interim Results 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: