Navigation Links
Unchecked Cellular Repair Pathway Causes Liver Cancer

Researchers from Duke University Medical Center and John Hopkins University School of Medicine have found that an uncontrolled cell signaling pathway that plays a vital role in the embryonic development and the liver's own response // to injury lead to the development of liver cancer.

The cell-signalling pathway called Hedgehog is present only in immature, stem-like liver cells. This discovery could lead to the development of targeted treatment of liver cancer, which happens to be one of the top causes of cancer-related deaths in the world. Jason Sicklick, M.D., a postdoctoral fellow at Duke and lead author of the study said that the researcher were able to switch off the Hedgehog pathway, which resulted in the death of the cancer cells, but spared the healthy cells that were free of cancer. "Currently, there are no good chemotherapies for liver cancer, and many people with advanced liver disease are too ill for surgery to remove tumors," Sicklick said. "There is a desperate need for effective anticancer treatments that are safe for patients with liver disease." He added that new diagnostic tests to detect cancer could also be developed in this way, "Currently, there are no good chemotherapies for liver cancer, and many people with advanced liver disease are too ill for surgery to remove tumors," Sicklick said. "There is a desperate need for effective anticancer treatments that are safe for patients with liver disease." Liver cancer is rare in people with healthy lifestyles. It is often caused in people who abuse alcohol thereby developing cirrhosis and hepatitis leading to cancer. Anna Mae Diehl, M.D., chief of Duke's gastroenterology division and senior author on the study said that the increasing incidence of obesity has meant that the risk of liver cancer has also increased, "If the liver is injured badly, it uses some of the same mechanisms to repair itself as a fetus uses in growing a liver," Diehl said. The study is to appear in the April 4, 2006, issue of Carcinogenesis. Contact Becky Oskin , 919-684-4966 or 919-684-4148 becky.oskin@duke.edu Source: Eurekalert
'"/>




Related medicine news :

1. Unchecked Spread of HIV/AIDS May Impact Eco Growth: UN Report
2. Use of Cellular Phones associated with Increased risk of Brain Tumors
3. Researchers Discover Two Proteins Involved In Cellular Destruction Of HIV Virus
4. New Way to Open Cellular Ion Channels, Implications for Drug Design
5. Cellular System Causing Destruction Of Faulty Proteins In Cystic Fibrosis Identified
6. Gene May Regulate Cellular Aging
7. Cellular Cues Identified for Stroke Recovery
8. Cellular Pathway Yields Potential New Weapon in Vaccine Arsenal
9. Cocaines Use During Pregnancy May Cause Lasting Cellular Effects
10. Brain Cell Repair Loss disclosed
11. Stem Cells To Repair Heart Damage
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/19/2017)... ... ... With the cold weather here, many people will have to clear snow with snow blowers ... of snow, but they can be dangerous when used incorrectly. That’s why Amica Insurance ... proper use of snow blowers:, , When removing wet snow or ...
(Date:1/19/2017)... ... ... Cosmetic Town, an online plastic surgery community, begins 2017 with an update ... their readers to get the information they desire. The procedures are now listed according ... on those particular areas. , “We are excited to streamline our listings in a ...
(Date:1/19/2017)... ... 2017 , ... Bio-Optronics Inc. is proud to announce the ... to seamlessly integrate and streamline the way researchers prepare and conduct patient visits. ... and improving efficiency significantly for users – a first in the CTMS industry. ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... staff members in 2017 who are passionate about making a difference in the ... and headquartered in Tampa, UMA, a nonprofit healthcare educational institution, has more than ...
(Date:1/19/2017)... ... 2017 , ... For the third year running, Noto Insurance ... surrounding area, is inaugurating a charity event to help raise funds for ... Gehrig's disease or motor neurone disease, is a deadly neurological disorder that affects ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)...   Science Exchange , the leading marketplace ... the first five replication studies from the ... in eLife today. Despite intense scrutiny around reproducibility ... evaluation of reproducibility rates that may identify specific ... assessments of reproducibility, the results of this project ...
(Date:1/19/2017)... January 18, 2017 , , Marks E-QURE ... distribution agreement, following similar agreements in Israel ... Wound care is $2 5 billion ... E-QURE Corp. (OTCQB: EQUR), a leader in medical devices for the treatment of ... Médica Equipos Médicos S.A.S. (TeckMedica) in Colombia for the ...
(Date:1/19/2017)... , Jan. 18, 2017 The drug ... billion by 2021 from USD 1,179.20 billion in 2016, ... Increasing prevalence of chronic diseases, increasing demand for ... factors driving the growth of this market. Whereas, self-administration ... generic drugs offer significant growth opportunities for players operating ...
Breaking Medicine Technology: