Navigation Links
Ultrasound helps stroke treatment

According to surgeons, they use sound waves to pulverize gallstones and now stroke experts are trying to determine if less powerful ultrasound can improve the efficacy of the clot-busting drugs used to restore blood flow to the brain.// Dr. Andrei Alexandrov, of the University of Texas, said he was using intracranial ultrasound to track the efficacy of the clot-busting drug called tPA or alteplase.

Shortly after initiating the ultrasound monitoring, emergency room nurses told him patients "were getting better really fast." At that point, he decided to initiate a pilot study to determine if ultrasound could boost the clot-busting or thrombolysis ability of tPA, he explained Friday during a news briefing at the 27th International Stroke Conference in San Antonio.

Alexandrov uses a hand-held ultrasound device fitted into a frame "like the frame inside a construction worker's hard hat," he said. Using a Food and Drug Administration-approved diagnostic frequency setting of 2 megahertz, the device focuses on the clot while the tPA is infused over a period of about an hour and then continues to track the clot for an hour after infusion.

Alexandrov said sound waves are very powerful and a low thumping "could mechanically shake apart a clot." But that approach would be dangerous because it would be difficult to control. The FDA approved diagnostic frequency is "faster but gentler. It creates micro-vibrations that work on the surface of the clot to open up more surface that the tPA can then bind to and penetrate," he said.

The pilot study enrolled 40 patients, average age 65. Thirty-seven percent had complete clearance of clots, called recanalization, within two hours of treatment initiation and "70 percent had a partial clearance of clots," Alexandrov said in an interview with United Press International.

He cautioned, however, the pilot study was designed to test the safety not efficacy of the approach. "We did prove that ultrasou nd is safe when used in this way," he said. Dr. Gregory del Zoppo, of Scripps Research Institute in La Jolla, Calif., and a member of the American Stroke Association's executive committee told UPI ultrasound "has been looked at by a number of investigators. There is no doubt that sound waves can (break-up) clots, but safety is a concern."

While Alexandrov's study, which was designed as a safety trial, found no safety problems using the diagnostic ultrasound devices, del Zoppo said he doubts such low power devices actually improve the recanalization rate of clot-busting drugs. The temptation, he said, will be to use more powerful devices "and that's where safety becomes an issue."

He noted researchers in Germany and in Oregon tried putting ultrasound clot-busting probes on catheters that were guided to the clot site but those studies were halted when the sound waves not only dissolved the clots but also damaged artery walls.

Moreover, del Zoppo said the recanalization rates cited by Alexandrov are not especially high. But Alexandrov said his early results are so promising a new phase II study aimed at determining the most effective frequency has already begun. So far 30 patients have been treated and the goal is to enroll 120 patients.


'"/>




Related medicine news :

1. Ultrasound test may detect heart condition early
2. Ultrasound Screening Could Improve The Outcome Of Critically ill Patients
3. The Safety Of Prenatal Ultrasounds Questioned
4. Stanford Medical Center Implements The First Virtual Cardiac Ultrasound
5. Ultrasounds To Detect Changes In Heart Motions
6. Ultrasound may mean end to classic stethoscope
7. Optical Imaging Added To Ultrasound To Improve Imaging Of Breast Cancer
8. Three In One Ultrasound Probe For 3-D Imaging Of Heart And Tissue Destruction Developed
9. Fetal Development Face The Threat By Frequent Ultrasounds
10. Ultrasound Can Detect Breast Cancer in Pregnant Women
11. Ultrasound Helps Detecting Cancer In Pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... , ... “The Journey: From the Mountains to the Mission Field”: the story ... the Philippines. “The Journey: From the Mountains to the Mission Field” is the creation ... has taught all ages and currently teaches a class of ladies at her church, ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... services for healthcare compliance program management, will showcase a range of technology and ... for Assisted Living (NCAL) Convention and Expo to be held October 14–18, 2017 ...
(Date:10/12/2017)... ... , ... Planet Fitness, one of the largest and fastest growing franchisors and ... flagship location in Covington, LA at 401 N. U.S. Highway 190, in January of ... Depot in the Holiday Square shopping center. Its location allows it to serve both ...
(Date:10/12/2017)... ... 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one of the ... new design of the shoulder pad. The shoulder pad provides optimal support and ... pain while using cold therapy. By utilizing ice and water that is circulated from ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally ... care, have expanded their existing home health joint venture through an agreement, effective ... operating a joint venture home health company with Asante, delivering clinically integrated care, ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... , Sept. 22, 2017 AVACEN Medical (AVACEN) ... is now successfully helping those with the widespread pain ... Fibromyalgia diagnosed Amanda in Essex, England ... washing my hair, experiencing no sleep at all, tremendous ... spasm… I cannot recommend [the AVACEN 100] enough, how ...
(Date:9/18/2017)... , Pa. and KALAMAZOO, Mich. , ... Allentown, Penn. , and OptiMed Specialty Pharmacy of ... business partnership to offer a strategic hub service that ... Healthcare,s highly sought-after personal spirometer, Spiro PD 2.0, and ... A spirometer is a medical device used to ...
(Date:9/12/2017)... , Sept. 12, 2017   EcoVadis , the leading platform ... published the first annual edition of its Global CSR Risk and Performance ... evaluated by EcoVadis, based on Scorecard Ratings that analyzed nearly 800,000 data ... ... ...
Breaking Medicine Technology: