Navigation Links
Ultrasound helps stroke treatment

According to surgeons, they use sound waves to pulverize gallstones and now stroke experts are trying to determine if less powerful ultrasound can improve the efficacy of the clot-busting drugs used to restore blood flow to the brain.// Dr. Andrei Alexandrov, of the University of Texas, said he was using intracranial ultrasound to track the efficacy of the clot-busting drug called tPA or alteplase.

Shortly after initiating the ultrasound monitoring, emergency room nurses told him patients "were getting better really fast." At that point, he decided to initiate a pilot study to determine if ultrasound could boost the clot-busting or thrombolysis ability of tPA, he explained Friday during a news briefing at the 27th International Stroke Conference in San Antonio.

Alexandrov uses a hand-held ultrasound device fitted into a frame "like the frame inside a construction worker's hard hat," he said. Using a Food and Drug Administration-approved diagnostic frequency setting of 2 megahertz, the device focuses on the clot while the tPA is infused over a period of about an hour and then continues to track the clot for an hour after infusion.

Alexandrov said sound waves are very powerful and a low thumping "could mechanically shake apart a clot." But that approach would be dangerous because it would be difficult to control. The FDA approved diagnostic frequency is "faster but gentler. It creates micro-vibrations that work on the surface of the clot to open up more surface that the tPA can then bind to and penetrate," he said.

The pilot study enrolled 40 patients, average age 65. Thirty-seven percent had complete clearance of clots, called recanalization, within two hours of treatment initiation and "70 percent had a partial clearance of clots," Alexandrov said in an interview with United Press International.

He cautioned, however, the pilot study was designed to test the safety not efficacy of the approach. "We did prove that ultrasou nd is safe when used in this way," he said. Dr. Gregory del Zoppo, of Scripps Research Institute in La Jolla, Calif., and a member of the American Stroke Association's executive committee told UPI ultrasound "has been looked at by a number of investigators. There is no doubt that sound waves can (break-up) clots, but safety is a concern."

While Alexandrov's study, which was designed as a safety trial, found no safety problems using the diagnostic ultrasound devices, del Zoppo said he doubts such low power devices actually improve the recanalization rate of clot-busting drugs. The temptation, he said, will be to use more powerful devices "and that's where safety becomes an issue."

He noted researchers in Germany and in Oregon tried putting ultrasound clot-busting probes on catheters that were guided to the clot site but those studies were halted when the sound waves not only dissolved the clots but also damaged artery walls.

Moreover, del Zoppo said the recanalization rates cited by Alexandrov are not especially high. But Alexandrov said his early results are so promising a new phase II study aimed at determining the most effective frequency has already begun. So far 30 patients have been treated and the goal is to enroll 120 patients.


'"/>




Related medicine news :

1. Ultrasound test may detect heart condition early
2. Ultrasound Screening Could Improve The Outcome Of Critically ill Patients
3. The Safety Of Prenatal Ultrasounds Questioned
4. Stanford Medical Center Implements The First Virtual Cardiac Ultrasound
5. Ultrasounds To Detect Changes In Heart Motions
6. Ultrasound may mean end to classic stethoscope
7. Optical Imaging Added To Ultrasound To Improve Imaging Of Breast Cancer
8. Three In One Ultrasound Probe For 3-D Imaging Of Heart And Tissue Destruction Developed
9. Fetal Development Face The Threat By Frequent Ultrasounds
10. Ultrasound Can Detect Breast Cancer in Pregnant Women
11. Ultrasound Helps Detecting Cancer In Pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton ... staged a mock evacuation of the facility as part of a disaster drill on ... Echo Hose EMS and Shelton City Emergency Manager, as well as the Connecticut ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network ... advocate for action towards gender equality at their inaugural Summit in New York City ... and reached a social audience of over 3 million. To watch the Mobilize Women ...
(Date:10/13/2017)... ... ... Talented host, actor Rob Lowe, is introducing a segment ... of "Success Files," which is an award-winning educational program broadcasted on PBS Member ... with passion and integrity. , Sciatica occurs when the sciatic nerve in the ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian ... On The Brink” is the creation of published author, William Nowers. Captain Nowers ... a WWII veteran, he spent thirty years in the Navy. Following his career ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest ... its plans to open a flagship location in Covington, LA at 401 N. U.S. ... Go store next to Office Depot in the Holiday Square shopping center. Its location ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... --  Montrium , an industry leader in powerful ... Trial Master Files & Inspection Readiness Conference ( ... Services has selected eTMF Connect to ... a leading European contract research organization (CRO), will ... enable greater collaboration with sponsors, improve compliance and ...
(Date:9/19/2017)... HistoSonics, Inc., a venture-backed medical device company developing a non-invasive, robotically assisted, platform ... leadership team developments today:   ... ... Tom Tefft ... Veteran medical device executive Josh Stopek , PhD, who has led ...
(Date:9/12/2017)... NEW YORK , Sept. 12, 2017   EcoVadis ... global supply chains, has published the first annual edition of its Global ... more than 20,400 companies evaluated by EcoVadis, based on Scorecard Ratings that ... ... Risk & Performance Index ...
Breaking Medicine Technology: