Navigation Links
Ultrasound helps stroke treatment

According to surgeons, they use sound waves to pulverize gallstones and now stroke experts are trying to determine if less powerful ultrasound can improve the efficacy of the clot-busting drugs used to restore blood flow to the brain.// Dr. Andrei Alexandrov, of the University of Texas, said he was using intracranial ultrasound to track the efficacy of the clot-busting drug called tPA or alteplase.

Shortly after initiating the ultrasound monitoring, emergency room nurses told him patients "were getting better really fast." At that point, he decided to initiate a pilot study to determine if ultrasound could boost the clot-busting or thrombolysis ability of tPA, he explained Friday during a news briefing at the 27th International Stroke Conference in San Antonio.

Alexandrov uses a hand-held ultrasound device fitted into a frame "like the frame inside a construction worker's hard hat," he said. Using a Food and Drug Administration-approved diagnostic frequency setting of 2 megahertz, the device focuses on the clot while the tPA is infused over a period of about an hour and then continues to track the clot for an hour after infusion.

Alexandrov said sound waves are very powerful and a low thumping "could mechanically shake apart a clot." But that approach would be dangerous because it would be difficult to control. The FDA approved diagnostic frequency is "faster but gentler. It creates micro-vibrations that work on the surface of the clot to open up more surface that the tPA can then bind to and penetrate," he said.

The pilot study enrolled 40 patients, average age 65. Thirty-seven percent had complete clearance of clots, called recanalization, within two hours of treatment initiation and "70 percent had a partial clearance of clots," Alexandrov said in an interview with United Press International.

He cautioned, however, the pilot study was designed to test the safety not efficacy of the approach. "We did prove that ultrasou nd is safe when used in this way," he said. Dr. Gregory del Zoppo, of Scripps Research Institute in La Jolla, Calif., and a member of the American Stroke Association's executive committee told UPI ultrasound "has been looked at by a number of investigators. There is no doubt that sound waves can (break-up) clots, but safety is a concern."

While Alexandrov's study, which was designed as a safety trial, found no safety problems using the diagnostic ultrasound devices, del Zoppo said he doubts such low power devices actually improve the recanalization rate of clot-busting drugs. The temptation, he said, will be to use more powerful devices "and that's where safety becomes an issue."

He noted researchers in Germany and in Oregon tried putting ultrasound clot-busting probes on catheters that were guided to the clot site but those studies were halted when the sound waves not only dissolved the clots but also damaged artery walls.

Moreover, del Zoppo said the recanalization rates cited by Alexandrov are not especially high. But Alexandrov said his early results are so promising a new phase II study aimed at determining the most effective frequency has already begun. So far 30 patients have been treated and the goal is to enroll 120 patients.


'"/>




Related medicine news :

1. Ultrasound test may detect heart condition early
2. Ultrasound Screening Could Improve The Outcome Of Critically ill Patients
3. The Safety Of Prenatal Ultrasounds Questioned
4. Stanford Medical Center Implements The First Virtual Cardiac Ultrasound
5. Ultrasounds To Detect Changes In Heart Motions
6. Ultrasound may mean end to classic stethoscope
7. Optical Imaging Added To Ultrasound To Improve Imaging Of Breast Cancer
8. Three In One Ultrasound Probe For 3-D Imaging Of Heart And Tissue Destruction Developed
9. Fetal Development Face The Threat By Frequent Ultrasounds
10. Ultrasound Can Detect Breast Cancer in Pregnant Women
11. Ultrasound Helps Detecting Cancer In Pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers ... companies have a waiver for care if the client has a cognitive impairment diagnosis. ... pays for care, is often waived, so the benefits from their insurance start immediately,” ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for professional ... action towards gender equality at their inaugural Summit in New York City in June. ... a social audience of over 3 million. To watch the Mobilize Women video, ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The ... the most popular and least understood books in the Holy Scriptures, Revelation. The Book ... have baffled scholars for centuries. Many have tossed it off as mere rubbish, but ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in ... awarded a contract by the Center for Medicare and Medicaid Services (CMS). The ... enterprise use of Agile methodologies in a consistent and high value manner across ...
(Date:10/13/2017)... ... , ... “America On The Brink”: the Christian history of the United States ... creation of published author, William Nowers. Captain Nowers and his wife, Millie, have ... thirty years in the Navy. Following his career as a naval aviator and ...
Breaking Medicine News(10 mins):
(Date:9/23/2017)... HORSHAM, Pa. , Sept. 22, 2017 ... received a complete response letter from the U.S. Food ... (BLA) seeking approval of sirukumab for the treatment of ... response letter indicates additional clinical data are needed to ... of moderately to severely active RA. ...
(Date:9/19/2017)... --  ZirMed Inc ., a recognized leader in cloud-based revenue ... been ranked #1 by its users for the seventh consecutive ... Survey. ZirMed was recognized as the top-ranked end-to-end revenue cycle ... over 200 beds and holds one of the longest #1 ... ...
(Date:9/12/2017)... and NEW YORK , Sept. 12, 2017 ... performance ratings for global supply chains, has published the first annual edition ... CSR performance of more than 20,400 companies evaluated by EcoVadis, based on ... 2015 and 2016. ... EcoVadis Global CSR Risk & Performance Index ...
Breaking Medicine Technology: