Navigation Links
Ultrasound helps stroke treatment

According to surgeons, they use sound waves to pulverize gallstones and now stroke experts are trying to determine if less powerful ultrasound can improve the efficacy of the clot-busting drugs used to restore blood flow to the brain.// Dr. Andrei Alexandrov, of the University of Texas, said he was using intracranial ultrasound to track the efficacy of the clot-busting drug called tPA or alteplase.

Shortly after initiating the ultrasound monitoring, emergency room nurses told him patients "were getting better really fast." At that point, he decided to initiate a pilot study to determine if ultrasound could boost the clot-busting or thrombolysis ability of tPA, he explained Friday during a news briefing at the 27th International Stroke Conference in San Antonio.

Alexandrov uses a hand-held ultrasound device fitted into a frame "like the frame inside a construction worker's hard hat," he said. Using a Food and Drug Administration-approved diagnostic frequency setting of 2 megahertz, the device focuses on the clot while the tPA is infused over a period of about an hour and then continues to track the clot for an hour after infusion.

Alexandrov said sound waves are very powerful and a low thumping "could mechanically shake apart a clot." But that approach would be dangerous because it would be difficult to control. The FDA approved diagnostic frequency is "faster but gentler. It creates micro-vibrations that work on the surface of the clot to open up more surface that the tPA can then bind to and penetrate," he said.

The pilot study enrolled 40 patients, average age 65. Thirty-seven percent had complete clearance of clots, called recanalization, within two hours of treatment initiation and "70 percent had a partial clearance of clots," Alexandrov said in an interview with United Press International.

He cautioned, however, the pilot study was designed to test the safety not efficacy of the approach. "We did prove that ultrasou nd is safe when used in this way," he said. Dr. Gregory del Zoppo, of Scripps Research Institute in La Jolla, Calif., and a member of the American Stroke Association's executive committee told UPI ultrasound "has been looked at by a number of investigators. There is no doubt that sound waves can (break-up) clots, but safety is a concern."

While Alexandrov's study, which was designed as a safety trial, found no safety problems using the diagnostic ultrasound devices, del Zoppo said he doubts such low power devices actually improve the recanalization rate of clot-busting drugs. The temptation, he said, will be to use more powerful devices "and that's where safety becomes an issue."

He noted researchers in Germany and in Oregon tried putting ultrasound clot-busting probes on catheters that were guided to the clot site but those studies were halted when the sound waves not only dissolved the clots but also damaged artery walls.

Moreover, del Zoppo said the recanalization rates cited by Alexandrov are not especially high. But Alexandrov said his early results are so promising a new phase II study aimed at determining the most effective frequency has already begun. So far 30 patients have been treated and the goal is to enroll 120 patients.


'"/>




Related medicine news :

1. Ultrasound test may detect heart condition early
2. Ultrasound Screening Could Improve The Outcome Of Critically ill Patients
3. The Safety Of Prenatal Ultrasounds Questioned
4. Stanford Medical Center Implements The First Virtual Cardiac Ultrasound
5. Ultrasounds To Detect Changes In Heart Motions
6. Ultrasound may mean end to classic stethoscope
7. Optical Imaging Added To Ultrasound To Improve Imaging Of Breast Cancer
8. Three In One Ultrasound Probe For 3-D Imaging Of Heart And Tissue Destruction Developed
9. Fetal Development Face The Threat By Frequent Ultrasounds
10. Ultrasound Can Detect Breast Cancer in Pregnant Women
11. Ultrasound Helps Detecting Cancer In Pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/24/2016)... ... May 24, 2016 , ... The old expression “a ... problem. A common injury that’s often misunderstood, whiplash should be swiftly diagnosed and treated ... orthopedic spine surgeon at Atlantic Spine Center . , So named because ...
(Date:5/24/2016)... ... 24, 2016 , ... Researchers from Catholic Health Initiatives (CHI) ... bleeding complications from percutaneous coronary intervention (PCI). The data, presented at the annual ... document a 40% reduction in risk-adjusted bleeding event rates over a two-year period ...
(Date:5/24/2016)... ... May 24, 2016 , ... ... web-based software module. The cutting-edge feature provides end users with an embedded, ... self-service business intelligence solution and its analytics engine. , This powerful ...
(Date:5/23/2016)... Akron, Ohio (PRWEB) , ... May 23, 2016 ... ... not-for-profit continuing care retirement community, dedicated its new $11.5 million, 64-room assisted living ... an invitation-only ceremony and ribbon cutting. , The new building provides the ...
(Date:5/23/2016)... ... May 23, 2016 , ... According to an article ... than 1% of United Kingdom residents who could benefit from bariatric surgery are actually ... increases the number of bariatric procedures it offers to obese patients from 6,000 to ...
Breaking Medicine News(10 mins):
(Date:5/19/2016)... 19, 2016 A new report ... Market -Opportunities and Forecasts, 2015 -2022, projects that the ... 2022, registering a CAGR of 5.1% from 2015 to ... be the highest revenue-generating segment throughout the forecast period. ... one-third of the market share in 2015, and is ...
(Date:5/19/2016)... -- The equities market is never short of ... is without doubt the Healthcare space. ActiveWallSt.com has uncovered four ... Alkermes PLC (NASDAQ: ALKS ), AMAG Pharmaceuticals Inc. ... IDXX ), and Atossa Genetics Inc. (NASDAQ: ... http://www.activewallst.com/ On Wednesday, Alkermes PLC,s ...
(Date:5/19/2016)... 19, 2016 MGB Biopharma, ... of Anti-infectives, Welcomes the Final Instalment of Lord ... Today   Lord Jim O,Neill,s ... final recommendations, providing a comprehensive action plan for ... the rising threat of superbugs - something that ...
Breaking Medicine Technology: