Navigation Links
Ultimate Destination of anti-depressant, Prozac

Anti-depressant Prozac’s journey in the brain and its ultimate destination, has caught the interest of researchers at Cold Spring Harbor Laboratory on Long Island. //This finding will open doors for enabling better treatments for depression that will have relatively lesser side effects.

The findings also lay the foundation for many studies of the factors that control how, when, and where new neurons are generated from stem cells in the brain. Such work could eventually lead to cell replacement therapies for neurodegenerative and other brain disorders including Alzheimer’s and Parkinson’s disease.

It has been known for some years that Prozac (fluoxetine) is likely to relieve the symptoms of depression by somehow causing more neurons to be present in a particular region of the brain (the “dentate gyrus”). But the origins of these neurons, and how Prozac promotes their existence, have been a mystery until now.

By profiling the telltale marker proteins produced by different kinds of cells in the brains of adult mice, the researchers first defined discrete steps in the complex process, called neurogenesis, that converts unspecialized stem cells into mature, specialized neurons.

Next, knowing that Prozac treatment somehow increases the number of neurons in the brain, the researchers tested which step in the neurogenesis pathway might be stimulated by Prozac. They found that Prozac treatment specifically stimulates the generation of a kind of cells they dubbed “amplifying neural progenitors” or ANPs--the second step in the neurogenesis pathway from stem cells to mature neurons. (Illustration available on request)

The study is published in the published in the Proceedings of the National Academy of Sciences (advance on-line this week, in print on May 23). It was led by Grigori Enikolopov and spearheaded by postdoctoral fellow Juan Manuel Encinas. To address the controversy surrounding the use of Prozac in children and in pr egnant women, Enikolopov’s group is currently testing the effects of the drug on brain neurogenesis in juvenile and pregnant mice. The results of those experiments may provide valuable information for assessing the possible effects of Prozac and related drugs on fetal and adolescent brain development.

The researchers are currently using the approach and tools they’ve developed to explore whether other treatments for depression--including other drugs and deep brain stimulation--act in the same way as Prozac or in different ways. In addition, the scientists are screening for new drugs that expand the production of brain neurons by stimulating ANP cells to multiply.

Source: Newswise


'"/>




Related medicine news :

1. Indian Hospitals – A Destination For Quality Medical Care
2. India - Favored Orthopedics Surgery Destination
3. Flu Vaccine’s Destination Changed From Illinois To Pakistan
4. Growth Factors Help Neurons to Reach Their Correct Destination
5. Skin Cells Make Use of Geographic Co-Ordinates to Reach Their Destination
6. India, a Hot Destination? Software or Sex, Indians are the Best!
7. India to Be Made Medical and Health Tourism Destination
8. Prozac miracle could end in disaster
9. Drug Prozac was found to control anger in post-stroke patients
10. Prozac Unplugged
11. Prozac Gets Conditional Clearance For Treating Children
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/8/2016)... ... 2016 , ... The Valentine’s Season is famous for gift giving with flowers, chocolates and other ... loved. This year, for more than 5.6 million Americans suffering with Alzheimer’s, those store ... to remind them of the lives they’ve led and the people they’ve touched. ...
(Date:2/8/2016)... ... 08, 2016 , ... Tingley Rubber Corporation , a ... its range of unique and advantaged protective solutions to a growing and ... bilingual customer service and marketing support. A new distribution center in Brampton, Ontario ...
(Date:2/8/2016)... ... February 08, 2016 , ... Delta Dental of California ... combat pancreatic cancer. , Gary D. Radine, who recently retired as president and CEO ... Cancer Society’s 2015 CEO of the Year , helped lead the effort to ...
(Date:2/8/2016)... , ... February 08, 2016 , ... ... wide variety of organizations. DocuSyst provides a cloud hosted environment for FileHold ... installations include integration with various 3rd party applications using the FileHold web services ...
(Date:2/8/2016)... , ... February 08, 2016 , ... TopConsumerReviews.com recently awarded ... Mole removal products. , Moles are derived from a cluster of melanin when exposed ... the wrong places and create a lifetime of embarrassment. Historically, mole removal ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... CITY, Calif., Feb. 8, 2016  Aoxing Pharmaceutical Company, Inc. (NYSE ... fiscal year 2016, ended December 31, 2015, the Company achieved ... recorded in the same quarter in fiscal 2015. ... in Q2 of fiscal year 2016 was $2,068,635, or $.03 ... or $.01 per share, in the Q2 of fiscal year ...
(Date:2/8/2016)... Feb. 8, 2016 ... of the "Label-Free Detection Market by ... 2020" report to their offering. ... addition of the "Label-Free Detection Market ... to 2020" report to their offering. ...
(Date:2/8/2016)...  HemaFlo Therapeutics, Inc. announced today that the United States ... 9,119,880 covering the use of NephroFlow to treat acute kidney ... founder, said, "We are pleased to secure our rights to ... , PhD, HemaFlo,s founder, said, "We are pleased to secure ... Dale Peterson , PhD, HemaFlo,s founder, said, "We ...
Breaking Medicine Technology: