Navigation Links
UK Scientists to Reveal Genetic Secrets Behind Serious Illnesses

A team of UK scientists have undertaken what is described as the biggest DNA analysis of whole human genomes.//

Their findings will mark the biggest single leap in the understanding of how genes dictate our propensity to get ill, opening the door to a new wave of tailored therapies and tests to predict the likelihood that people will develop a serious illness.

A coalition of 50 groups, including 24 leading human geneticists, has completed a study which in the course of the next year will reveal genetic signposts for heart disease, diabetes, bipolar disorder and hypertension.

Over the coming months, the consortium will release similarly detailed findings in major journals for eight common illnesses. The researchers have analysed 19,000 DNA samples, which include 2,000 for people who suffer from each of the diseases and a control group of 3,000.

Separately, they are examining 15,000 markers for genetic variations relating to another four diseases - breast cancer, autoimmune thyroid disease, multiple sclerosis, and ankylosing spondylitis, a chronic swelling of the joints.

Cardiff psychiatrists taking part will reveal genetic variations which dictate the probability a person will develop bipolar disorder. "The genes will tell us which biological systems are involved and allow us to predict who is at risk," said Nick Craddock, leading the bipolar disorder research.

Mark Walport, director of the Wellcome Trust in the UK, which sponsors the programme, said: "This is the first time that anyone has been able to look at genetic variations at this scale - results for some other diseases are as important as those for obesity."

Genetic tests are currently available for specific genetic disorders, but the Wellcome Trust Case Control Consortium is looking at the more mild and multiple genetic variations which combine with environmental factors to give a person an increased risk of developing a disease.

Earlier this week Exeter and Oxford Universities revealed a genetic variation responsible for obesity carried by one in six people.

Those carrying one copy of the "fat" FTO gene had a 30 per cent increased risk of being obese compared to a person with no copies of that version, scientists found.

Those carrying two copies of the variant had a 70% increased risk of being obese, and were on average three kilos heavier than a similar person with no copies.

Peter Donnelly, Wellcome Trust consortium chair, said: "We are trying to identify the genetic factors which make some people more likely to develop a disease than others. We know genetics play a part but we haven't found the parts of the genome involved."

However, some scientists have pointed out that there are other, as yet undiscovered, genes involved in obesity, casting doubt on the usefulness of a test aimed at FTO alone.

Obesity is a complex disorder and there is no evidence from this research to suggest that carriers of the gene will not successfully lose weight by decreasing their energy intake and becoming more active, they have said.

They have further warned that genetic testing could be problematic where genes are identified before therapies exist, meaning that people could be told that they have a risk of developing an illness, but with no options to treat it.

There are also fears that testing will fuel the fledgling commercial market for genetic testing and that people will not receive the counselling required to react to a positive result for an illness. /V
'"/>




Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/20/2017)... ... June 20, 2017 , ... Many RNA ... regulatory principles, the research team developed expressRNA, a web platform encompassing computational tools ... reveals at nucleotide resolution the ‘RNA maps’, which demonstrate that RBPs bind to ...
(Date:6/20/2017)... ... 2017 , ... Uniform Advantage (UA), a multi-channel retailer of medical ... create tailored looks and athleisure-inspired outfits. UA Flex fabric is breathable, wrinkle resistant and ... With trendy looks hitting the medical community, UA Flex is for the medical professional ...
(Date:6/20/2017)... ... June 20, 2017 , ... BrightStar Care Centerville/South Dayton, a ... the Joint Commission, which accredits and certifies nearly 21,000 healthcare organizations and programs ... a symbol of quality that reflects an organization’s commitment to meeting certain performance ...
(Date:6/20/2017)... ... 20, 2017 , ... Uniworld Boutique River Cruise Collection recently gave ... boutique ship, S.S. Joie de Vivre . What really sets this ship apart ... River and designed small enough to dock directly in Paris. With The Cruise Web’s ...
(Date:6/20/2017)... ... June 20, 2017 , ... International water ... The Sharon Kleyne Hour Power of Water, Global Climate Change and Your Health ... world’s water crisis and how it affects the human eyes. , According ...
Breaking Medicine News(10 mins):
(Date:5/30/2017)... Corp. (NASDAQ: DRIO), a leading global digital health company with mobile ... presenting at the 7th annual LD Micro Invitational on Tuesday, June ... of DarioHealth will be giving the presentation and meeting with investors. ... 7th, 2017 at the Luxe Sunset Bel Air Hotel and will ... About LD Micro LD Micro was founded ...
(Date:5/30/2017)... AVIV, Israel , May 30, 2017 ... stage pharmaceutical Company specializing in the development of ... will present a company overview at three upcoming ... The 7th Annual LD Micro Invitational: ... Date:                     ...
(Date:5/26/2017)... International plc (NASDAQ: ENDP ) announced today that ... Company in a fireside chat at Goldman Sachs, 38 th ... at 10:40 a.m. PT / 1:40 p.m. ET. The conference ... Palos Verdes, CA. A live webcast ... the Company,s website at http://www.endo.com/investors/overview . Participants should allow ...
Breaking Medicine Technology: