( be strongly linked with breast cancer....)UK Scientists Identify Gene Mutations That Trigger Breast Cancer,Health

be strongly linked with breast cancer. Small variations in four genes emerged as the most likely associations. "We're very excited by these results because the regions we identified don't contain previously known inherited cancer genes," Professor Easton said.

"This opens the door to new research directions. Only very recent advances in technology have allowed us to carry out such a large comparison study," he said. Already, the scientists are applying the same approach to other cancers, such as prostate, lung and bowel cancers, in the hope of identifying genetic changes that can trigger a higher risk of developing any of the diseases.

Breast cancer is one of the most common forms of cancer in British women with some 44,000 new cases diagnosed each year. Inherited forms of breast cancer that are known to run in families account for between 5 and 10 per cent of cases. These genes - called BRCA1 and BRCA2 - were the first to be identified in the mid-1990s. Two of the four new genes are relatively common. For instance, between one in six and one in 16 women are estimated to carry two faulty copies of one of these genes.

The three other genes identified in the study are also common among the population but carry a lower risk of disease, said Cancer Research UK, which helped to fund the study. Professor Bruce Ponder, one of the leaders of the study and director of Cancer Research UK's Cambridge research institute, said that the new technique has greatly accelerated the rate at which cancer genes can be found.

"We have been able to search two thirds of the genome in one go. Rather than fish for new genes one at time with a rod and line, we have trawled the pool," Professor Ponder said. "At the moment we don't know how these genes interact with each other or with lifestyle factors, each of which might increase the risk," he said.

"We'll continue to search for more genes, but we'll also focus on unravell
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