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UK Reports Psychiatric Reactions to Weight-loss Drug Rimonabant

Even as the European Medicines Agency (EMEA) warned patients on anti-depressants against taking weight loss drug rimonabant, the Department of Health's Medicines and Healthcare products Regulatory Agency (MHRA) in UK said it had received reports of psychiatric reactions to drug, marketed as Acomplia.

"Three hundred and sixty-four (364) psychiatric reactions have been reported," it said. "Amongst these, there have been 48 reports of depression, 16 reports of suicidal thoughts and one report of self-injury."

It said evidence suggested one in 10 people who take Acomplia may develop psychiatric side effects.

"Approximately one patient in every 100 may experience suicidal thoughts."

About 41,000 patients in the UK have been treated with rimonabant since it was launched there in June 2006. Acomplia is manufactured by Sanofi-aventis, worlds fourth largest drug-makers.

The drug is being appraised by the National Institute for Health and Clinical Excellence (Nice) for use on the NHS.

However, it already has a European licence, meaning GPs can prescribe it to patients while they wait for final guidance from Nice.

Rimonabant targets a natural body system that governs a host of factors controlling appetite, weight, metabolism and energy use. It also works to combat the craving for nicotine, and was launched at a cost of 55.20 per patient per month.

In trials involving more than 6,000 patients in the US and Europe, around a quarter of those taking rimonabant lost more than 10 per cent of their initial body weight after a year. About half lost more than five per cent of their body weight.

Waist circumference, seen by many experts as a more important measurement, dropped by between 6cm-7cm.

One in five adults in the UK - almost 10 million people - is clinically obese.

The EMEA has said doctors in the European Union had been warned "of the risk of psychiatric
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