Navigation Links
UCLA Researchers Transform Stem cells From Fat tissues Into Smooth Muscle

Researchers from the David Geffen School of Medicine and the Henry Samueli School of Engineering and Applied Science at UCLA have announced today to have successfully// transformed adult stem cells taken from human adipose, or fat tissue into smooth muscle cells, which help the normal function of a large number of organs like the intestine, bladder and arteries.

The researchers announced that their study might help lead to the use of fat stem cells for smooth muscle tissue engineering and repair. The study had been reported in the July 24 online edition of the ‘Proceedings of the National Academy of Sciences’, and is one of the first studies in showing that stem cells derived from adipose tissue could be changed to attain the physical and biochemical characteristics and the functionality of a smooth muscle cells.

Smooth muscle cells are found within the human body in the walls of hollow organs like blood vessels, bladder, and intestines and contract and expand to help transport blood, urine, and waste through the body's systems.

"Fat tissue may prove a reliable source of smooth muscle cells that we can use to regenerate and repair damaged organs," said Dr. Larissa V. Rodriguez,principal investigator and assistant professor, Department of Urology, David Geffen School of Medicine at UCLA.

Rodriguez and her team first cultured the adipose-derived stem cells in a growth factor cocktail that encouraged the cells to transform into smooth muscle cells. Researchers observed the genetic expression and development of proteins, which are specific to this type of cell. So it looked like a smooth muscle cell, but would it act like one?

The next step required testing functionality to see if the cells would expand and contract like smooth muscle tissue. Rodriguez turned to associate professor of bioengineering Dr. Benjamin Wu at the UCLA Henry Samueli School of Engineering and Applied Science for help.

Wu's t eam developed a special device to evaluate the cells' ability to contract by tracking movement of micro beads dispersed in a collagen gel embedded with the cells. Researchers added different pharmacologic agents known to cause contraction or relaxation in smooth muscle.

"We found that the cells did indeed function just like smooth muscle," said Wu. "The new device allowed us to evaluate drug-induced changes in the physical properties of smooth muscle at the cell level – previously we've needed tissue samples to observe this phenomena."

To make sure they could reproduce the smooth muscle cells and to confirm the transformation, Rodriguez and her team cloned one of the primitive stem cells from the adipose tissue and repeated the experiments on a cloned population of cells with similar results.

”We wanted to make sure it wasn't an isolated case or particular conditions in the cell cultures that allowed us to create or select out already existing smooth muscle cells," said Rodriguez, also a member of the UCLA Stem Cell Institute. "We are surprised and pleased with the results and are excited about future applications.” Rodriguez notes the many advantages of using a patient's own fat stem cells for organ re-growth and tissue regeneration, including no need for anti-rejection medications. In patients with a diseased or absent organ, who cannot use their own organ tissue for regeneration, adipose stem cells offer an alternative.

Smooth muscle cells have also been produced from stem cells found in the brain and bone marrow, but acquiring stem cells from adipose tissue is much easier and most patients have adipose tissue readily available, according to Rodriguez. The next step, she adds, involves identifying and developing the growth factors that will induce transformation of cells more quickly. She is also starting to use smooth muscle cells for tissue engineering in the urinary tract, including the urethra.

Sourc e: EurekAlrt

Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:

(Date:10/13/2017)... ... 13, 2017 , ... The American Board of Family Medicine's (ABFM) Board of ... Executive Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. Newton will serve ... Puffer’s retirement at the end of 2018. Upon assuming the role of President and ...
(Date:10/13/2017)... ... ... Apple Rehab Shelton Lakes , which specializes in the delivery of sub-acute ... of a disaster drill on October 3rd. , Apple Rehab participated with the Shelton ... well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). The LTC-MAP ...
(Date:10/13/2017)... ... 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, ... and least understood books in the Holy Scriptures, Revelation. The Book of Revelation paints ... for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins says ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance ... management, will showcase a range of technology and learning solutions at the 68th ... and Expo to be held October 14–18, 2017 at the Mandalay Bay Resort ...
(Date:10/12/2017)... , ... October 12, 2017 , ... The American College ... to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in ... , In honor of Morris F. Collen, a pioneer in the field of medical ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017 Halo Labs announces the ... analysis system called the HORIZON at MIBio 2017 in ... subvisible and visible particulate matter in biopharmaceutical samples with unprecedented speed ... of the novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
(Date:9/27/2017)... Israel and NEW YORK , Sept. 27, ... with mobile health and big data solutions, today announced that its MyDario ... Please check your local TV listings for when The Dr. Oz Show ... ... season this month. ...
(Date:9/22/2017)... , Sept. 22, 2017 AVACEN Medical (AVACEN) ... is now successfully helping those with the widespread pain ... Fibromyalgia diagnosed Amanda in Essex, England ... washing my hair, experiencing no sleep at all, tremendous ... spasm… I cannot recommend [the AVACEN 100] enough, how ...
Breaking Medicine Technology: