Navigation Links
UCLA Researchers Transform Stem cells From Fat tissues Into Smooth Muscle

Researchers from the David Geffen School of Medicine and the Henry Samueli School of Engineering and Applied Science at UCLA have announced today to have successfully// transformed adult stem cells taken from human adipose, or fat tissue into smooth muscle cells, which help the normal function of a large number of organs like the intestine, bladder and arteries.

The researchers announced that their study might help lead to the use of fat stem cells for smooth muscle tissue engineering and repair. The study had been reported in the July 24 online edition of the ‘Proceedings of the National Academy of Sciences’, and is one of the first studies in showing that stem cells derived from adipose tissue could be changed to attain the physical and biochemical characteristics and the functionality of a smooth muscle cells.

Smooth muscle cells are found within the human body in the walls of hollow organs like blood vessels, bladder, and intestines and contract and expand to help transport blood, urine, and waste through the body's systems.

"Fat tissue may prove a reliable source of smooth muscle cells that we can use to regenerate and repair damaged organs," said Dr. Larissa V. Rodriguez,principal investigator and assistant professor, Department of Urology, David Geffen School of Medicine at UCLA.

Rodriguez and her team first cultured the adipose-derived stem cells in a growth factor cocktail that encouraged the cells to transform into smooth muscle cells. Researchers observed the genetic expression and development of proteins, which are specific to this type of cell. So it looked like a smooth muscle cell, but would it act like one?

The next step required testing functionality to see if the cells would expand and contract like smooth muscle tissue. Rodriguez turned to associate professor of bioengineering Dr. Benjamin Wu at the UCLA Henry Samueli School of Engineering and Applied Science for help.

Wu's t eam developed a special device to evaluate the cells' ability to contract by tracking movement of micro beads dispersed in a collagen gel embedded with the cells. Researchers added different pharmacologic agents known to cause contraction or relaxation in smooth muscle.

"We found that the cells did indeed function just like smooth muscle," said Wu. "The new device allowed us to evaluate drug-induced changes in the physical properties of smooth muscle at the cell level – previously we've needed tissue samples to observe this phenomena."

To make sure they could reproduce the smooth muscle cells and to confirm the transformation, Rodriguez and her team cloned one of the primitive stem cells from the adipose tissue and repeated the experiments on a cloned population of cells with similar results.

”We wanted to make sure it wasn't an isolated case or particular conditions in the cell cultures that allowed us to create or select out already existing smooth muscle cells," said Rodriguez, also a member of the UCLA Stem Cell Institute. "We are surprised and pleased with the results and are excited about future applications.” Rodriguez notes the many advantages of using a patient's own fat stem cells for organ re-growth and tissue regeneration, including no need for anti-rejection medications. In patients with a diseased or absent organ, who cannot use their own organ tissue for regeneration, adipose stem cells offer an alternative.

Smooth muscle cells have also been produced from stem cells found in the brain and bone marrow, but acquiring stem cells from adipose tissue is much easier and most patients have adipose tissue readily available, according to Rodriguez. The next step, she adds, involves identifying and developing the growth factors that will induce transformation of cells more quickly. She is also starting to use smooth muscle cells for tissue engineering in the urinary tract, including the urethra.

Sourc e: EurekAlrt
'"/>




Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/20/2017)... ... ... The StayWell Company and VUCA Health announced today that ... behavior change and improve health literacy among patients. VUCA Health, which created and manages ... video capability at StayWell booth 3443 during HiMSS. , The VUCA library has ...
(Date:2/20/2017)... TX (PRWEB) , ... February 20, 2017 , ... ... is now offering a full range of emergency dental care at his office, ... and gums. When patients experience dental emergencies, they are at risk for serious ...
(Date:2/19/2017)... ... February 19, 2017 , ... The Citadel’s new Swain Department of Nursing ... by Amelia Joseph, Ph.D. Joseph was engaged by the college as a consultant to ... early 2016. After a nation-wide search, she was selected to head the department as ...
(Date:2/18/2017)... ... February 17, 2017 , ... ... **FDAnews Free Webinar**, March 1, 2017 — 1:30 p.m. – 2:30 p.m. ... burden? Pay dividends in enhanced and predictable product performance? Streamline processes resulting ...
(Date:2/18/2017)... ... February 18, 2017 , ... ... Pixel Film Studios ’ ProParagraph Fashion Volume 2 for all multi-line FCPX ... applications. Users can pick and choose from hand-crafted trend-setting designs with smooth ...
Breaking Medicine News(10 mins):
(Date:2/20/2017)... , Feb. 20, 2017   Orion Health ... its Amadeus precision medicine platform to the ... currently manages over 110 million patient records globally. ... developing cloud-based, big data solutions built on modern, scalable ... Healthcare and Life Sciences. "The AWS Cloud gives healthcare ...
(Date:2/20/2017)... , Feb. 20, 2017 Research and Markets ... and Freezer Market Analysis and Trends - Product (RFID refrigerators and ... to 2025" report to their offering. ... The Global RFID Blood Refrigerator and ... 21.3% from 2015 to 2025. This industry report ...
(Date:2/20/2017)... Feb. 20, 2017   Alberty   ... Batavia, NY has announced a significant shift ... and wellness programs to servicing local Veteran Affairs Centers ... budgets and an increased need to secure cost effective ... to source locally for their goods & services. ...
Breaking Medicine Technology: