Navigation Links
UCI Scientists Reconstruct Migration of Avian Flu Virus

UC Irvine researchers have combined genetic and geographic data of the H5N1 avian flu virus to reconstruct its history over the past decade. //They found that multiple strains of the virus originated in the Chinese province of Guangdong, and they identified many of the migration routes through which the strains spread regionally and internationally.

By knowing where H5N1 strains develop and migrate, health officials can better limit the spread of the virus by strategically intervening. Local vaccinations can be better administered by using strains from regions that have repeatedly contributed to infections.

"If you can control the virus at its source, you can control it more efficiently," said Walter Fitch, professor of ecology and evolutionary biology in the School of Biological Sciences at UCI and co-author of the study. "With a road map of where the strain has migrated, you're more likely to isolate the strain that you should be using to make the vaccine."

The study appears this week in the online early edition of the Proceedings of the National Academy of Sciences.

This research offers the first statistical analysis detailing the geographic distribution of influenza A H5N1, the bird flu strain. While previous work informally identified H5N1 strains by location, the UCI analysis is the first to systematically track the migration of H5N1 through its evolutionary history, adding new details that identify the relative importance of the geographic and evolutionary advances the virus makes.

From 192 samples obtained across Eurasia, the UCI team reconstructed the virus's geographic reach and evolution. The analysis shows that Guangdong – home to a large poultry industry – is the source of many H5N1 strains that have spread to other provinces and countries. To the south in nearby Indochina, the strains appear largely limited to dispersal among local areas.

Genetic sequences the scientists analyzed suggest t hat parallel evolution of different H5N1 strains lets the virus infect and cycle through different host species in a region, regardless of the host or vector species it infects first. This way, the virus can find the right host to spread the infection to the next location. This parallel evolution – the independent evolution of similar traits – enables H5N1 to spread quickly, the scientists believe.

"The ability to develop the right mutation allows the virus to hop from one host type to the next," said Robert Wallace, UCI postdoctoral researcher and lead author of the study. "By spreading across a large area, the virus in essence can run multiple experiments in multiple locations, increasing the likelihood that it will mutate into a form that can be transmitted from human to human."

Avian flu has been isolated almost exclusively among bird populations. The H5N1 virus has only sporadically been passed on from a bird host to humans; there is little evidence that the virus can efficiently be passed on from human to human. Although fewer than 300 recorded human cases of this flu have been recorded worldwide, its high mortality rate raises concerns that if the virus mutates to where humans can pass it on, a flu pandemic may occur.

Source-Eurekalert
RM
'"/>




Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob ... sciatica in a new episode of "Success Files," which is an award-winning educational ... and investigates each subject in-depth with passion and integrity. , Sciatica occurs when ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and ... of published author, William Nowers. Captain Nowers and his wife, Millie, have six ... years in the Navy. Following his career as a naval aviator and carrier ...
(Date:10/12/2017)... ... , ... Planet Fitness, one of the largest and fastest growing franchisors and ... flagship location in Covington, LA at 401 N. U.S. Highway 190, in January of ... Depot in the Holiday Square shopping center. Its location allows it to serve both ...
(Date:10/12/2017)... ... ... The American College of Medical Informatics (ACMI) will present the 2017 Morris ... of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium is taking ... in the field of medical informatics, this prestigious award is presented to an individual ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa Mohebi, the ... medical article to the newly revamped Cosmetic Town journal section, featuring ... transplant procedure known as Follicular Unit Extraction (FUE). , Dr. Mohebi ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... -- The Rebound mobile app is poised to become a ... of prescription drug addiction. The app empowers users to develop ... down their dosage in a safe, controlled manner while maximizing ... first 100,000 people to sign up will enjoy 3 months ... ...
(Date:9/27/2017)... their devotion to personalized service, SMP Pharmacy Solutions announces their ... South Florida Business Journal,s 50 Fastest-Growing Companies, and listed for ... specialty pharmacy has found its niche.  To that end, the ... by SFBJ as the 2017 Power Leader in Health Care. ... award in October, Bardisa said of the three achievements, "It,s ...
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., a ... design, and immune-engineering today announced the launch of ... development of personalized therapeutic cancer vaccines. EpiVax has ... exclusive access to enabling technologies to the new ... will lead EpiVax Oncology as Chief Executive Officer. ...
Breaking Medicine Technology: