Navigation Links
UCI Scientists Reconstruct Migration of Avian Flu Virus

UC Irvine researchers have combined genetic and geographic data of the H5N1 avian flu virus to reconstruct its history over the past decade. //They found that multiple strains of the virus originated in the Chinese province of Guangdong, and they identified many of the migration routes through which the strains spread regionally and internationally.

By knowing where H5N1 strains develop and migrate, health officials can better limit the spread of the virus by strategically intervening. Local vaccinations can be better administered by using strains from regions that have repeatedly contributed to infections.

"If you can control the virus at its source, you can control it more efficiently," said Walter Fitch, professor of ecology and evolutionary biology in the School of Biological Sciences at UCI and co-author of the study. "With a road map of where the strain has migrated, you're more likely to isolate the strain that you should be using to make the vaccine."

The study appears this week in the online early edition of the Proceedings of the National Academy of Sciences.

This research offers the first statistical analysis detailing the geographic distribution of influenza A H5N1, the bird flu strain. While previous work informally identified H5N1 strains by location, the UCI analysis is the first to systematically track the migration of H5N1 through its evolutionary history, adding new details that identify the relative importance of the geographic and evolutionary advances the virus makes.

From 192 samples obtained across Eurasia, the UCI team reconstructed the virus's geographic reach and evolution. The analysis shows that Guangdong – home to a large poultry industry – is the source of many H5N1 strains that have spread to other provinces and countries. To the south in nearby Indochina, the strains appear largely limited to dispersal among local areas.

Genetic sequences the scientists analyzed suggest t hat parallel evolution of different H5N1 strains lets the virus infect and cycle through different host species in a region, regardless of the host or vector species it infects first. This way, the virus can find the right host to spread the infection to the next location. This parallel evolution – the independent evolution of similar traits – enables H5N1 to spread quickly, the scientists believe.

"The ability to develop the right mutation allows the virus to hop from one host type to the next," said Robert Wallace, UCI postdoctoral researcher and lead author of the study. "By spreading across a large area, the virus in essence can run multiple experiments in multiple locations, increasing the likelihood that it will mutate into a form that can be transmitted from human to human."

Avian flu has been isolated almost exclusively among bird populations. The H5N1 virus has only sporadically been passed on from a bird host to humans; there is little evidence that the virus can efficiently be passed on from human to human. Although fewer than 300 recorded human cases of this flu have been recorded worldwide, its high mortality rate raises concerns that if the virus mutates to where humans can pass it on, a flu pandemic may occur.

Source-Eurekalert
RM
'"/>




Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/6/2016)... York (PRWEB) , ... May 06, 2016 , ... A wide variety of national pet ... Events Home, Garden and Safety Media Showcase Wednesday, May 18 from noon to 8 p.m. ... offers a sneak peek at new and established home, garden, outdoor and safety pet products ...
(Date:5/6/2016)... (PRWEB) , ... May 06, 2016 , ... Logically, spring ... other seasons, when the weather is too cold, dry or hot, water on the ... can actually absorb moisture from the surrounding air. There’s only one problem, according to ...
(Date:5/6/2016)... ... ... is a speaker, author, and life strategy coach who is spreading the message of his ... publisher Strategic Book Group and its subsidiary Publish on Demand Global (PODG). , ... needed a heart and double-lung transplant. From this came a life-changing transformation that led him ...
(Date:5/6/2016)... ... ... Hawkins, Pastor and Overseer at The House of Yahweh, has written a new article this ... about helping to stop cancer. Yisrayl says there are too many suffering and dying from ... science industries will pay close attention and take action. The Pastor says that the root ...
(Date:5/6/2016)... ... May 06, 2016 , ... Kenneth Cochran, DSc, RN, FACHE, ... of the South announced today that Dr. Robert Menuet, Interventional Cardiologist with Cardiovascular ... Ultrasound Guided Coronary Atherectomy. , This procedure involves the removal of ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... 3, 2016   BIOTRONIK , a leader ... Food and Drug Administration (FDA) approval of Iperia ... heart failure patients with access to diagnostic magnetic ... remote monitoring with daily automatic transmission and closed ... in response to physiological demands. ...
(Date:5/3/2016)... , May 3, 2016   BIOTRONIK will ... extending care beyond the implant at the Heart Rhythm ... in San Francisco . ... the highest quality of patient care and satisfaction possible. ... for each and every tomorrow," said Marlou Janssen ...
(Date:5/3/2016)... , May 3, 2016 Pharmaceutical ... $55 million to a woman who says its talc-based ... awarded Gloria Ristesund $5 million in compensatory ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ... against the company. In February, the same court awarded ...
Breaking Medicine Technology: