Navigation Links
Type 1 Diabetes Linked to Stimuli from Nervous System

It has been attested by all medical researchers that type I diabetes is caused due to breakdown in the immune system of the body.// The flawed response from the immune system was understood to be the reason behind the damage caused to islet cells in the pancreas where insulin is produced.

A recent research conducted by Canadian scientists suggests that apart from immune system, the central nervous system also plays a key role in the development of Type 1 diabetes. Statistics show that200, 000 Canadians are estimated to suffer from diabetes. This disease may result in grave complications, including loss of vision, cardiovascular complications, amputation of limbs and kidney failure. In the studied done, laboratory mice were used that were already susceptible to Type 1 diabetes. The researchers discovered that there is a perceptible link between islet cells of pancreas, and the associated nerves that sense pain and other stimuli assonated with trauma. The researchers at the Hospital for Sick Children and the University of Calgary have postulated that without this control system normal function of islet cells cannot thrive. Dr. Michael Dosch,the lead researcher is an immunologist at Sick Kids Hospital. He explained that their findings reveal a closer link between sensory nerves and immune system than they had known existed earlier.

They were really surprised to watch the effect of merely “knocking” off a few pain related sensory nerve cells. Called “substance P”, these cells are capable of amplifying pain or trigger an inflammatory process. None of the mice, in which the substance p was knocked off developed diabetes. Neither did their pancreas show any sign of inflammation.

The researchers have inferred that a malfunctioning immune system is not the only culprit responsible for triggering of Type 1 Diabetes. The nerve cells responding to pain also play a key role.

However the scientists were quite puzzled to note that injecting substance P into mice that had inflamed pancreas also reversed the process of inflammation.

The team of researchers now plans to continue their studies using human subjects with a strong family history of Type 1 diabetes in order to look for abnormalities in levels of sensitivity to pain, which could be a harbinger of tendency to develop the disease.

Diabetics often complain of peripheral neuropathy, a disorder characterized by numbness of extremities described by patients as “pins and needles” or burning. This disorder could be the result of the nervous system’s role in the development of the disease, postulated the researchers.

Since the tests are not toxic, clinical trials may soon be initiated once the effect of Substance P is studied on human beings said the researchers.

This research holds promise in timely detection of onset of diabetes, Type 1,which may help in nipping the illness in the bud.



<
'"/>




Related medicine news :

1. Is Diabetes the Leading Cause of Kidney Failure in India
2. Diabetes and Depression often go hand-in-hand
3. Thirty minutes of work up per day reduces the risk of Diabetes
4. Diabetes on the rise
5. Irregular Periods Linked to Diabetes
6. Cinnamon combats Diabetes
7. Good News For Women With Gestational Diabetes
8. Processed Meat, Diabetes connection Found
9. Pancreatic Cancer may be linked to Diabetes
10. Gestational Diabetes linked to Chromosomal defici
11. A way to slow the progression of Type 1 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/5/2016)... ... December 05, 2016 , ... Sabah Shah MD, MBA has joined the Retina ... of New York was founded by James M. Maisel, MD and has been providing tertiary ... has always followed a legacy of surpassing expectations amongst her peers. Growing up in ...
(Date:12/5/2016)... ... December 05, 2016 , ... ... Surgical Facial Rejuvenation" at the 2016 Anti-Aging & Beauty Awards at The ... The Aesthetic & Anti-aging Medicine European Congress (AMEC) brings together the industry’s ...
(Date:12/4/2016)... ... December 03, 2016 , ... The Lymphoma Research Foundation (LRF) ... and serving the lymphoma community through a comprehensive series of education programs, outreach ... in New York City, with long-time partners The Paul Foundation, on November 10, ...
(Date:12/4/2016)... ... 03, 2016 , ... Penrose Senior Care Auditors® was announced ... evening at the 26th Annual SMU Cox Dallas 100™ Awards Ceremony and Banquet ... for Entrepreneurship. Dallas 100™, co-founded by the Caruth Institute, honors the ingenuity, commitment ...
(Date:12/4/2016)... ... December 04, 2016 , ... Responsible dental care hinges on regular brushing of ... optimal results. This important necessity inspired an inventor from Las Vegas, Nev., to design ... that people break or avoid bad techniques of brushing the teeth in order to ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... Israel , December 5, 2016 ... identifying, in-licensing and developing promising therapeutic candidates, presents positive Phase ... BL-8040, the Company,s leading oncology platform at the ongoing 58th ... San Diego, California . ... , , ...
(Date:12/5/2016)... Taiwan , Dec. 5, 2016 ... non-inferiority to hydroxyurea (HU) in Complete Hematologic Response (CHR) ... profile of ropeginterferon alfa-2b versus HU AOP ... follow-up trial CONTINUATION-PV to obtain European marketing authorization in the ... data to the FDA as it seeks approval for commercialization ...
(Date:12/4/2016)... --  Pairnomix, LLC, a genetic research company and member ... White House, today announced that findings from its first case ... therapies for a patient with epileptic encephalopathy caused by a ... the 70 th Annual Meeting of the American ... December 2-6, 2016.  Pairnomix, unique process involves creating ...
Breaking Medicine Technology: