Navigation Links
Two in One Cell Offers Hope to Find a Cure for Cancer

The international team of researchers from the United States and France has discovered a mouse immune cell that functions as both assassin and messenger. This led to the // race among scientists to find a human equivalent of this multitasking cell. Cells that could seek out and destroy cancer have to be designed.

Drew Pardoll, M.D., Ph.D., the Seraph Professor of Oncology at the Johns Hopkins Kimmel Cancer Center says that this cell has the ability to kill foreign pathogens and distribute information about that experience. He said that the cell speeds up the immune reactions and makes the system more efficient in removing the foreign material. The results were published in the journal Nature Medicine.

Frank Housseau, Ph.D., research associate at Hopkins' Kimmel Cancer Center and member of Pardoll's immunology laboratory said that Interferon-producing killer dendritic cell (IKDC) which is very rare and is seen in the spleen also has similar features. Immune system works through cross linking and signaling among a variety of cells. One of the first immune cells that alert the immune system is a natural killer (NK) cell. NK cells poke holes in the invader's outer membrane. Then, NK cells inform the other immune cells, including dendritic cells. Dendritic cells spread information about the foreign invaders to other immune cells, but do not actually kill the invaders.

Housseau said that the outer membranes of the dendritic cells were studded with NK cells. This resulted in a NK-dendritic cell blend. This is a new stage that retains all the molecular characteristics of both NK and dendritic cells. These were called the Interferon-producing killer dendritic cell (IKDC).

IKDC produces both types of interferon proteins, normally secreted independently by NK and dendritic cells. He also found both NK and dendritic like molecules on the surface of IKDCs. Initially these cells behave like NK cell. After the cell encounters a pathogen, t he cell switches roles from killer to dendritic like messenger. The cell sprouts long, hairy tentacles called dendrites. It uses its "arms" to increase the amount of surface area it reaches to communicate and interact with other immune cells. Then, the cell dies and is replenished by the bone marrow.

Researchers studied about these cells by fluorescent-tags and by infecting mice with bacteria called listeria. In assassin-mode, the IKDCs were found in the blood, lining of the gut, liver and other organs which were in close contact with the pathogen. In the lymph nodes they found approximately 35 % of the original group of IKDCs now secreting communication molecules signaling a switch to messenger-mode.

Housseau's colleagues in France, led by Laurence Zitvogel at the Institut Gustave Roussy, tested IKDCs in killing cancer cells. They injected mice with a cancer drug called Gleevec. This blocks an abnormal protein produced by cancer cells, and a growth factor for NK cells. The drug-growth factor combo served as a lure, leading the IKDCs to tumors implanted in the mice. The results were that tumors shrunk in mice, which received injections of IKDCs, but not in those receiving conventional NK cells only. Housseau's group is conducting further studies to verify the role of IKDC cells in infection and cancer.


Related medicine news :

1. Pancreatitis: Minimially Invasive Procedure Offers Long-Term Pain Relief
2. Drug Offers Hope for Alzheimers disease
3. Drug Firm Offers to Donate Smallpox Vaccine
4. fMRI Offers Insight Into An Infants Brain
5. Gel Offers A More Targeted Approach
6. Umbilical Cord Blood Offers Hope For Patients Who Require Bone Marrow Transplants
7. Surgery Offers Better Treatment For Third Degree Piles
8. New Study Offers Hope For Balding Men
9. Gamma Knife Offers New Hope For Trigeminal Neuralgia Patients
10. Study Offers Insights Into Treatment Of Rheumatoid Arthritis
11. CPHA Offers HIV Information Packages To Canadian Football League Teams
Post Your Comments:

(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding ... of its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. ... James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of ... award to iHire in recognition of their exemplary accomplishments in worksite health promotion. , ... Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Those who have ... these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as ... Michigan, has released tools for healthy coping following a traumatic event. , Trauma sufferers ...
(Date:6/24/2016)... Texas (PRWEB) , ... June 24, 2016 , ... ... International Conference and Scientific Sessions in Dallas that it will receive two significant ... of the grants came as PHA marked its 25th anniversary by recognizing patients, ...
(Date:6/24/2016)... ... , ... Comfort Keepers® of San Diego, CA is excited to announce they ... to drive cancer patients to and from their cancer treatments. Comfort Keepers provides ... life and ongoing independence. Getting to and from medical treatments is one of ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Research and ... Market for Companion Diagnostic Tests" report to their offering. ... for Companion Diagnostics The World Market for ... personalized medicine diagnostics. Market analysis in the report includes the ... Market (In Vitro Diagnostic Kits) by Region (N. America, EU, ...
(Date:6/24/2016)... Tenn. , June 24, 2016  Arkis ... providing less invasive and more durable cerebrospinal fluid ... in funding.  The Series-A funding is led by ... Lighthouse Fund, and other private investors.  Arkis, new ... neurosurgical instrumentation and the market release of its ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... the "Pharmaceutical Excipients Market by Type (Organic Chemical ... Preservative), Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast ... The global pharmaceutical excipients ... 2021 at a CAGR of 6.1% in the forecast ...
Breaking Medicine Technology: