Navigation Links
Turmeric prevents rheumatoid arthritis: US study

Turmeric, the spice that flavours and gives its yellow colour to Indian curries, may hold promise for the prevention of both rheumatoid arthritis// and osteoporosis, says a US study.

An ancient spice, it has been used for centuries by practitioners of Ayurvedic medicine in India to treat inflammatory disorders.

Turmeric extract containing the ingredient curcumin is marketed widely in the Western world as a dietary supplement for the treatment and prevention of a variety of disorders, including arthritis.

At The University of Arizona College of Medicine, Janet L. Funk, MD, working with Barbara N. Timmermann, PhD, then-director of the Arizona Center for Phytomedicine Research, set out to determine whether and how turmeric works as an anti-arthritic.

They began by preparing their own extracts from the rhizome, or root, of the plant, providing themselves with well-characterised materials to test and to compare with commercially available products.

Funk and her colleagues then tested in animal models a whole extract of turmeric root, only the essential oils, and an oil-depleted extract containing the three major curcuminoids found in the rhizome.

Of the three extracts, the one containing the major curcuminoids was most similar in chemical composition to commercially available turmeric dietary supplements. It also was the most effective, completely inhibiting the onset of rheumatoid arthritis.

Funk, an endocrinologist in the UA Department of Medicine, says this study provides several noteworthy "firsts" according to an article in the American College of Rheumatology journal 'Arthritis and Rheumatism'.

Completed with the researchers' own prepared, well-defined extracts, the study represents the first documentation of the chemical composition of a curcumin-containing extract tested in a living organism, in vivo, for anti-arthritic efficacy.

It also provides the first evidence of anti-arthritic efficacy of a complex turmeric extract that is analogous in composition to turmeric dietary supplements.

The significance, she explains, is that translating the results of trials such as these to clinical use depends on accurate information about the chemical content and biological activity of the botanical supplements available for use.

This work paves the way for the pre-clinical and clinical trials needed before turmeric supplements can be recommended for medicinal use in preventing or suppressing rheumatoid arthritis.

This study also provides the first in vivo documentation of a mechanism of action - how curcumin-containing extracts protect against arthritis. The researchers found that the curcuminoid extract inhibits a transcription factor called NF-KB from being activated in the joint.

A transcription factor is a protein that controls when genes are switched on or off. Once the transcription factor NF-KB is activated, or turned on, it binds to genes and enhances production of inflammatory proteins, destructive to the joint.

The finding that curcuminoid extract inhibits activation of NF-KB suggests that turmeric dietary supplements share the same mechanism of action as anti-arthritic pharmaceuticals under development that target NF-KB.

It also suggests that turmeric may have a use in other inflammatory disorders, such as asthma, multiple sclerosis and inflammatory bowel disease.

In addition to preventing joint inflammation, Funk's study shows that the curcuminoid extract blocked the pathway that affects bone resorption.


Related medicine news :

1. Turmeric Found To Slow Down Melanoma Growth
2. Spread of Breast Cancer can be stopped by a component in Turmeric
3. Turmeric And Cabbage effective against prostate cancer
4. Turmeric and Onions-Weapons against Colon Cancer
5. Turmeric to prevent arthritis and osteoporosis
6. Turmeric in the Fight Against Prostate Cancer
7. Breast Feeding prevents obesity later on in life
8. Regular exercise prevents hip fractures
9. Gel prevents pregnancy
10. Staying mentally energitic prevents Alzheimers
11. Consuming fish prevents dementia risk
Post Your Comments:

(Date:11/26/2015)... ... November 26, 2015 , ... WorldCare ... participated in the 61st annual Employee Benefits Conference. The Employee Benefits Conference was ... November 8th through Wednesday, November 11th, 2015. The conference was held at the ...
(Date:11/26/2015)... ... November 26, 2015 , ... ... has collaborated with Women’s Web – an online resource for Indian women ... mental and emotional well-being relationship, life balance, stress, professional development, and lifestyle. ...
(Date:11/25/2015)... , ... November 25, 2015 , ... ... more aggressive than those found on mammography, according to a study published online ... additional cancers not seen on mammography may necessitate a change in treatment. , ...
(Date:11/25/2015)... ... November 25, 2015 , ... The holiday season ... and pleasing the palates of attendees is of the utmost importance. Whether you ... seasonal get-together, give these recipes a try this holiday season. , Turkey Croquettes ...
(Date:11/25/2015)... ... November 25, 2015 , ... Medical Solutions, one ... for its stellar workplace culture with the company’s Cincinnati office being named a ... Cincinnati office was named a finalist in Cincinnati Business Courier’s 13th annual Greater ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 2015 --> ... combineert immunotherapie met Bremachlorin-photodynamische therapie voor de ... ) --> ... ) Uit een ... (LUMC) blijkt dat ...
(Date:11/26/2015)... , November 26, 2015 ... addition of the "2016 Future Horizons ... of Abuse Testing Market: Supplier Shares, Country ... report to their offering. --> ... the "2016 Future Horizons and Growth ...
(Date:11/26/2015)... November 26, 2015 ... addition of the  "2016 Future Horizons ... Therapeutic Drug Monitoring (TDM) Market: Supplier ... Emerging Opportunities"  report to their offering.  ... announced the addition of the  "2016 ...
Breaking Medicine Technology: