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Tumour marker for detecting early Recurrence of Thyroid cancer may be soon available

thyroid,” Kloos says. “Some patients claimed that they'd rather die of their disease than go through that regularly.”

Hypothyroid state leads to fatigue, weight gain, constipation, mental dullness, lethargy, depression and other symptoms.

When thyroid cells are removed the Tg level comes to zero, however its presence later signals a possible return of the disease. Thyrogen, approved for use in 1998, allowed people to have a stimulated Tg test and continue taking the synthetic hormone.

The present study sought to help interpret the results of the Thyrogen-assisted Tg test. It involved 107 patients (88 women and 19 men; average age 36 years) treated for papillary, follicular or Hurthle cell thyroid cancer.

Following surgery and radioactive iodine treatment and the patients were injected with Thyrogen and tested for Tg levels between January 1999 and March 2001.

After an interval of three to five years, the researchers found recurrent tumors in about 80 percent of the patients with Tg levels above 2.0, and in about 2 percent of those with Tg levels below 0.5.

It is estimated 25,690 new cases of thyroid cancer will be detected in 2005, with 19,190 of those expected to occur in women. 1,490 people are expected to die of the disease.

Reference: Ernest L. Mazzaferri, OSU emeritus professor and chairman of medicine, was a co-author of the study.

Contact: Darrell E. Ward:Ward-15@medctr.osu.edu 614-293-3737, Ohio State niversity ,
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