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Tumor Blood Flow can Improve Chemotherapy

ff said. But much of this new vasculature is poorly constructed and leaks fluid into the spaces around the cancerous cells, increasing the pressure inside the tumor. This increased pressure outside the vasculature acts like a wall to prevent cancer drugs from passing through the blood vessels.

Bevacizumab eliminates the shoddy vasculature, temporarily sparing the more sturdily built vessels, which do not leak fluid, but deliver the drug throughout the tumor, Davidoff said.

Davidoffs team first treated mouse models that carried transplanted human neuroblastomas with a single dose of bevacizumab. They studied the changes in the tumor vasculature at different times after treatment with a single dose of bevacizumab; finally, they studied how well topotecan penetrated the tumor and inhibited its growth when given at different intervals after bevacizumab.

The researchers showed that bevacizumab reduced the density of the tumors vasculature to less than 30 percent of that in untreated tumors within seven days, accompanied by a significant decrease in pressure in the tumor caused by fluid passing through from the blood vessels.

The remaining, normalized vasculature perfused the tumor more thoroughly than before treatment with bevacizumab; and the amount of topotecan it carried throughout the tumor was about 80 percent more when given one to three days after bevacizumab compared to when both drugs were given either at the same time or seven days apart.

When the researchers administered topotecan to the tumor-bearing mice three days after bevacizumab, the size of the tumors was only 36 percent of the size of untreated tumors, compared to 88 percent when mice were treated with bevacizumab alone; 54 percent when treated with topotecan alone; and 44 percent when tumor-bearing mice were treated with both drugs at the same time.

We observed in the mouse model of neuroblastoma that t
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