A treatment for polycystic kidney disease(PKD), a leading cause of fatal kidney failure worldwide, has been identified by a research// team led by Yale biochemist Craig Crews, according to a report in the Proceedings of the National Academy of Sciences.
Over 12 million people worldwide suffer from PKD, a genetic disorder that causes uncontrolled growth of cells lining tubules in the kidneys, and results in the formation of many, large fluid-filled cysts in the kidneys.
“Unfortunately, aside from kidney transplantation, there has been no cure for PKD, nor has there been a suitable drug treatment to slow its progression,” said Crews, associate professor of chemistry, molecular, cellular & developmental biology and pharmacology. “We hope that is about to change,” he said.
The mesh of Traditional Chinese Medicines (TCMs), current advances in chemistry and fundamental processes of developmental biology and health are a research focus for Crews. According to him, a roadblock in the path to TCMs as a source for new medical treatments is lack of understanding the biology and chemistry of how they work.
Triptolide is a potent, biologically active compound isolated from the medicinal ‘Thunder God Vine’ Tripterygium wilfordii Hook F. The TCM tea Lei Gong Teng made from this plant has been used for centuries, as a therapeutic against cancer, inflammation, and auto-immune diseases. Crews and colleagues showed that triptolide causes cell growth arrest in certain cell types.
Normal kidney tubule cells have a built in switch for regulating their growth — two proteins, PKD1 and PKD2, located on a bristle-like cilium that bends in response to fluid flow across the cell. During kidney development, cells destined to line a kidney tubule grow and divide until the tubule is formed, as sensed by fluid flow in the tubule. Fluid flow bends the primary cilium, giving a signal to stop cell growth. PKD is caused by a mutation in the PPage: 1 2 Related medicine news :1
. Potential New Cancer Gene Identified2
. Lack of Smell And Its Potential Risks 3
. New Blood Thinner Pill - First Potential Alternative to Warfarin in 50 years4
. The Potential Of Cadaver Transplantation Programme In India5
. Another Potential Of Stem Cells Discovered: Used For Growing Cartilage6
. Yoga Guru Ramdev Invited to Tap Ayurveda Potential by Jharkhand Govt 7
. A Protein In Yoghurt Has The Potential To Fight E. coli8
. Gold Therapy- A Potential Treatment For Autoimmune Diseases9
. Whirlpool Bath Tubs Contain Potentially Lethal Bacterial Strains10
. Potential Benefits Of New Nanotechnology11
. Hormone Can Foretell Presence Of Potentially Fatal Pulmonary Hypertension