Navigation Links
Treatment of Sickle Cell Anemia Using Gene Therapy.

A research was conducted by Selda Samakoglu and colleagues at the Memorial Sloan-Kettering Cancer Center. This research opened new doors in the treatment of the genetic disease, Sickle cell anemia // . The treatment combines both gene therapy and RNA interference therapy. So far the treatment has worked well in the laboratory stage and will be of great success in curing the disorder.

Sickle cell disease is a genetic disease affecting 80,000 people in the US alone. The Red Blood Cells (RBCs) become lose there normal disk shape and become sickle shaped. Due to this abnormality there is hindrance in the movement of these sickled RBC. The movement inside the small blood vessels is restricted and this results in piling, clumping inside the vessels. This eventually blocks the vessels leading to stroke, pain, infection and organ damage.

This disease is very much prevalent among the Africans, Mediterranean, Indian or Middle Eastern individuals. At present the treatment is that the affected people are given a stem cell transplant from a donor. It is very difficult to find an exact mach and less than 20% of the children suffering from the diseases find a complete donor match.

The researchers said that at the moment they are working with animal model (mice) and after the tests results prove to be positive they will start human trails and bring about the treatment procedure in the main stream of medicine within a few years.

The stem cells taken from the bone marrow are cultured in the lab and a small RNA sequence that interferes with the production of beta S-globin is integrated. This is because this sequence that produces beta S-globin is altered in these patients hence the altered gene is prevented from getting translated to proteins. This set up is then inserted in a gene that promotes production of healthy hemoglobin chains.

The net result is the production of a transgene which is then inserted into a vector (virus) and i
'"/>




Page: 1 2

Related medicine news :

1. Advances in Treatment of Cataracts
2. Recommendations for Treatment of Blood Pressue
3. Treatment for Menieres disease
4. Treatment for pre-menstrual syndrome is ineffective
5. Better Treatment for obesity
6. Gene Treatment for Heart Disease
7. More People Seeking Treatment for Depression
8. Focused Treatment For Childhood Cancer
9. Inadequate Drug Treatment For Youth
10. FDA Approves New surgery Treatment for Farsightedness
11. Treatment of antibiotics ineffectual in bronchitis
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Treatment Sickle Cell Anemia Using Gene Therapy

(Date:3/27/2015)... PRUSSIA, PA and LONDON, UK (PRWEB) March 27, 2015 ... President of DrugDev SiteStart Melissa (Liss) Easy was named ... , The 40 Under 40 list spotlights 40 ... for their professional accomplishments and community involvement. Winners are ... in a special supplement of the Philadelphia Business Journal. ...
(Date:3/27/2015)... The report “CountryFocus: Healthcare, Regulatory and Reimbursement ... on and analysis of the healthcare, regulatory and reimbursement ... in 2013 amounted to 316.1 million, having grown at ... 2008. The country’s increasingly elderly population and corresponding increase ... boost the growth of the pharmaceutical market, which was ...
(Date:3/27/2015)... SMI (Silicon Microstructures, Inc.), a global MEMS pressure ... MEMS based ultra-miniature pressure sensor designed especially for the ... 220um x 75um provides ample space for 1-French catheter ... industry leading in vivo drift performance of 2 ... pressure range from 0 to 1,100 mmHg absolute. ...
(Date:3/27/2015)... 2015 When struck with the aftermath ... know where to begin. The latest eBook released ... attorney, offers accident victims a clear and concise process ... ensure their personal injury claim is seen through to ... first actions that should be taken immediately following the ...
(Date:3/27/2015)... To address their number one lawn care question which ... this video to explain the complicated dynamics between the light ... expected to thrive in, be it in dense building or ... Anytime a sun-loving plant is put in the shade the ... try to amend this issue by applying large quantities of ...
Breaking Medicine News(10 mins):Health News:DrugDev Founder Melissa Easy is 2015 Philadelphia Business Journal 40 Under 40 Honoree 2Health News:US Pharmaceutical Market worth $548.4 billion by 2020 Says a New Report Available at RnRMarketResearch.com 2Health News:US Pharmaceutical Market worth $548.4 billion by 2020 Says a New Report Available at RnRMarketResearch.com 3Health News:US Pharmaceutical Market worth $548.4 billion by 2020 Says a New Report Available at RnRMarketResearch.com 4Health News:SMI Launches Catheter Mountable Pressure Sensor 2Health News:Dax Jones Updated eBook on Trucking Accidents Offers Helpful Information to Crash Victims 2Health News:For Spring Turf Planting Season, Super-Sod Created a New How-To Video Entitled "Two Views on Shade and Turf" 2
... earlier Rhode Island Hospital study looking at data from ... per year were seen in emergency departments across the ... which examined emergency department visits from 2000 through 2005, ... the study period, an average of 88,563 each year. ...
... Shopping on the Internet may not be as environmentally friendly, ... and Traders are anything to go by. ... home deliveries has outweighed the reduction in carbon dioxide emissions ... said. ,The total CO2 emitted by cars fell ...
... the University of Southern California have identified a chemical ... brain to low blood sugar levels . ... to yield new insights in the fight against diabetes, ... the researchers, the chemical travels from the hindbrain, which ...
... in Massachusetts, resulting in calls mosquito spraying, though environmentalists ... a potentially deadly encephalitis. Though the incidence is rising, ... of objections from environmentalists. ,Nine regional control ... the time, the Norfolk County Mosquito Control Project, which ...
... found that grandchildren, who were taken care of by their ... of their grandparents as they age . ,The ... their grandparents and received their care and concern, were more ... ,"Even little things, like occasional babysitting for a ...
... made significant advances towards the development of a technique that ... variant CJD . ,The technique, which has so ... and accelerating the replication of prions - abnormal proteins that ... the disease. ,The method, known as known as ...
Cached Medicine News:Health News:Higher Rates of Trampoline Injuries 2Health News:Neurotransmitter That can Yield New Insights in the Fight Against Diabetes Identified 2Health News:Eastern Equine Encephalitis Spreading Its Tentacles in Massachusetts 2Health News:Eastern Equine Encephalitis Spreading Its Tentacles in Massachusetts 3Health News:Grandparents' Care Makes Grandchildren More Caring for Them 2Health News:Significant Advances in VCJD Prion Detection 2
(Date:3/27/2015)... March 27, 2015 Concord Medical Services ... CCM ), a leading specialty hospital management ... of radiotherapy and diagnostic imaging centers in ... of a purchase agreement under which Concord Medical ... of the Company, agreed to acquire the Fortis ...
(Date:3/26/2015)... 2015  The Burzynski Research Institute, Inc. (BRI) announced ... by the Department of Surgery at Kurume University ... have been published. The study, a randomized non-blinded ... as post-operative adjuvant therapy with and without Antineoplastons ... A total of 65 patients, ...
(Date:3/26/2015)... PASADENA, Calif. , March 26, 2015 ... San Gabriel Valley to perform transcatheter aortic valve replacement ... TAVR procedure is a revolutionary new way to replace ... use of a heart lung machine. The ... heart team led by Azhil ( Alex) Durairaj , ...
Breaking Medicine Technology:Concord Medical Announces Acquisition of Fortis Surgical Hospital in Singapore 2Concord Medical Announces Acquisition of Fortis Surgical Hospital in Singapore 3Huntington Memorial Hospital Performs Groundbreaking Minimally Invasive Replacement of Heart Valves 2
... Schein, Inc. (Nasdaq: HSIC ), the largest provider ... today that it will release its third quarter 2010 financial ... 2010, and will provide a live webcast of its earnings ... Eastern Daylight Time. Speakers on the call will include Stanley ...
... PITTSBURGH, Oct. 15 Mylan Inc. (Nasdaq: ... Inc. received final approvals from the U.S. Food and ... (ANDAs) for the generic versions of Hyzaar® Tablets, 50 ... 25 mg, 50 mg and 100 mg, both antihypertensives. ...
Cached Medicine Technology:Henry Schein to Webcast Third Quarter 2010 Conference Call Friday, October 29, at 10:00 a.m. EDT 2Mylan Receives Approvals for Generic Versions of Hyzaar® and Cozaar® 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: