Navigation Links
Treatment of Sickle Cell Anemia Using Gene Therapy.

A research was conducted by Selda Samakoglu and colleagues at the Memorial Sloan-Kettering Cancer Center. This research opened new doors in the treatment of the genetic disease, Sickle cell anemia // . The treatment combines both gene therapy and RNA interference therapy. So far the treatment has worked well in the laboratory stage and will be of great success in curing the disorder.

Sickle cell disease is a genetic disease affecting 80,000 people in the US alone. The Red Blood Cells (RBCs) become lose there normal disk shape and become sickle shaped. Due to this abnormality there is hindrance in the movement of these sickled RBC. The movement inside the small blood vessels is restricted and this results in piling, clumping inside the vessels. This eventually blocks the vessels leading to stroke, pain, infection and organ damage.

This disease is very much prevalent among the Africans, Mediterranean, Indian or Middle Eastern individuals. At present the treatment is that the affected people are given a stem cell transplant from a donor. It is very difficult to find an exact mach and less than 20% of the children suffering from the diseases find a complete donor match.

The researchers said that at the moment they are working with animal model (mice) and after the tests results prove to be positive they will start human trails and bring about the treatment procedure in the main stream of medicine within a few years.

The stem cells taken from the bone marrow are cultured in the lab and a small RNA sequence that interferes with the production of beta S-globin is integrated. This is because this sequence that produces beta S-globin is altered in these patients hence the altered gene is prevented from getting translated to proteins. This set up is then inserted in a gene that promotes production of healthy hemoglobin chains.

The net result is the production of a transgene which is then inserted into a vector (virus) and i s introduced into cell cultures. This virus is then taken into the stem cells of the sickle cell patients. After that the cells don’t produce beta S-globin but functions like the normal healthy Red Blood Cells. Further studies will be conducted even on the genetic disease Thalassemia which will be very useful in conducting human trials and studying the results of their sickle cell therapy.

The medical community appreciated the research and said the faster the cure more the lives will be saved. At present 1000 children are suffering from the disease and it would save their lives.

But they also warned that genetic therapy has its own disadvantages and complications similar to the various gene therapies. All of it has to be foreseen and eliminated for a safe procedure without any side effects to tackle sickle cell anemia.


'"/>




Related medicine news :

1. Advances in Treatment of Cataracts
2. Recommendations for Treatment of Blood Pressue
3. Treatment for Menieres disease
4. Treatment for pre-menstrual syndrome is ineffective
5. Better Treatment for obesity
6. Gene Treatment for Heart Disease
7. More People Seeking Treatment for Depression
8. Focused Treatment For Childhood Cancer
9. Inadequate Drug Treatment For Youth
10. FDA Approves New surgery Treatment for Farsightedness
11. Treatment of antibiotics ineffectual in bronchitis
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/23/2017)... ... February 23, 2017 , ... On February ... a letter to withdraw previous guidance issued by the Obama Administration ... guidance issued in May 2016 by the Obama Administration came in response to ...
(Date:2/23/2017)... CA (PRWEB) , ... February 23, 2017 , ... Los ... two episodes of WE TV’s “Mama June: From Not to Hot,” which will begin ... notable, “Mama” June Shannon, known to millions from the 2012 reality television series, “Here ...
(Date:2/23/2017)... ... February 23, 2017 , ... Dr. David Mahon leads Siena Dental, ... Dr. Mahon was named a 2017 Top Patient Rated Henderson Dentist by ... directory that recognizes local physicians and dentists who have earned high ratings and superior ...
(Date:2/23/2017)... ... February 23, 2017 , ... The Center for ... Island Consortium for Autism Research and Treatment (RI-CART) and Cinemaworld to present Sensory ... disorder (ASD) to see films in an environment that accommodates their unique needs. ...
(Date:2/23/2017)... ... 2017 , ... HealthPostures, the desk for standing designer headquartered in Prior Lake, ... the Minneapolis Home and Garden Show which is being held February 24 through 26 ... is the Minneapolis Convention Center. , From its broad line of sit stand ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... -- Nevro Corp. (NYSE: NVRO), a global medical device company ... chronic pain, today reported financial results for the three months ... 2016 Accomplishment & Highlights: Achieved revenue of ... 228% as reported, over the prior year U.S. ... over the prior year International revenue of ...
(Date:2/23/2017)... REDWOOD CITY, Calif. , Feb. 23, 2017 ... specialty pharmaceutical company focused on the development and ... moderate-to-severe acute pain, announced that it will release ... close on Thursday, March 2nd, 2017. AcelRx management ... p.m. Eastern Time (1:30 p.m. Pacific Time) on ...
(Date:2/23/2017)... , Feb 23, 2017 ... Research and Markets has announced the ... Industry Forecast to 2025" report to their offering. ... of around 1.8% over the next decade to reach approximately $12.8 billion ... estimates and forecasts for all the given segments on global as well ...
Breaking Medicine Technology: