Navigation Links
Treatment for cholesterol-related illnesses likely with the discovery of receptor in mice

Researchers have reported in the February issue of PNAS that understanding and treating cholesterol-related illnesses in humans may now be easier with the discovery of a receptor in the cells of mice that protects them from toxins. Researchers discovered the receptor during a study of cerebrotendinous xanthomatosis (CTX), a rare and often fatal disorder caused by excessive cholesterol metabolites. They said that Pregnane X receptor (PXR)// is present in humans but does not recognise or eliminate all toxins as effectively as it does in our diminutive counterparts. In mice, PXR senses the presence of excess cholesterol by-products and immediately activates special pathways that remove these toxins. The main problem with the PXR receptors in humans is that they are not activated by the metabolites to trigger an effective response and clear away the cholesterol.

The study suggested that harnessing PXR could benefit people with high cholesterol worldwide, apart from those patients suffering from CTX. They further added that CTX and other cholesterol-related illnesses could be treated or possibly even prevented with existing drugs like rifampicin and St. John's Wort, which do activate the PXR receptor in humans.


'"/>




Page: 1

Related medicine news :

1. Advances in Treatment of Cataracts
2. Recommendations for Treatment of Blood Pressue
3. Treatment for Menieres disease
4. Treatment for pre-menstrual syndrome is ineffective
5. Better Treatment for obesity
6. Gene Treatment for Heart Disease
7. More People Seeking Treatment for Depression
8. Focused Treatment For Childhood Cancer
9. Inadequate Drug Treatment For Youth
10. FDA Approves New surgery Treatment for Farsightedness
11. Treatment of antibiotics ineffectual in bronchitis
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/6/2016)... ... May 06, 2016 , ... Norwood Insurance Group, serving ... beneficiary of their ongoing community enrichment program. The current campaign is being extended ... faces many more months of treatments, leaving his family in great need of ...
(Date:5/6/2016)... ... May 06, 2016 , ... US Sports Camps has ... camp held at Oregon State University this summer. Employing world-class rugby figures, including former ... all skill levels with training on key fundamentals, match play, fitness and more. , ...
(Date:5/6/2016)... ... ... Logically, spring weather, with its moderate humidity and temperatures, should be ideal ... hot, water on the eye surface can evaporate, creating uncomfortable dry eye symptoms. In ... one problem, according to radio show and water advocate Sharon Kleyne: Spring is also ...
(Date:5/6/2016)... ... May 06, 2016 , ... The International Yoga Teacher Training schoo ... of the island close to the town famous for its sunsets, Oia. This all ... “We continue to have an amazing experience in Greece, we just can’t stay away” ...
(Date:5/6/2016)... ... 2016 , ... In honor of Military Spouse Appreciation Day ... the National Military Family Association, a nonprofit that works to strengthen and protect ... recipient of 2016. , “Being awarded this scholarship by Career Step, is ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... , May 5, 2016 ... addition of the  "Europe Systemic Lupus Erythematosus ...  report to their offering.       ... The latest research Europe Systemic Lupus Erythematosus ... provides comprehensive insights into Systemic Lupus Erythematosus ...
(Date:5/4/2016)... COUNTY, Calif. , May 4, 2016  It,s time for an upgrade. There ... shown on a brilliant 3.5 inch LCD, the illustrious DVMAXX HD  offers unparalleled ... brands as well as a world class manufacturer of innovative technology.  Photo ... ... ...
(Date:5/4/2016)... , May 4, 2016 ... Jerusalem announced today that it had signed an ... Inc. , developer of novel protein degradation and immunomodulatory ... and commercialization of drug candidates representing first-in-class therapy for ... were not disclosed. The novel technology was ...
Breaking Medicine Technology: