Navigation Links
Treatment Extends Survival in Mouse Model of Spinal Muscular Atrophy

Drug therapy can extend survival and improve movement in a mouse model of spinal muscular atrophy (SMA), new research shows. The study, carried out at the NIH’s National// Institute of Neurological Disorders and Stroke (NINDS), suggests that similar drugs might one day be useful for treating human SMA.

"This study shows that treatment can be effective when started after the disease appears," says Kenneth H. Fischbeck, M.D., of the NINDS, who helped lead the new study. The finding is important because most children with SMA are diagnosed after symptoms of the disease become obvious, he adds.

SMA is the most common severe hereditary neurological disease of childhood, affecting one in every 8,000-10,000 children. Babies with the most common form of the disease, called SMA type I, develop symptoms before birth or in the first few months of life and have severe muscle weakness that makes it difficult for them to breathe, eat, and move. They usually die by age two. Other forms of SMA are not as severe, but still cause significant disability. While some symptoms of SMA can be alleviated, there is currently no treatment that can change the course of the disease.

SMA is caused by mutations in a gene called SMN1. Investigators studying the genetics of SMA have found that there is another gene, called SMN2, on the same chromosome. While the normal form of SMN1 produces a full-length functional protein, most of the protein produced by SMN2 is truncated and unable to function. The relatively small amount of normal SMN protein produced by the SMN2 gene can reduce the severity of the disease. Therefore, investigators are searching for drugs that can increase the amount of normal protein produced by this gene.

The new study, directed by Dr. Fischbeck's colleague Charlotte J. Sumner, M.D., at NINDS, tested a drug called trichostatin A (TSA) that is in a class of drugs called histone deacetylase (HDAC) inhibitors. These drugs increase the a
'"/>




Page: 1 2 3

Related medicine news :

1. Advances in Treatment of Cataracts
2. Recommendations for Treatment of Blood Pressue
3. Treatment for Menieres disease
4. Treatment for pre-menstrual syndrome is ineffective
5. Better Treatment for obesity
6. Gene Treatment for Heart Disease
7. More People Seeking Treatment for Depression
8. Focused Treatment For Childhood Cancer
9. Inadequate Drug Treatment For Youth
10. FDA Approves New surgery Treatment for Farsightedness
11. Treatment of antibiotics ineffectual in bronchitis
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Treatment Extends Survival Mouse Model Spinal Muscular Atrophy

(Date:8/31/2015)... ... 01, 2015 , ... The PT Outcomes Registry is an organized system for ... patients. The Registry is being developed by the American Physical Therapy Association (APTA). , ... be selected to contribute FOTO Outcomes measures as one of the primary global outcomes ...
(Date:8/31/2015)... ... August 31, 2015 , ... ITC Global Translations website, ... for specific translation services within the medical and pharmaceutical industries. These are industries ... successful work. , ITC Global Translations specializes in professional translation services for materials ...
(Date:8/31/2015)... (PRWEB) , ... August 31, 2015 , ... ... insurance, announced today their new “ InstantQuote ” tool, which summarizes all available ... easy-to-understand format. The technology tool is designed to help India Network members make ...
(Date:8/31/2015)... Clarkston, Metamora, Michigan (PRWEB) , ... August 31, ... ... has launched pre and postnatal fitness classes. , Starting September 1st ... classes are called "The Mom Bod" and "Healthy Body, Healthy Baby." , More ...
(Date:8/31/2015)... , ... August 31, 2015 , ... The Sundance Film ... on Tuesday, September 1. , “Alive Inside” shadows a social worker who advocates for ... , “It’s a documentary about bringing music to residents in health care centers who ...
Breaking Medicine News(10 mins):Health News:FOTO Selected as Official Registry Partner with Physical Therapy Outcomes Registry 2Health News:GoMarketing Announces Major Updates to ITC Global Translations Website http://www.ITCGlobalTranslations.com 2Health News:GoMarketing Announces Major Updates to ITC Global Translations Website http://www.ITCGlobalTranslations.com 3Health News:India Network proudly launches the new InstantQuote tool to help choose right visitor health insurance with pre-existing conditions to US bound visitors 2Health News:Public Invited to Dementia Documentary Screening at North Carolina Retirement Community 2
... Streamlines Health Records Documentation , ... ... , a leading developer of healthcare software solutions for physician ... leader in enterprise content management and business process automation, to ...
... ALLEGAN, Mich., March 24 Perrigo Company (Nasdaq: ... received final approval from the U.S. Food and Drug ... The product has been determined to be therapeutically equivalent ... is indicated for the topical treatment of acne. Klaron(R) ...
... patients are thought to develop these infections, , , TUESDAY, ... in an antibacterial agent to the dressing around the ... reduce the chances that a potentially deadly infection will ... units (ICUs) usually require insertion of a central venous ...
... Using ANCC Certification Tests for Master,s Degree Competency ... Governors University (WGU), www.wgu.edu , and ... , have agreed to work together on a ... ANCC,s Nurse Executive Certification examination as the exit ...
... pleased to announce the formal partnership of the University ... 10x10 program. Bonnie Westra, PhD, RN, Assistant Professor and Co-Director ... will serve as the Director of the University of ... of Minnesota has adapted its tried and true graduate ...
... fatty acids appear protective against advanced prostate cancer, and ... in the COX-2 gene, according to a report in ... American Association for Cancer Research. , "Previous research has ... of the first studies to show protection against advanced ...
Cached Medicine News:Health News:iMedica and Imagetek Team up to Ease Transition to Paperless Medical Practice 2Health News:iMedica and Imagetek Team up to Ease Transition to Paperless Medical Practice 3Health News:iMedica and Imagetek Team up to Ease Transition to Paperless Medical Practice 4Health News:Perrigo Announces FDA Approval for Sulfacetamide Sodium Topical Suspension USP, 10% (Lotion) 2Health News:Drug-Coated Sponges May Limit Catheter Infections 2Health News:ANCC and WGU to Partner on Use of Nurse Credentialing Exams 2Health News:ANCC and WGU to Partner on Use of Nurse Credentialing Exams 3Health News:New AMIA 10x10 Program Partner -- University of Minnesota School of Nursing 2
(Date:8/31/2015)... PARK, Calif. , Aug. 31, 2015 /PRNewswire/ ... company focused on the emerging field of regenerative ... successfully dosed at Chicago -based ... clinical trial evaluating activity of escalating doses of ... with sensory and motor complete cervical spinal cord ...
(Date:8/31/2015)... Vascular Ltd., together with its subsidiaries (the "Company" ... the "Group"), a global company engaged in the ... for the minimally invasive treatment of vascular disease, ... ("BTK") cohort of patients in the Chocolate® Balloon ... 15, 2015 at the 5th Annual Amputation Prevention ...
(Date:8/31/2015)... , Aug. 31, 2015 Research ... addition of the "Prescription Pain Drugs - ... Marijuana - Global Markets, Competitors and Opportunities: 2015 ... their offering. Pain is defined ... with actual or potential tissue damage. At some ...
Breaking Medicine Technology:Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 4Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 5Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 6Final Results From Below-The-Knee Cohort In Chocolate Registry Presented At The 5th Annual Amputation Prevention Conference 2Final Results From Below-The-Knee Cohort In Chocolate Registry Presented At The 5th Annual Amputation Prevention Conference 3Final Results From Below-The-Knee Cohort In Chocolate Registry Presented At The 5th Annual Amputation Prevention Conference 4Prescription Pain Drugs Including Opioid, Anticonvulsant, Injectable/ Inhaled, Topical/ Transdermal, Medical Marijuana - 2015-2020 Analysis and Forecasts 2Prescription Pain Drugs Including Opioid, Anticonvulsant, Injectable/ Inhaled, Topical/ Transdermal, Medical Marijuana - 2015-2020 Analysis and Forecasts 3
... HARBIN, China , May 18 /PRNewswire-Asia-FirstCall/ -- ... (Nasdaq: CSKI ), a leading fully,integrated pharmaceutical company producing ... today announced record financial results,for the first quarter of 2010. ... Form 10-K for 2009. , , First ...
... HARBIN, China , May 18 ... Board: WKBT) ("Weikang" or the,"Company"), a leading developer, manufacturer ... and other health,and nutritional products in the People,s ... the first quarter of fiscal year 2010 ended on ...
Cached Medicine Technology:China Sky One Medical Announces First Quarter 2010 Results 2China Sky One Medical Announces First Quarter 2010 Results 3China Sky One Medical Announces First Quarter 2010 Results 4China Sky One Medical Announces First Quarter 2010 Results 5China Sky One Medical Announces First Quarter 2010 Results 6China Sky One Medical Announces First Quarter 2010 Results 7China Sky One Medical Announces First Quarter 2010 Results 8China Sky One Medical Announces First Quarter 2010 Results 9China Sky One Medical Announces First Quarter 2010 Results 10China Sky One Medical Announces First Quarter 2010 Results 11China Sky One Medical Announces First Quarter 2010 Results 12China Sky One Medical Announces First Quarter 2010 Results 13China Sky One Medical Announces First Quarter 2010 Results 14Weikang Bio-Technology Reports First Quarter 2010 Financial Results 2Weikang Bio-Technology Reports First Quarter 2010 Financial Results 3Weikang Bio-Technology Reports First Quarter 2010 Financial Results 4Weikang Bio-Technology Reports First Quarter 2010 Financial Results 5Weikang Bio-Technology Reports First Quarter 2010 Financial Results 6Weikang Bio-Technology Reports First Quarter 2010 Financial Results 7Weikang Bio-Technology Reports First Quarter 2010 Financial Results 8Weikang Bio-Technology Reports First Quarter 2010 Financial Results 9Weikang Bio-Technology Reports First Quarter 2010 Financial Results 10Weikang Bio-Technology Reports First Quarter 2010 Financial Results 11
... monitor elevates bedside glucose testing to a ... the quality of central laboratory testing. ... strip technology. Current glucose strips use ... system measures and corrects hematocrit interference as ...
The Tag-It™ Cystic Fibrosis ASR reagents can be used by high complexity CLIA approved laboratories for detection of up to 70 mutations and 6 variants (polymorphisms) in the cystic fibrosis tran...
... BreatheX is a wearable CPAP (Continuous Positive ... sleep apnea. The lightweight BreatheX CPAP device ... with its built-in, rechargeable battery, and is ... no longer need to be "plugged in ...
Paraffin Block Storage System...
Medicine Products: