Navigation Links
Transport of Proteins Unravels the Mystery behind Neurodegenerative Diseases

Neurodegenerative diseases are diseases which occur due to progressive degeneration of the nerves across the body. Some of the important and fatal diseases are Huntington's, ALS and Kennedy disease. // Researchers have found that the main causes for such diseases are the blockage of the transport of proteins within cells. Hence they feel that once the mechanism underlying the cell transport is unraveled then these diseases could be easily treated. In a new study published online June 4 in Nature Neuroscience, researchers from the University of Illinois at Chicago College of Medicine showed how a chemical pathway that is obstructed in Kennedy disease interferes with a cellular distribution system called ‘fast axonal transport’ that moves proteins from where they are synthesized to where they are needed in the cell. This transport system is critical in neurons because these cells can be as much as three feet long, says Dr. Scott Brady, professor and head of anatomy and cell biology at UIC.

‘A breakdown in fast axonal transport would selectively kill neurons because neurons are especially dependent on the transport system,’ Brady said. Kennedy disease is also known as spinal and bulbar muscular atrophy, or SBMA. Like the better-known ALS and Huntington's, it is a rare but devastating disease, affecting one in 40,000 people, usually between the ages of 30 and 50. Huntington's strikes about four times as many. Neurodegenerative diseases like SBMA are caused by the lengthening of part of a gene that encodes repetitions of the amino acid glutamine in the protein. Although different genes are affected, all of the polyglutamine-expansion or "polyQ" diseases are characterized by symptoms that begin in middle age and by the loss of certain types of neurons through a pattern in which the neuron's terminals die before the cell body.

PolyQ genes are expressed in many types of cells, but only neurons are affected. Earlier studies had linked specific neurodege nerative diseases to mutations in proteins involved in intracellular transport. This led researchers to wonder if the deranged polyQ proteins inhibit fast axonal transport in several diseases, including SBMA, in which a mutation in the receptor for testosterone leads to the loss of motor neurons. In the new study, Brady and his co-workers were able to show that polyQ-AR, the mutated protein in SBMA, caused inhibition of fast axon transport by activating an enzyme called JNK that can inhibit these transport proteins. Brady said this is the first proposed mechanism for polyQ diseases that explains why only nerve cells die and why the terminals die before the cell body. The link to the activation of the JNK enzyme suggests a new therapeutic target that might limit, delay or perhaps prevent progressive neurodegeneration, the researchers conclude.

'"/>




Related medicine news :

1. Ban On Transporting Poultry Lifted Off In Madhya Pradesh
2. Transporter offers reliable clues for safer pain medicine
3. Public Transport Causing Backaches in Delhi, Mumbai
4. Levels Of Blood Proteins May Help Heart Disease Care
5. Cholesterol can be lowered using combination of Soy Proteins and Sterols
6. Neurological Disorders Overcome By Proteins
7. Cancer Causing Proteins Trigger Abnormal Biochemical Reactions In Cells
8. NR2B Proteins Lead To Chronic Pain
9. Methyl-DNA binding Proteins To Fight Cancer
10. Ape Humans? Alterations in Proteins Affects Genes.
11. Researchers Discover Two Proteins Involved In Cellular Destruction Of HIV Virus
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... ... March 24, 2017 , ... Gastro Health ... to prep patients for colonoscopy at the HyGIeaCare® Center that is to be ... FL. , The HyGIeaCare® Prep, cleared by the U.S. Food and ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... with God #TruthwithGrace”: a devotional journal chronicling the writer’s path toward true communion ... to Walk with God #TruthwithGrace” is the creation of published author Lea Michelle ...
(Date:3/24/2017)... ... March 24, 2017 , ... “The Communion of Saints: A ... God in congregations across the United States. “The Communion of Saints” is ... who has served congregations in seven states throughout his long career of devotion ...
(Date:3/23/2017)... ... , ... A recent report from the National Council on Teacher Quality (NCTQ) ... suggests, based on a review of GPA and SAT/ACT requirements at 221 institutions in ... It argues that this higher bar should be set by states, by the Council ...
(Date:3/23/2017)... TX (PRWEB) , ... March 23, 2017 , ... ... clinic, located at 960 Gruene Road in Building 2. The clinic is the group’s ... Andrew Bennett, PT, says opening the company’s second New Braunfels location brings things full ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... Mar. 24, 2017 Research and Markets has announced ... Growth and Demand Forecast to 2022" report to their offering. ... The global wound care market ... at a CAGR of 6.7% during 2016-2022 Among the various ... largest share in the global market in 2015. Among the various applications, ...
(Date:3/24/2017)... -- FinancialBuzz.com News Commentary  ... According to new data published ... the legal cannabis market is projected to continue to grow ... from the current presidential administration. The report created by Arcview,s ... of growth in this industry are the passage and subsequent ...
(Date:3/24/2017)... -- Global Ampoules Market report provides a ... and industry chain structure. The Ampoules market analysis is ... landscape analysis, and major regions, development status. ... Complete ... 10 company profiles and 183 tables and figures is ...
Breaking Medicine Technology: