Navigation Links
Transplanted Pancreatic Tissue Could Help Diabetics

Millions of diabetics battle their illness with daily doses of insulin injections. However in people suffering with juvenile diabetes, transplants of the pancreatic tissue// could help solve the problem. Diabetes brings with it complications like blindness, amputation, kidney failure, and heart disease.

Unfortunately, there are not nearly enough organ donors available for transplantation. Insulin-producing pancreas tissues from animals could potentially provide a nearly unlimited supply for transplantation. But until now, attempts to transplant such animal tissues into non-human primates have evoked a fierce immune response. However, embryonic tissues, such as those from pigs (in which the insulin-producing cells are similar to those of humans), might not be rejected as strongly. New research by Prof. Yair Reisner of the Weizmann Institute's Immunology Department has brought the possibility of transplants from pig embryos one step closer. The results of the study appeared in the June issue of PLoS Medicine.

In previous work, Reisner and his team had shown that each embryonic organ has its own 'time window' during which the chances for successful transplantation are optimal. Prior to this window, the early tissue's cells, which are still largely undifferentiated, can give rise to tumors. Past the window, however, they may be too well-developed: The host identifies these cells as foreign, causing the body to reject them. By transplanting tissues from pig embryos into mice lacking proper immune systems, they determined that the best time frame for pancreatic tissue was about a third of the way through gestation (from 42 to 56 days).

In the new study, Reisner's team wanted to see if such tissues could function in the body. They first implanted embryonic pancreatic tissue from pigs into mice that lacked an immune system of their own, but had human immune cells injected into them. From this experiment they learned that tissues taken at 42 days (within the time frame they had previously determined) exhibited a markedly reduced immune response. Next, the team tried the experiment on mice with fully functioning immune systems, but destroyed the insulin-producing cells in their pancreases before proceeding with the transplant. With the aid of relatively mild immune suppression protocols, the implanted tissues were fully functional over time, producing insulin and maintaining the mice's blood sugar at normal levels.

"The results of this study," says Reisner, "warrant further, pre-clinical research on primate models."

Contact: Jennifer Manning

jennifer@acwis.org

212-895-7952

American Committee for the Weizmann Institute of Science

Source: Eurekalert
'"/>




Related medicine news :

1. Transplanted heart made more acceptable by daclizumab
2. Kidneys Can Be Transplanted From Animals Such As Pigs In Future
3. MRI Can Monitor Transplanted Islets
4. White Blood Cells Can Both Hurt and Help Transplanted Kidneys
5. Study Reveals Effects of WBCs on Transplanted Kidney
6. HIV Positive Organs Transplanted
7. New Drug Mix to Extend Life of Transplanted Kidneys
8. Transplanted Pig Cells in Human Produce Insulin
9. Gene Therapy Destroys Pancreatic Cancer Cells
10. Ulcer Surgery connected to danger of Pancreatic Cancer
11. Pancreatic Cancer may be linked to Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/21/2017)... ... July 21, 2017 , ... The Karen Miller Agency, a ... in the greater Birmingham area, is joining the Chris Hammond Youth Foundation in ... the region. , The Chris Hammond Youth Foundation maintains athletic facilities in rural ...
(Date:7/21/2017)... ... July 21, 2017 , ... Thomas Jefferson University ... , was awarded a $300,000 grant from The Pew Center for Arts & ... ambiguity and the recognition of one’s own limits among health professions students. ...
(Date:7/21/2017)... ... 21, 2017 , ... The Margarian Law Firm has filed a class ... ale for allegedly containing no ginger. Dr. Pepper produces the “Canada Dry” brand of ... Margaryan alleges Canada Dry Ginger Ale claims on its bottle that it is made ...
(Date:7/21/2017)... ... July 21, 2017 , ... MedMatchPlus+ has ... chances of acceptance to a residency in a United States hospital. Being accepted ... the U.S. , According to data released by the ECFMG®, every year, 50 ...
(Date:7/21/2017)... ... July 21, 2017 , ... West Dermatology is pleased to announce the ... July 17, 2017, Ms. Vu will join West Dermatology’s large network of medical and ... skin cancer , and more. She graduated from the University of Florida College ...
Breaking Medicine News(10 mins):
(Date:7/19/2017)... 19, 2017  Mako Medical Laboratories partnered with Secretary ... Family Assistance Fund (MFA) to bring 140 soldiers back ... with their families one last time before being deployed. ... travel and logistics needed for these soldiers. "Mako Medical ... their families. We just wish we could bring them ...
(Date:7/14/2017)... 13, 2017 It should come as no surprise ... is in the midst of a crippling opioid epidemic. According ... the number of overdose deaths from opiate-based medications has quadrupled, ... a million dead from 2001 to 2015". During this time, ... has similarly quadrupled, drawing a compelling link between prescription and ...
(Date:7/12/2017)... , July 12, 2017 CarpalAID is a revolutionary ... braces or surgery. Carpal tunnel syndrome affects more than ... at twice the rate of men. The common methods of treating ... mobilization with uncomfortable hand braces or gloves. ... CarpalAID is a clear patch ...
Breaking Medicine Technology: