Navigation Links
Translating Structure into Function

Scientists have perfected ways to determine the knot-like structure of enzymes, but theyve been stumped trying to translate the structure into an understanding of function what the enzyme actually does in the body.

This puzzle has hindered drug discovery, since many of the most successful drugs work by blocking enzyme action. Now, in an expedited article in NATURE, researchers show that a solution to the puzzle is finally in sight.

A team co-led by UCSFs Brian Shoichet, Steven Almo of the Albert Einstein College of Medicine, and Frank Raushel of Texas A&M describes the first success decrypting an enzymes function from its structure. If their new strategy works with other enzymes, it should become a potent tool to determine how key enzymes work in the body.

And since enzyme action is crucial to disease, the technique opens an efficient route to drug discovery, Shoichet say. Schoichet a professor of pharmaceutical chemistry and an investigator in the California Institute for Quantitative Biomedical Research, or QB3, based at UCSF.

The teams success came by modifying a technique called molecular docking, a computer-aided modeling strategy used to search for potential drugs. Docking works by allowing researchers to first determine the atom-by-atom structure of an enzyme and then screen many thousands of molecules for one that fits into the empty active site of the enzyme.

Shoichet calls this a search for the missing piece of a jigsaw puzzle. A molecule that fits the enzymes active site will block its activity just what many promising drugs do.

The strategy works well for one kind of drug discovery -- finding molecules to fit in the active site and physically block enzyme action. But the research team sought to divine from an enzymes structure just what natural molecule triggers the enzyme into action -- fitting into the active site and enabling the enzyme to act as a catalyst.

This wa
'"/>




Page: 1 2

Related medicine news :

1. Relationship Between Genetic Structure And Quality of Life
2. Abnormal Brain Structure One Of The Reasons For Depression in Adolescents
3. Structure of the brain to increase risk for anxiety disorders
4. Changes In Brain Structure From Methamphetamine Abuse And HIV Infection
5. Almond Structure in the Brain Intrigues Researchers
6. Controversy over Fees Structure in Private Medical Colleges
7. Controversy Over The Fee Structure In Private Medical Colleges Surfaces Yet Again
8. Education Structure In Indian Schools To Be Revamped Soon
9. Neither Management Nor Students Happy With New Fee Structure
10. DNA-bound p53 Tumor Suppressor Protein Structure Determined
11. Structure of DNA-modifying enzyme In Small Pox Determined
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Translating Structure into Function

(Date:11/26/2014)... November 26, 2014 Increasing demand ... include image guided surgeries has paved way for ... Rising incidence of various types of cancers and ... increase in demand for these owing to their ... contrast media injectors market can also be attributed ...
(Date:11/26/2014)... German scientists say carbon-based synthetic molecules ... mesothelioma that looks and acts similar to asbestos-induced mesothelioma. ... the research. Click here to read it now. ... and Experimental Medicine in Hannover injected 500 lab rats ... rats eventually developed mesothelioma , how quickly it ...
(Date:11/26/2014)... For its December issue , ... Report on Blue Cross and Blue Shield Plans* interviewed ... varied strategies the two Blues plans are implementing in ... for sleep apnea, ranging from brick-and-mortar retail stores to ... to increased rates of a variety of serious disorders, ...
(Date:11/26/2014)... (PRWEB) November 26, 2014 With Thousand ... of dollars, the prosthodontists at the Anacapa Dental Art Institute ... dental procedures can be daunting for some. , That is ... the procedures they offer. , “No dentist wants cost to ... set of teeth,” said Dr. Mamaly Reshad, partner in the ...
(Date:11/26/2014)... the video interviewing specialist, has today announced the appointment ... Officer, in addition to the formal opening of it’s ... appointed as Chief Operating Officer. He is joined by ... Officer. , Mr Jones is a seasoned tech, media ... with The Walt Disney Company and Adventis where he ...
Breaking Medicine News(10 mins):Health News:Contrast Media Injectors Market To 2020 - Global Industry, Growth, Size, Share, Trends, Analysis And Forecast To 2020 Research Report By Grand View Research, Inc. 2Health News:Contrast Media Injectors Market To 2020 - Global Industry, Growth, Size, Share, Trends, Analysis And Forecast To 2020 Research Report By Grand View Research, Inc. 3Health News:Multi-walled Nanotubes Linked to Mesothelioma in New Study, According to Surviving Mesothelioma 2Health News:AIS Newsletter Reports on Strategies Blues Plans Are Implementing to Combat Sleep Apnea 2Health News:AIS Newsletter Reports on Strategies Blues Plans Are Implementing to Combat Sleep Apnea 3Health News:Anacapa Dental Art Institute Doctors Offers 6 Tips on How to Pay for Cosmetic, Restorative and Implant Dentistry 2Health News:Anacapa Dental Art Institute Doctors Offers 6 Tips on How to Pay for Cosmetic, Restorative and Implant Dentistry 3Health News:Anacapa Dental Art Institute Doctors Offers 6 Tips on How to Pay for Cosmetic, Restorative and Implant Dentistry 4Health News:Anacapa Dental Art Institute Doctors Offers 6 Tips on How to Pay for Cosmetic, Restorative and Implant Dentistry 5Health News:Sonru Expansion continues with appointment of new executive team and opening of new London base 2
... uncovers "biologic treatments", ROSEMONT, Ill., Nov. 3 ... proteins repair fractured bones published in the,November 2008 ... of Orthopaedic,Surgeons ( http://www.jaaos.org/ ) demonstrates that understanding ... improved and less invasive,treatments for fractures., "The ...
... Nov. 3 World Champion athlete and health,and ... as a member of the,California Governor,s Council on ... to the student body of NEW Academy Canoga ... healthy lifestyles., (Photo: http://www.newscom.com/cgi-bin/prnh/20081103/AQM074 ), ...
... Pa., Nov. 3 BMP Sunstone,Corporation (Nasdaq: BJGP ... plans to release third quarter 2008 financial results on,Monday, ... Company will hold a conference call at 9:00 am ... third quarter 2008 results.,Listeners may access the call by ...
... Provider Services Cited as Pivotal to ... Billing Efficiency Statewide, NASHVILLE, Tenn., Nov. 3 ... solutions for the healthcare industry,has been named the electronic ... Hospital Association (MHA). Emdeon was selected,through a competitive bidding ...
... $50 million in annual revenue for SXC,s ... 3 /PRNewswire-FirstCall/ - SXC Health Solutions Corp.,("SXC" or ... announces that its,pharmacy benefit management (PBM) division, informedRx, ... of San Mateo (HPSM) valued at more,than $50 ...
... seatbelts more common for adolescents illegally at the wheel, study ... if the thought of teenagers driving before they,ve gotten their ... kids are also more likely to drive while drinking or ... they get behind the wheel. , Reporting in the November ...
Cached Medicine News:Health News:The Biology of Broken Bones Leads to New Treatments 2Health News:The Biology of Broken Bones Leads to New Treatments 3Health News:Laila Ali Debuts as Member of California Governor's Council on Physical Fitness and Sports 2Health News:BMP Sunstone to Report Third Quarter 2008 Financial Results 2Health News:Emdeon Selected by the Maryland Hospital Association to Power the Maryland Transaction Data Interchange 2Health News:SXC Health Solutions announces PBM services agreement with Health Plan of San Mateo 2Health News:Many Unlicensed Teen Drivers Put Safety Last 2Health News:Many Unlicensed Teen Drivers Put Safety Last 3
(Date:11/24/2014)... Nov. 24, 2014 Luoxis Diagnostics, Inc., ... AMPE), today announced the presentation of three clinical ... as a broadly applicable and robust research tool ... body in response to injury, illness, or stress.  ... collaboration with Luoxis, academic and pharmaceutical research partners, ...
(Date:11/24/2014)... -- Relmada Therapeutics, Inc. (OTCQB: RLMD), a clinical-stage company developing ... today that Sergio Traversa , chief executive officer, ... Event" Micro-Cap Growth Conference on Wednesday, December 3, 2014.  ... Bel Air Hotel, which is located at 11461 Sunset ... The presentation is scheduled for 8:30 a.m. ...
(Date:11/24/2014)... , Nov. 24, 2014  AiCure, an artificial ... technology to monitor medication ingestion, has announced the ... and intervene with patients receiving medication as maintenance ... overdoses from prescription opiates have quadrupled in the ... per year than heroin, cocaine and benzodiazepines combined. ...
Breaking Medicine Technology:Luoxis Announces Presentation of Multiple Studies Validating RedoxSYS as a Rapid and Non-invasive Means of Assessing Oxidative Stress 2Luoxis Announces Presentation of Multiple Studies Validating RedoxSYS as a Rapid and Non-invasive Means of Assessing Oxidative Stress 3Luoxis Announces Presentation of Multiple Studies Validating RedoxSYS as a Rapid and Non-invasive Means of Assessing Oxidative Stress 4Luoxis Announces Presentation of Multiple Studies Validating RedoxSYS as a Rapid and Non-invasive Means of Assessing Oxidative Stress 5Relmada Therapeutics To Present At LD MICRO Conference 2Can artificial intelligence solve the $55 billion problem of opioid abuse? 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: