Navigation Links
Transdermal Vaccine Effective in Treating Alzheimer's Disease in Mice

University of South Florida researchers report that a novel needle-free vaccine approach// is effective and safe in clearing brain-damaging plaques from a mouse model of Alzheimer’s disease.

The transdermal, or across the skin, vaccination, may offer a simpler way of preventing or treating the devastating neurodegenerative disease with less likelihood of adverse immune reactions.

The study was published online this week in The Proceedings of the National Academy of Sciences.

“While many groups have shown vaccinating against the beta amyloid protein (Ab) can reduce Alzheimer’s-like pathology including certain cognitive deficits, this study is the first to demonstrate that immunization using the skin may be an effective way to reduce Ab pathology,” said senior study author Jun Tan, PhD, MD, director of the Neuroimmunology Laboratory at the Institute for Research in Psychiatry, USF Department of Psychiatry.

“The beauty is that something as simple and non-invasive as a skin patch could potentially be a promising therapy for Alzheimer’s disease,” said study coauthor Terrence Town, PhD.

The Alzheimer’s vaccine works by triggering the immune system to recognize Ab -- a protein that abnormally builds up in the brains of Alzheimer’s patients – as a foreign invader and attack it.

Previous research on an injectable Alzheimer’s vaccine proven safe and effective in an animal model was suspended indefinitely when the initial clinical trial caused brain inflammation and death in a small percentage of patients. These serious side effects were secondary to an autoimmune reaction, which occurred when immune cells aggressively attacked the body’s own proteins produced by the vaccine.

The USF researchers targeted the skin as the route of vaccine delivery in mice bred to develop age-related brain degeneration mimicking Alzheimer’s. They found that transdermal immunization with Ab does not appear to trigger specific toxicities associated with past immunization strategies.

Specialized immune cells prevalent in the skin, called Langerhans, may direct the body’s reaction to the vaccine toward a response that is beneficial instead of overly aggressive and ultimately harmful, Dr. Tan said.

The USF researchers plan to further test whether the transdermal vaccine can curb memory loss in Alzheimer’s mice as well as reduce their “senile” plaque burden. “If those studies show clear cognitive benefits,” Dr. Tan said, “we believe clinical trials to evaluate a beta amyloid skin patch or topical cream in patients with Alzheimer’s would be warranted.”

Surce-Newswise
SRM
'"/>




Related medicine news :

1. Transdermal HRT not cardioprotective in postmenopausal women with CAD
2. Transdermal HRT not cardioprotective in postmenopausal women with Coronary Artery Disease
3. Vaccine to quit smoking?
4. First Vaccine Designed for Africa Cleared for Testing in Humans
5. Vaccine for Alzheimer’s diseas
6. Health Officials Recommend Flu Vaccine
7. Smallpox Vaccine May Help Fight Cervical Cancer
8. Panacea Biotech To Market Anthrax Vaccine
9. New Prostate Cancer Vaccine Shows Promise
10. Drug Firm Offers to Donate Smallpox Vaccine
11. Vaccine guards against shingles
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
(Date:6/24/2016)... ... 2016 , ... Those who have experienced traumatic events may suffer from a ... such as drug or alcohol abuse, as a coping mechanism. To avoid this pain ... following a traumatic event. , Trauma sufferers tend to feel a range of emotions, ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension ... that it will receive two significant new grants to support its work to ... its 25th anniversary by recognizing patients, medical professionals and scientists for their work ...
(Date:6/24/2016)... ... , ... Comfort Keepers® of San Diego, CA is excited to announce they ... to drive cancer patients to and from their cancer treatments. Comfort Keepers provides ... life and ongoing independence. Getting to and from medical treatments is one of ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Clinical Decision Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The ... published in Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 Research ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural Health ... Structural electronics involves electronic and/or electrical ... structures, replacing dumb structures such as vehicle bodies ...
(Date:6/24/2016)... 2016 Dehaier Medical Systems Ltd. (NASDAQ: ... markets and sells medical devices and wearable sleep respiratory ... strategic cooperation agreement with Hongyuan Supply Chain Management Co., ... June 20, 2016, to develop Dehaier,s new Internet medical ... Dehaier will leverage Hongyuan Supply Chain,s sales platform to ...
(Date:6/24/2016)... , June 24, 2016 Research and ... Market for Companion Diagnostic Tests" report to their offering. ... for Companion Diagnostics The World Market for ... personalized medicine diagnostics. Market analysis in the report includes the ... Market (In Vitro Diagnostic Kits) by Region (N. America, EU, ...
Breaking Medicine Technology: