Navigation Links
Toxic Strand Of RNA Causes Myotonic Muscular dystrophy

me 19, which is now part of a genetic, diagnostic test for myotonic dystrophy.

In their latest research, Mahadevan and colleagues created a new type of mouse model with many extra copies of the CTG repeats, each attached to DNA for a protein that glows green under a microscope. They also integrated an "on switch" for MMD in the mice, activated by giving them doxycycline, an antibiotic, in their drinking water.

When mice began to produce many copies of RNA with CTG repeats, they developed the hallmarks of type 1 MMD within a few weeks, including an inability to relax muscles and heart rhythm abnormalities. When doxycycline was stopped, mice stopped producing toxic RNA and returned to normal, except in cases when the heart was severely damaged.

So far, however, Mahadevan and other scientists can't explain exactly what happens inside the cell to cause someone to get myotonic dystrophy. "The prevailing theory is that the RNA remains in the nucleus, rather than moving out of it, and proteins get stuck to the RNA and aren't able to do their job," Mahadevan said.

This toxic RNA in not found in every cell of body, Mahadevan said. Rather, it is produced in higher levels in muscle cells, in the heart and brain, in the lining of the intestines and in the lens and muscles of the eyes.

(Source: EurekAlert)
'"/>




Page: 1 2

Related medicine news :

1. Toxic effects common with AIDS treatments
2. Toxic chemicals found in domestic products poisoning newborn babies
3. Bifidogenic Growth Stimulator: A Non-Toxic Way To Treat Ulcerative Colitis
4. Acute Toxicity Of Nano-Scale Zinc Powder: Severe Renal Damage And Anemia
5. Passive smoking declared as Toxic in California
6. Bacteria Can Convert Flame Retardant Into Toxic Form
7. "Miracle" Cancer Drug Gleevec Can be Toxic to the Heart
8. Agricultural Workers Taken ill after Inhaling Toxic Fumes in Orissa
9. Toxic and Addictive Foods Responsible For Obesity
10. Herceptin Use May Enhance Cardiac Toxicity, Study
11. Scientists Develop Non-Toxic, Food Safe Paint
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Toxic Strand RNA Causes Myotonic Muscular dystrophy

(Date:8/23/2014)... (PRWEB) August 23, 2014 Youth substance ... Texas. It’s no different in Houston, TX. Substance abuse ... falling victim to drug and alcohol dependency in higher ... looking to beat substance abuse, but don’t know where ... treatment facility can be a challenge because most treatment ...
(Date:8/23/2014)... 23, 2014 Teen substance abuse ranks as ... Holly Springs, NC. Countless adolescents throughout North Carolina struggle with ... Unfortunately, many never receive professional rehab due to a lack ... to get help. Troubled Teens Holly Springs is a helpline ... local teenage alcohol abusers in Wake County who ...
(Date:8/22/2014)... August 23, 2014 Search Engine ... the first page of search engines and get ... Hosting has recently compared many Linux hosting suppliers ... Bluehost are the most recommended Linux hosting suppliers ... and Europe to buy high quality Linux hosting ...
(Date:8/22/2014)... 2014 Deep Research Report on ... in-depth research report on the Glucose Meter market. ... Glucose Meter definition, classification, application, and industry chain ... covers the international market analysis, including domestic market ... environment & economic situation analysis. The report on ...
(Date:8/22/2014)... Recently, Skmen.com, an experienced supplier of ... bohemian dresses in its online store. Moreover, all these ... to 28% off. All the international clients can obtain ... 2014. , The company’s professional online workers update ... worldwide customers more the latest information about its new ...
Breaking Medicine News(10 mins):Health News:New Houston Hotline Assisting Juveniles in Locating Dependable Rehabilitation Help 2Health News:New Helpline Provides Teen Drug & Alcohol Recovery Information in Holly Springs, NC 2Health News:Top10BestSEOHosting.com Announces Best Cheap Hosting Suppliers Of This Summer 2Health News:Glucose Meter Industry Global (Europe, Asia, NA, ROW) Analysis Now Available at ReportsnReports.com 2Health News:Glucose Meter Industry Global (Europe, Asia, NA, ROW) Analysis Now Available at ReportsnReports.com 3Health News:Cheap Bohemian Dresses Unveiled by Experienced Supplier Skmen.com 2
... ACNE TREATMENT EMBRACES DIFFERENCES IN MEN,S,AND WOMEN,S SKIN BY ... TREATMENT SOLUTION, SUMMIT, N.J., Oct. 30 Here,s ... between men and women are no more than skin,deep. ... care product, each,gender will be able to address these ...
... DENVER, Oct. 30 Air Methods Corporation,(Nasdaq: AIRM ) announces the ... Webcast, When: November 6, 2008 @ 4:15 ... Live over the Internet -- Simply log ... address above., Contact: Christine Clarke ...
... common gene variations may be responsible for much of ... New research on the MYH9 geneand its implications for ... the African American populationwill be summarized in a press ... Nephrology,s 41st Annual Meeting and Scientific Exposition in Philadelphia, ...
... Many with Eating Disorders, PHOENIX, Oct. 30 ... disorders are worried about treatment and not,seeking the help ... help for an eating disorder can be very,serious because ... Wall, PhD, director of psychological services at Remuda Ranch,Programs ...
... - Expands Therapy to Broader Patient Population -, ... Inc.,(NYSE: HSP ), a global specialty pharmaceutical ... Food and Drug Administration (FDA),approved a new indication ... This approval allows for use of Precedex in,non-intubated ...
... on a wide range of patient treatment experiences ... and features of ... Altrazeal(TM) -, LAS VEGAS, Oct. 30 ULURU ... application of Altrazeal(TM) -,Transforming Powder Dressing were presented yesterday at a special session,of ...
Cached Medicine News:Health News:Finally ... A Chance for Both Men and Women to Take CTRL(TM) of Their Own Skin! 2Health News:Finally ... A Chance for Both Men and Women to Take CTRL(TM) of Their Own Skin! 3Health News:MYH9 gene variations help explain high rate of kidney disease in African-Americans 2Health News:MYH9 gene variations help explain high rate of kidney disease in African-Americans 3Health News:MYH9 gene variations help explain high rate of kidney disease in African-Americans 4Health News:Remuda Ranch Reports Many Individuals With Eating Disorders Are Not Getting Help They Need 2Health News:FDA Approves New Indication for Hospira's Precedex (Dexmedetomidine HCL) Injection 2Health News:FDA Approves New Indication for Hospira's Precedex (Dexmedetomidine HCL) Injection 3Health News:FDA Approves New Indication for Hospira's Precedex (Dexmedetomidine HCL) Injection 4Health News:ULURU Inc. Hosts Symposium on Altrazeal(TM) at the 23rd Annual Clinical Symposium on Advances in Skin & Wound Care 2Health News:ULURU Inc. Hosts Symposium on Altrazeal(TM) at the 23rd Annual Clinical Symposium on Advances in Skin & Wound Care 3
(Date:8/22/2014)... On Aug. 20, at its annual meeting in ... voted on and approved a delegate resolution opposing the ... Cannabis Corp., a leading Canadian licensed producer of medicinal ... The CMA is quite right to point out that ... material, including medicinal cannabis. While some patients, particularly those ...
(Date:8/22/2014)... Equity Research highlights Epizyme (Nasdaq: EPZM - Free Report ... PNRA - Free Report ) as the Bear of the Day. ... FOLD - Free Report ), Sanofi (NYSE: SNY - ... ). Here is a synopsis of all five stocks: ... The biotech bull market is far from over due to ...
(Date:8/22/2014)... , Aug. 22, 2014  Cannabis Science, Inc. ... formulation-based drug development and related consulting, is pleased ... international medical cannabis conference taking place at the ... , on October 22, 2014.  The multilingual ... such as researchers, health professionals, and patients, to ...
Breaking Medicine Technology:Bedrocan Canada Statement Regarding Canadian Medical Association Motion on Smoking Marijuana 2Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 2Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 3Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 4Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 5Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 6Cannabis Science, Inc. (CBIS) to Sponsor 3rd International Conference on Cannabinoids in Medicine in October 2014 in Strasbourg, France 2Cannabis Science, Inc. (CBIS) to Sponsor 3rd International Conference on Cannabinoids in Medicine in October 2014 in Strasbourg, France 3
... ARBOR, Mich., Nov. 9 Thomson Reuters ... a leading clinical surveillance solution that enables hospitals to ... improve clinical quality and reduce total cost of treatment. ... at no additional cost. , CareFocus 2.0 ...
... Nov. 9 Arcadia Resources, Inc. (NYSE Amex: ... care services under the Arcadia HealthCare(SM) brand, has appointed ... will replace Tres Lund who announced his resignation from ... http://www.newscom.com/cgi-bin/prnh/20091109/DE07521 ) , Goldsmith is the Daniel ...
Cached Medicine Technology:Thomson Reuters Clinical Surveillance Solution Offers Powerful New Functionality to Improve Clinical Quality and Reduce Costs 2Thomson Reuters Clinical Surveillance Solution Offers Powerful New Functionality to Improve Clinical Quality and Reduce Costs 3Arcadia Resources Names Stephen Goldsmith to Board of Directors 2Arcadia Resources Names Stephen Goldsmith to Board of Directors 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: